CytRx Reports 2005 Fourth Quarter Financial Results.

LOS ANGELES -- CytRx Corporation (Nasdaq:CYTR), a biopharmaceutical company engaged in the development and commercialization of human therapeutics, today reported financial results for the fourth quarter and year ended December 31, 2005.

"I am delighted to report that our achievements during the past year have brought us closer to our goal of commercializing human therapeutics based on our small molecule 'molecular chaperone' co-induction technology," said CytRx President and CEO Steven A. Kriegsman. "Most notable among our achievements in 2005 was the advancement of our orally-available small molecule drug candidate arimoclomol into Phase II development for the treatment of amyotrophic lateral sclerosis, also know as ALS or Lou Gehrig's disease.

"We also made excellent progress in our HIV vaccine program. Interim results from a Phase I trial indicate our novel DNA + protein vaccine is the first to produce potent antibody responses with neutralizing activity against multiple HIV viral strains, and we expect to announce final results from this trial next quarter," Mr. Kriegsman added.

Review of Financial Results

For the fourth quarter of 2005, CytRx reported a net loss of $3.6 million, or $0.06 per share, compared with a net loss of $5.8 million, or $0.15 per share, for the fourth quarter of 2004.

Revenue for the fourth quarter of 2005 was $173,000, compared with $100,000 in the fourth quarter of 2004. Revenue in both periods included $100,000 of license fees paid with respect to CytRx's TranzFect vaccine adjuvant technology. Revenue in the fourth quarter of 2005 also included $73,000 of service revenue. All future licensing fees under current licensing agreements are dependent upon successful development milestones being achieved by the licensor.

Research and development (R&D) expenses were $2.3 million in the fourth quarter of 2005 versus $4.1 million in the comparable period in 2004. R&D expenses in the fourth quarter of 2004 included a $3 million expense of certain costs associated with the acquisition of compounds from Biorex Research and Development, RT. General and administrative expenses were $1.5 million for the 2005 fourth quarter, compared with $1.8 million for the 2004 fourth quarter.

The net loss for the year ended December 31, 2005, was $15.1 million, or $0.27 per share, compared with a net loss of $16.4 million, or $0.48 per share, for the year ended December 31, 2004. Revenue for the year ended December 31, 2005, was $184,000, compared with $428,000 for the year ended December 31, 2004. Revenue for 2005 included $100,000 of license fees paid with respect to CytRx's TranzFect technology and $83,000 of service revenue, while 2004 revenue consisted entirely of license fees. Total operating costs and expenses for the year ended December 31, 2005 were $15.7 million, versus $17.0 million in 2004.

As of December 31, 2005, cash and cash equivalents totaled $8.3 million, compared with $3.0 million as of December 31, 2004. The increase reflects completion of a private placement in January 2005 with net proceeds to the Company of $19.4 million. Working capital was $6.3 million as of December 31, 2005, compared with $1.2 million as of December 31, 2004. In March 2006, CytRx received approximately $12.4 million in net proceeds from the private sale of common stock and warrants.

2005 and Recent Highlights

Significant accomplishments made by CytRx during the past year include:

Arimoclomol for ALS Program

In September 2005, CytRx initiated a 10-center, 80-patient Phase IIa clinical trial with arimoclomol for ALS, a deadly neurodegenerative disorder with no effective treatment. CytRx expects to complete enrollment shortly. During 2005, the U.S. Food and Drug Administration (FDA) granted orphan drug status and fast track designation to arimoclomol for the treatment of ALS. CytRx expects to complete the Phase IIa trial in the third quarter of 2006 and then commence a Phase IIb efficacy trial for arimoclomol, subject to FDA review and approval. CytRx believes that successfully demonstrating safety and efficacy in this latter Phase II clinical trial could be sufficient to support product registration with the FDA.

