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CytoGenix Announces Results of synDNA(TM) Smallpox Vaccine Study.


HOUSTON -- CytoGenix, Inc. (OTCBB OTCBB

See OTC Bulletin Board (OTCBB).
:CYGX) announced positive results of an animal study designed and conducted by the laboratory of Dr. David Weiner at the University of Pennsylvania (body, education) University of Pennsylvania - The home of ENIAC and Machiavelli.

http://upenn.edu/.

Address: Philadelphia, PA, USA.
 Medical School Philadelphia. These tests demonstrated that a CytoGenix technique for generating synthetic DNA DNA: see nucleic acid.
DNA
 or deoxyribonucleic acid

One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes.
 vaccines called synDNA(TM) as an smallpox vaccine smallpox vaccine
n.
A vaccine containing vaccinia virus suspensions that is inoculated subcutaneously to immunize against smallpox.
, was highly potent in generating an immune response immune response
n.
An integrated bodily response to an antigen, especially one mediated by lymphocytes and involving recognition of antigens by specific antibodies or previously sensitized lymphocytes.
.

DNA vaccines are comprised of genes that confer immunologic protection by producing antigens without the need to expose the body to pathogenic organisms. For this study, CytoGenix scientists prepared a synDNA(TM) vaccine containing a gene sequence provided by Dr. Weiner that produces a protein that is an essential component of the smallpox virus smallpox virus
n.
See variola virus.
.

Scientists in Dr. Weiner's laboratory tested and compared levels of antibodies and killer T cells produced in mice by the synDNA(TM) smallpox vaccine to a traditional plasmid DNA vaccine. The synDNA(TM) vaccine generated immunoglobulin and T cell levels in test animals several times greater than a comparable plasmid DNA vaccine produced by bacterial fermentation.

Dr. David B. Weiner, Associate Professor, University of Pennsylvania Medical School, Department of Pathology and Laboratory Medicine, a leading expert in DNA vaccines, commented, "We are impressed with the results from this study, the data, while preliminary are exciting."

Frank Vazquez, CytoGenix, Inc.'s Executive Vice President and COO, commented, "These results confirm the effectiveness of synDNA(TM) vaccines in producing substantial immunologic activity. The positive results we have achieved with our DNA vaccine tests are an excellent foundation for developing vaccines against biodefense related targets and for Avian Influenza avian influenza: see influenza.  H5N1."

About CytoGenix: CytoGenix, Inc. is a Houston-based biopharmaceutical company that develops and markets innovative products and services based on its proprietary ssDNA expression technology. The company has developed a breakthrough synthetic process for large-scale production of high purity DNA at a fraction of the cost of traditional fermentation methods. CytoGenix currently has one issued US patent and 41 international or US pending patent applications claiming methods and materials in connection with this platform technology.

SAFE HARBOR Safe Harbor

1. A legal provision to reduce or eliminate liability as long as good faith is demonstrated.

2. A form of shark repellent implemented by a target company acquiring a business that is so poorly regulated that the target itself is less attractive.
: Except for statements of historical fact, the statements in this press release are forward-looking. Such statements are subject to a number of risks and uncertainties that could cause actual results to differ materially from the statements made. These factors include, but are not limited to, general economic conditions, risks associated with the acceptance of new products, competition, and other factors more fully detailed in the company's filings with the Securities and Exchange Commission.

Additional information about CytoGenix and its technology can be found on the website at www.cytogenix.com.
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Copyright 2006, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Geographic Code:1USA
Date:Jan 4, 2006
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