DHEA reverses increases bone mass in women.
Comment: DHEA is an androgen produced in women primarily by the adrenal glands and to a lesser extent by the ovaries. It is metabolized in part to estrogen and testosterone. In addition, DHEA appears to have physiological actions that are unrelated to its function as a precursor hormone, including stimulation of osteoblasts. The results of the present study indicate that DHEA can increase bone mass in elderly women, although it was not effective in men.
Weiss EP et al. Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone. Am J Clin Nutr. 2009;89:1459-1467.
by Alan R. Gaby, MD
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|Title Annotation:||Literature Review & Commentary|
|Author:||Gaby, Alan R.|
|Article Type:||Brief article|
|Date:||Nov 1, 2009|
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