In February 2006, CytRx initiated an open-label extension trial with arimoclomol for patients who have completed the Phase IIa clinical trial. Patients in the extension trial receive treatment with arimoclomol at the highest of the three Phase IIa dose levels for up to an additional six months. The open label extension trial is designed to provide additional safety and tolerability data in combination with the current Phase IIa trial.

HIV Vaccine Program

World health officials estimate 40 million people are now infected with HIV. Some 3 million people died of AIDS last year worldwide, and millions more are expected to die from AIDS this year. In March 2005, the enrollment of healthy volunteers in a three-arm Phase I clinical trial of DP6-001, a novel polyvalent HIV DNA + protein vaccine, was completed. The HIV vaccine formulation, which is exclusively licensed to CytRx, was created by researchers at the University of Massachusetts Medical School (UMMS) and Advanced BioScience Laboratories (ABL) and funded under a $16 million five-year HIV Vaccine Design and Development Team contract from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). Interim results of the trial indicated that the HIV vaccine was generally well-tolerated, stimulated immune "T-cells" that potentially can attack AIDS virus-infected cells and produced potent antibody responses with neutralizing activity against multiple HIV viral strains. Preliminary results suggested that even the lowest dosage of the DNA portion of the vaccine alone was sufficient to stimulate T-cell immune response. As HIV is a highly mutating viral disease, the ability of one vaccine to neutralize multiple strains simultaneously could be essential and has been considered among the primary challenges to development of a successful HIV vaccine. CytRx expects to announce final results from the Phase I trial of its HIV vaccine in the second quarter of 2006.

RNAi-based Drug Discovery Programs

CytRx is developing ribonucleic acid interference (RNAi) as a tool to identify drug targets as part of an expanded collaborative agreement with UMMS. Over the past year, research programs have discovered and validated approximately 30 new type 2 diabetes and obesity drug targets with the use of CytRx's high-throughput RNAi screening platform. Extension of the RNAi screening platform includes muscle and liver cells in addition to fat cells.

In August 2005, CytRx advanced RNAi against RIP 140, a nuclear hormone co-repressor that regulates fat accumulation, into development for the treatment of type 2 diabetes and obesity. In addition, the Company advanced two proprietary small molecule leads against novel upstream AMP-activated protein kinase targets into proof-of-concept animal experiments.

In early 2006, CytRx announced plans to transfer all of its RNAi therapeutics assets into a newly-formed subsidiary to accelerate the development and commercialization of RNAi drugs. Formation is expected to be completed in the coming months, subject to obtaining financing to fund the separate RNAi business. CytRx expects to retain significant ownership in the new entity.

Other corporate highlights include the following:

Scientific Advisory Board

In September 2005, Geoffrey Burnstock, Ph.D., DSc., F.A.A., FMedSci, FRS, one of the world's foremost neuroscientists, joined the CytRx Scientific Advisory Board. He was named by The Institute of Scientific Information in 2004 as the single most cited international scientist in pharmacology and toxicology during the prior decade. He has been awarded the prestigious Queen's Royal Gold Medal by the Royal Society and the titles of Honorary Fellow of the Royal College of Surgeons and Honorary Fellow of the Royal College of Physicians, which are among the United Kingdom's highest medical degrees. Professor Burnstock played a major role in the development of arimoclomol.

Research Publications

The January 2006 issue of peer-reviewed The Journal of Clinical Investigation included a significant CytRx-funded research article highlighting for the first time that RIP140 suppression by RNAi in cell culture enhances insulin responsiveness and oxidative metabolism. Michael P. Czech, Ph.D., professor and chair of molecular medicine at UMMS, was the principal author of the article entitled "Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional co-repressor RIP140 in mouse adipocytes." Dr. Czech serves as Chairman of the CytRx Metabolic Scientific Advisory Board.

