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Daxor Announces Publication of 3 Studies in Heart Failure Patients and Cardiac Bypass Patients with the BVA-100 Blood Volume Analyzer.


Business Editors

NEW YORK--(BUSINESS WIRE)--Feb. 6, 2003

Daxor Corporation (AMEX AMEX

See: American Stock Exchange
:DXR DXR Danbury Municipal Airport, Danbury CT (airport code)
DXR Data Extraction and Recording
DXR X-Director
DXR Dynamic Extended Resolution
), a leading medical instrumentation and biotechnology company, today announced that two new studies conducted at the Columbia Presbyterian Medical Center, #1 ranked hospital in the NY region, were published in the medical journal Circulation, (Circulation.2003;107:294-299). The first study, authored by Dr. Ana-Silvia Androne, Dr. Stuart Katz, et al, utilized the Daxor BVA-100 Blood Volume Analyzer to measure the degree of blood volume expansion in congestive heart failure congestive heart failure, inability of the heart to expel sufficient blood to keep pace with the metabolic demands of the body. In the healthy individual the heart can tolerate large increases of workload for a considerable length of time.  patients. They compared their findings to an independent physician's estimate of whether the patients had significant expanded blood volume or were normal. In half the heart failure patients, the physicians were not able to detect the abnormal expanded blood volume. The implications of these findings are that blood volume measurement can enable more precise treatment in patients. Congestive heart failure patients are treated with diuretics Diuretics Definition

Diuretics are medicines that help reduce the amount of water in the body.
Purpose

Diuretics are used to treat the buildup of excess fluid in the body that occurs with some medical conditions such as congestive heart
 to remove excessive blood volume. Over treatment with diuretics can be just as harmful as under treatment in improving patients' conditions.

The second study published in the same journal authored by Dr. Donna M. Mancini, Dr. Stuart Katz, et al, involves the treatment of heart failure patients who were found to be anemic by the standard hematocrit Hematocrit Definition

The hematocrit measures how much space in the blood is occupied by red blood cells. It is useful when evaluating a person for anemia.
Purpose

Blood is made up of red and white blood cells, and plasma.
 test. The standard hematocrit only measures the concentration of red blood cells Red blood cells
Cells that carry hemoglobin (the molecule that transports oxygen) and help remove wastes from tissues throughout the body.

Mentioned in: Bone Marrow Transplantation

red blood cells 
 in relation to plasma, but does not inform the treating physician of the actual volume of red blood within the patient's circulation. The authors found that treatment of these patients with Erythropoetin significantly improved the symptoms of these patients. Blood volume measurement with the BVA-100 also enabled identification of those patients who were hemodiluted and had increased plasma volume from those patients who were truly anemic and had low red cell volume. Erythropoetin, manufactured by Amgen and Johnson & Johnson, is a restricted drug which increases a patient's red cell volume. The measurement of blood volume has implications for the treatment of patients who may be inappropriately denied treatment because their blood volume is not measured.

A third study was published in the November 2002 issue of the Journal of Clinical Anesthesia by Ketan Shevde, MD, Murali Pagala, PhD, et al, from Maimonides Hospital, involving patients undergoing coronary bypass coronary bypass

Surgical treatment for coronary heart disease to relieve angina pectoris and prevent heart attacks. It became widely used in the 1960s. One or more blood vessels—usually an artery in the chest or a vein from the leg—are transplanted to create
 graft surgery. The patients had their blood volume measured with the BVA-100 prior to surgery. Women were found to be significantly more anemic than men and required more blood transfusions. The authors concluded that the increased number of transfusions required for women was related to their low red cell volume prior to surgery.

Dr. Joseph Feldschuh, President of Daxor, who is a cardiologist Cardiologist
Doctor who specializes in diagnosing and treating heart diseases.

Mentioned in: Electrophysiology Study of the Heart, Lithotripsy


cardiologist

a physician who specializes in the diagnosis and treatment of heart disease.
, stated that "At the present time it is very difficult for physicians to judge when they have over treated or under treated patients. Congestive heart failure is the #1 cause for admission of patients over the age of 65 into hospitals. More precise treatment has the potential for reducing the frequency and extent of hospitalization of congestive heart failure patients. The study at Maimonides suggests that where surgery is not immediately required, patients, particularly women, may benefit from blood volume measurement and aggressive treatment with Erythropoetin to increase their red cell volume prior to surgery."

Daxor Corporation manufactures and markets the BVA-100, a semi-automated Blood Volume Analyzer. The BVA-100 is used in conjunction with a single use diagnostic kit. It is the first instrument to provide rapid, direct measurement of a patient's blood volume with a high degree of precision. Among nationally renowned hospitals using the BVA-100 Blood Volume Analyzer are NYU NYU New York University
NYU New York Undercover (TV show) 
 Medical Center, The Mayo Clinic Mayo Clinic: see Mayo, Charles Horace.

Mayo Clinic

voluntary association of more than 500 physicians in Rochester, Minnesota. [Am. Hist.: EB, 11: 723]

See : Medicine
 and The Cleveland Clinic Cleveland Clinic (formally known as the Cleveland Clinic Foundation) is a multispecialty academic medical center located in Cleveland, Ohio, USA. Cleveland Clinic was established in 1921 by four physicians for the purpose of providing patient care, research, and medical , as well as other major medical institutions. More information about the BVA-100 and other Daxor products and services can be found at www.daxor.com.
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Date:Feb 6, 2003
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