Dad's hidden influence: a father's legacy to a child's health may start before conception and last generations.Pregnant women know the drill. Don't drink. Don't smoke. Don't eat too much fish. Take vitamins. Mothers have long shouldered the responsibility, and the blame, for their children's health Children's Health Definition
Children's health encompasses the physical, mental, emotional, and social well-being of children from infancy through adolescence. . Fathers don't usually face the same scrutiny.
How a man lives, where he works, or how old he is when his children are conceived doesn't affect their long-term health, scientists used to think. But growing evidence suggests that a father's age and his exposure to chemicals can leave a medical legacy that lasts generations.
Animal studies demonstrate that drugs, alcohol, radiation, pesticides, solvents, and other chemicals can lead to effects that are handed from father to son. Human studies are less clear, but some show that fathers play a role in fetal development and the health of their children.
Teenage dads face increased risk that their babies will be born prematurely, have low birth weight, or die at birth or shortly afterward, a new study in Human Reproduction shows.
Babies of firefighters, painters, woodworkers, janitors, and men exposed to solvents and other chemicals in the workplace are more likely to be miscarried, stillborn stillborn /still·born/ (-born) born dead.
Dead at birth.
n an infant who is born dead.
born dead. , or to develop cancer later in life, according to a review in the February Basic & Clinical Pharmacology & Toxicology.
Fathers who smoke or are exposed at work to chemicals called polycyclic aromatic hydrocarbons put their children at risk of developing brain tumors.
And, older fathers are more likely to have children with autism autism (ô`tĭzəm), developmental disability resulting from a neurological disorder that affects the normal functioning of the brain. It is characterized by the abnormal development of communication skills, social skills, and reasoning. , schizophrenia, and Down syndrome Down syndrome, congenital disorder characterized by mild to severe mental retardation, slow physical development, and characteristic physical features. Down syndrome affects about 1 in every 730 live births and occurs in all populations equally. and to have daughters who go on to develop breast cancer.
Though some of these observations are decades old, attitudes lag even further behind, says Cynthia Daniels, a political scientist at Rutgers University-New Brunswick in New Jersey. Dads aren't held accountable if something goes wrong during fetal development.
MATTER OF MATH Since men make new sperm every 74 days, people used to reason, the genetic slate is wiped clean every couple of months. And even if a man makes defective sperm, the "all-or-nothing" view of reproduction holds that damaged sperm don't fertilize eggs. No harm. No foul.
So no one bothers to remind men to protect themselves against environmental toxins. There are no images of "crack dads" and "crack babies" in the media like those of women who harm developing fetuses with drug and alcohol use, Daniels said in February at a meeting of the American Association for the Advancement of Science American Association for the Advancement of Science (AAAS), private organization devoted to furthering the work of scientists and improving the effectiveness of science in the promotion of human welfare. held in Boston.
When someone does study fathers-to-be, the focus is usually on fertility, not on the consequences for children's health, she says.
Yet even fertility messages meet resistance from many men.
Harry Fisch, director of the Male Reproductive Center and a urologist Urologist
A physician who deals with the study and treatment of disorders of the urinary tract in women and the urogenital system in men.
Mentioned in: Congenital Bladder Anomalies, Lithotripsy, Men's Health, Overactive Bladder
urologist at Columbia University Medical Center Columbia University Medical Center is the name of the medical complex associated with Columbia University, and covers several blocks (primarily between 165th and 168th Streets from the Henry Hudson Parkway to Audubon Avenue) in the Washington Heights section of Manhattan. , found that out when he suggested that men, like women, have ticking biological clocks.
Men can produce sperm throughout life, but that doesn't mean their cells are forever young.
"Every cell in the body ages," says Fisch. "Every cell. The older you get, the more chance of an abnormality. The same thing goes for sperm."
Men younger than 20 and older than 30 make more abnormal sperm than men in their 20s. These damaged sperm could create an unhealthy embryo or pass on damage that could lead to birth defects birth defects, abnormalities in physical or mental structure or function that are present at birth. They range from minor to seriously deforming or life-threatening. A major defect of some type occurs in approximately 3% of all births. or illness in offspring.
It is not a popular message.
"Men do not want to hear this," Fisch says. "When my book came out, I got e-mails. I got faxes saying, 'How dare you say this? How can you say this? We know that there are men in their 70s having healthy children.'"
Despite these anecdotal accounts of elderly dads, studies demonstrate that older men are at increased risk of passing on genetic abnormalities. It's a matter of math.
Women are born with all the eggs they will produce in their lifetime. The cells that give rise to eggs divide 24 times, all before birth. But the cells that produce sperm continue to divide throughout a man's lifetime. Each year after puberty, a man's sperm-producing cells replicate about 23 times. Every time the cells divide is another chance for error.