About CytRx Corporation

CytRx Corporation is a biopharmaceutical research and development company engaged in the development of high value human therapeutics. The Company owns three clinical-stage compounds based on its small molecule "molecular chaperone" co-induction technology (CCI), as well as a targeted library of 500 small molecule CCI analogs. CytRx has initiated a Phase IIa clinical trial with its lead CCI small molecule product candidate arimoclomol for the treatment of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease). Arimoclomol has received orphan drug status and fast track designation from the U.S. Food and Drug Administration. CytRx has previously announced that a novel polyvalent HIV DNA + protein vaccine exclusively licensed to CytRx and developed by researchers at UMMS and Advanced BioScience Laboratories, and funded by the National Institutes of Health, demonstrated very promising interim Phase I clinical trial results that indicate its ability to produce potent antibody responses with neutralizing activity against multiple HIV viral strains. CytRx also has a broad-based strategic alliance with UMMS to develop novel compounds in the areas of ALS, obesity, type 2 diabetes and cytomegalovirus (CMV) using RNAi technology. The Company has a research program with Massachusetts General Hospital, Harvard University's teaching hospital, to use RNAi technology to develop a drug for the treatment of ALS. CytRx Drug Discovery division, located in Worcester, MA focuses on the use of RNAi technologies to develop small molecule and RNAi therapeutics to treat obesity and type 2 diabetes. For more information, visit CytRx's Web site at www.cytrx.com.

About the University of Massachusetts Medical School

The University of Massachusetts Medical School, one of the fastest growing academic health centers in the country, has built a reputation as a world-class research institution, consistently producing noteworthy advances in clinical and basic research. The Medical School attracts more than $174 million in research funding annually, 80% of which comes from federal funding sources. Research funding enables UMMS scientists to explore human disease from the molecular level to large-scale clinical trials. Basic and clinical research leads to new approaches for diagnosis, treatment and prevention of disease. Visit www.umassmed.edu for additional information.

About Advanced BioScience Laboratories

Advanced BioScience Laboratories, Inc. (ABL) located in Kensington, Md., is a biomedical research, development and manufacturing company focusing on human retroviral diseases. ABL has been a leader in HIV-1 research for more than two decades and has been involved in the development of methods to both prevent and treat HIV-1 infection.

Forward-Looking Statements

This press release may contain forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended. Examples of such statements include, but are not limited to, statements relating to the expected timing, scope and results of our clinical development and research programs, including the initiation of clinical trials, and statements regarding the potential benefits of our drug candidates and potential drug candidates. Such statements involve risks and uncertainties that could cause actual events or results to differ materially from the events or results described in the forward-looking statements, including risks or uncertainties regarding the scope of the clinical testing that may be required by regulatory authorities for our molecular chaperone co-induction drug candidates, including with respect to arimoclomol for the treatment of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), our HIV vaccine candidate and our other product candidates, and the outcomes of those tests; uncertainties related to the early stage of our diabetes, obesity, cytomegalovirus, or CMV, and ALS research; the need for future clinical testing of any small molecules and products based on ribonucleic acid interference, or RNAi, that may be developed by us; the significant time and expense that will be incurred in developing any of the potential commercial applications for our small molecules or RNAi technology; risks or uncertainties related to our ability to obtain capital to fund our ongoing working capital needs, including capital required to fund the RNAi development activities to be conducted by our planned new subsidiary; and risks relating to the enforceability of any patents covering our products and to the possible infringement of third party patents by those products.. Additional uncertainties and risks are described in CytRx's most recently filed SEC documents, such as its most recent annual report on Form 10-K, all quarterly reports on Form 10-Q and any current reports on Form 8-K filed since the date of the last Form 10-K. All forward-looking statements are based upon information available to CytRx on the date the statements are first published. CytRx undertakes no obligation to publicly update or revise any forward- looking statements, whether as a result of new information, future events or otherwise.