As a result, the sperm produced by a 40-year-old man have gone through about 610 rounds of replication. That's 610 chances of introducing a mutation in the DNA DNA: see nucleic acid.
or deoxyribonucleic acid
One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. , or improperly divvying up genetic material.
Parents over age 40 are six times more likely to have children with Down syndrome than 25-year-old parents, Fisch and colleagues showed in a 2003 study in the Journal of Urology urology
Medical specialty dealing with the urinary system and male reproductive organs. It traces its origin to medieval lithologists, itinerant healers who specialized in surgical removal of bladder stones. . An extra copy of chromosome 21 causes Down syndrome. This extra chromosome is just as likely to come from dad as room in the older couples.
Older dads also have a higher risk of fathering children with rare mutations that cause dwarfism dwarfism, condition in which an animal or plant is less than normal in size and lacks the capacity for normal growth. Dwarfism is deliberately produced and perpetuated in certain species (e.g., in breeding miniature dogs and cultivating dwarf plants). or a premature aging disease called Hutchinson-Gilford progeria progeria
Disorder with characteristics of premature aging. Affected persons have thin skin, go bald or gray early, and develop diseases of aging decades earlier than normal individuals. syndrome.
But sometimes aging fathers pass along traits that can't be traced to only a single mutation. Fathers 40 and older have an increased chance that their children will develop complex disorders such as autism or schizophrenia. There is growing evidence that those disorders are caused by defects in many genes and the way genes are turned off and on.
Scientists don't yet understand the changes that age induces in sperm-making germ cells, and environmental exposure presents an even bigger mystery. People come in contact with a plethora of chemicals every day. But it is no easy task to sort out exactly which ones, or which combinations, cause heritable her·i·ta·ble
1. Capable of being passed from one generation to the next; hereditary.
2. Capable of inheriting or taking by inheritance. problems. The effects chemicals and radiation may have on offspring don't always follow predictable patterns either.
And when researchers do find a clear link between a father's lifestyle and his children's health, it's not always clear what the data mean.
"What we can say is that we identified a group of fathers with adverse outcomes for their fetuses, but we don't have an idea of the mechanism," says Shi Wu Wen of the University of Ottawa
Wen and his colleagues examined birth records for more than 2.6 million babies born between 1995 and 2000 to married, first-time, 20-something mothers in the United States. Looking at the husbands' ages, the team found that babies of teenage fathers, but not middle-age men, had an elevated risk of still birth, low birth weight, and other birth problems. The study was published online Feb. 6 in Human Reproduction.
'PREPOSTEROUS' INHERITANCE Some animal studies showing paternal effects emerged years ago but were roundly dismissed, says Gladys Friedler, professor emeritus at Boston University.
Four decades ago, Friedler was studying tolerance to narcotics, one of the first steps of addiction. To find out if a mother rat could pass tolerance on to her offspring along with antibodies and other immune factors, as some scientists theorized, Friedler exposed female rats to morphine before pregnancy, Babies of exposed mothers were born much smaller than average. And those babies also went on to give birth to tiny babies, even though the offspring had never encountered the drug.
Friedler also gave male rats morphine before they bred. "To my total disbelief and bewilderment, paternal exposure also affected progeny," Friedler said at the AAAS AAAS American Association for the Advancement of Science. meeting.
Her adviser dismissed the result. Morphine doesn't cause mutations, so the idea that males could hand down a trait without passing along a mutation seemed preposterous. The whole thing smacked of Lamarckism, the long-rejected idea that environmental influences can change an animal or plant's structure and offspring can inherit that change.
But in recent decades, scientists have discovered that chemical modifications to DNA and proteins can change the way genes are packaged and regulated without changing the genes themselves. Such modifications are known as epigenetic epigenetic /epi·ge·net·ic/ (-je-net´ik)
1. pertaining to epigenesis.
2. altering the activity of genes without changing their structure. changes.
"What was Lamarckian is now epigenetic," Friedler says.
Epigenetic modifications act as a molecular scrapbook, preserving memories of events in parents' lives and handing them down to the next generation and beyond.
"There's a chromosomal memory," says Anne Ferguson-Smith, a developmental geneticist ge·net·i·cist
A specialist in genetics.
a specialist in genetics.
geneticist at Cambridge University in England. "The chromosomes remember whether they came from the mother or the father."
That memory is established in the form of a chemical mark called methylation methylation,
n a phase-II detoxification pathway in the liver; methyl groups combine with toxins to rid the body of various substances.
(meth´ . Methylation usually turns a gene off. At least 100 genes in humans are turned off only on the chromosome contributed by the mother or only on the chromosome that came from the father. Such genes are called imprinted genes because of the indelible impression parents leave on their offspring's DNA.
Several imprinted genes help build the placenta placenta (pləsĕn`tə) or afterbirth, organ that develops in the uterus during pregnancy. It is a unique characteristic of the higher (or placental) mammals. In humans it is a thick mass, about 7 in. or encode growth factors that need to be tightly controlled so an embryo will develop correctly. "There's a contribution from both parents that is essential," Ferguson-Smith says. "One can't do without the other. They must work together to have a healthy offspring."
Imprints and other methylation marks are not encoded in the DNA. Instead the epigenetic modifications decorate chromosomes like ornaments on a Christmas tree Christmas tree
Evergreen tree, usually decorated with lights and ornaments, to celebrate the Christmas season. The use of evergreen trees, wreaths, and garlands as symbols of eternal life was common among the ancient Egyptians, Chinese, and Hebrews. . But these ornaments are heirlooms of a different type. It's as if a seedling grows straight from the ground already gussied gus·sy
tr.v. gus·sied, gus·sy·ing, gus·sies Slang
To dress or decorate elaborately; adorn or embellish: gussied herself up in sequins and feathers. up with tinsel tin·sel
1. Very thin sheets, strips, or threads of a glittering material used as a decoration.
2. Something sparkling or showy but basically valueless: the tinsel of parties and promotional events. and lights in the same places its parents were decorated. If a chemical or aging alters the epigenetic pattern on a man's chromosomes, his heirs could bequeath To dispose of Personal Property owned by a decedent at the time of death as a gift under the provisions of the decedent's will.
The term bequeath applies only to personal property. mismarked DNA to their children, too. Some mistakes may be as benign as exchanging a red bulb for a blue one. Other alterations, akin to placing the star on the lowest branch instead of the treetop, are likely to have more profound consequences.
Male mice exposed to cocaine, for example, pass memory problems on to their pups, a 2006 study in Neurotoxicology and Teratology teratology /ter·a·tol·o·gy/ (ter?ah-tol´ah-je) that division of embryology and pathology dealing with abnormal development and the production of congenital anomalies.teratolog´ic
n. shows. The male mice inhaled cocaine in long daily sessions akin to crack binges. When they mated with females never given coke, they had pups that had trouble learning and remembering where to find food in simple mazes. The problem was especially severe for female offspring. The researchers couldn't find any obvious DNA damage in coke-smoking males' sperm, but did find altered levels of two enzymes involved in the methylation of DNA in sperm-producing tissue in the father mice. The result suggests that epigenetic changes may be responsible for the offspring's behavior problems.
FUNGICIDE fungicide (fŭn`jəsīd', fŭng`gə–), any substance used to destroy fungi. Some fungi are extremely damaging to crops (see diseases of plants), and others cause diseases in humans and other animals (see fungal infection). LEGACY Matthew Anway doesn't know whether the rats in his lab at the University of Idaho The university was formed by the territorial legislature of Idaho on January 30, 1889, and opened its doors on October 3, 1892 with an initial class of 40 students. The first graduating class in 1896 contained two men and two women. in Moscow have methylation problems. Some studies suggest they do, but Anway doesn't yet have definitive proof.
He can prove that male rats exposed to a fungicide in the womb can pass tumors and diseases of the prostate and kidney down for at least three generations. The rats could provide the first model for how prostate disease is inherited, he says.
Male babies born to mothers that had been injected with fungicide had prostate problems that mimic those seen during human aging. The second-generation rats also had more tumors, kidney defects, and higher rates of abscesses, cysts, and other infections than unexposed control rats. Germ cells in the testes testes
Male reproductive organs (see reproductive system). Humans have two oval-shaped testes 1.5–2 in. (4–5 cm) long that produce sperm and androgens (mainly testosterone), contained in a sac (scrotum) behind the penis. of exposed rats also died more quickly than those in the control rats.
Subsequent generations of male rats also had the prostate and testes defects, and both male and female offspring developed kidney problems and tumors.
But only male rats could pass along the defects. The exposed rats bequeathed their fungicide legacy to their sons, grandsons, and great-grandsons even though none of the later generations were exposed to the chemical.
Exposed animals decrease production of enzymes that methylate methylate /meth·yl·ate/ (meth´i-lat)
1. a compound of methyl alcohol and a base.
2. to add a methyl group to a substance.
1. DNA, Anway says. But he hasn't yet found consistent changes in the methylation patterns in exposed rats.
It's not clear whether Anway's results have any implication for human health. The rats were exposed to extremely high doses of fungicide through the completely unnatural route of injection.
What's important is that the male shares experiences with descendants for years to come. Further research could give new insights, Anway says, into how alterations in early development could lead to adult disease in humans.