CYTRX CORPORATION
                 CONDENSED CONSOLIDATED BALANCE SHEETS
                               (Audited)


                                           December 31,   December 31,
                                               2005           2004
                                          ------------- --------------
ASSETS
Current assets:
        Cash and short-term investments     $8,299,390     $2,999,409
        Accounts Receivable                    172,860             --
        Prepaid and other current assets       315,606        956,146
                                          ------------- --------------
            Total current assets             8,787,856      3,955,555
Property and equipment, net                    352,641        447,579
Molecular library, net                         372,973        447,567
Goodwill                                       183,780             --
Prepaid insurance and other assets             241,660        198,055
                                          ------------- --------------
            Total assets                    $9,938,910     $5,048,756
                                          ============= ==============
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
        Accounts payable                      $815,626     $1,661,104
        Accrued expenses and other
         current
         liabilities                         1,639,922      1,074,146
                                          ------------- --------------
            Total current liabilities        2,455,548      2,735,250
Accrued loss on facility abandonment                --        206,833
Deferred gain on sale of building                   --         65,910
Deferred revenue                               275,000        275,000
                                          ------------- --------------
            Total liabilities                2,730,548      3,282,993
                                          ------------- --------------
Minority interest in subsidiary                     --        170,671
                                          ------------- --------------
Commitments and contingencies                       --             --
Stockholders' equity:
        Preferred stock, $.01 par value,
        5,000,000 shares authorized,
        including 5,000 shares of Series A
        Junior Participating Preferred
        Stock; no shares issued and
        outstanding                                 --             --
        Common stock, $.001 par
        value, 125,000,000 shares
        authorized; 59,284,000 and
        40,190,000 shares issued at
        December 31, 2005 and
        2004, respectively                      59,284         40,190
        Additional paid-in capital         130,715,363    110,028,327
        Treasury stock, at cost (634,000
        shares, at cost, held at December
        31, 2005 and 2004)                  (2,279,238)    (2,279,238)
        Accumulated deficit               (121,287,047)  (106,194,187)
                                          ------------- --------------
            Total stockholders' equity       7,208,362      1,595,092
                                          ------------- --------------
            Total liabilities and
             stockholders' equity           $9,938,910     $5,048,756
                                          ============= ==============



                           CYTRX CORPORATION
            CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                               (Audited)


                       Three Months Ended       Twelve Months Ended
                          December 31,               December 31,
                    --------------------------------------------------
                         2005        2004         2005         2004
                    --------------------------------------------------
Revenues:
  Service revenues      $72,860         $--      $82,860          $--
  License fees          100,000     100,000      101,500      428,164
                    --------------------------------------------------
                        172,860     100,000      184,360      428,164
                    --------------------------------------------------
Expenses:
 Research and
  development
  (includes $98,000
  and $220,000 of
  non-cash stock-
  based expense for
  the three and
  twelve-month
  periods ended
  December 31, 2005,
  respectively, and
  $53,000 and
  $1,388,000 of non-
  cash stock-based
  expense for the
  three and twelve-
  month periods
  ended December 31,
  2004,
  respectively)       2,266,318   4,066,409    9,087,270    9,034,855
 Depreciation and
  amortization           58,610      30,215      217,095      103,851
 Common stock, stock
  options and
  warrants issued
  for general and
  administrative
  services               24,191   1,037,729      366,753    1,977,330
 General and
  administrative      1,470,551     780,868    6,057,353    5,923,910
                    --------------------------------------------------
                      3,819,670   5,915,221   15,728,471   17,039,946
                    --------------------------------------------------
Loss before other
 income              (3,646,810) (5,815,221) (15,544,111) (16,611,782)
Other income:
 Gain on lease
  termination                --          --      163,604           --
 Interest income         82,045       9,229      206,195       59,977
 Minority interest
  in losses of
  subsidiary                 --      44,006       81,452      159,616
                    --------------------------------------------------
Net loss            $(3,564,765)$(5,761,986)$(15,092,860)$(16,392,189)
                    ==================================================
Basic and diluted:
    Loss per common
     share               $(0.06)     $(0.15)      $(0.27)      $(0.48)
                    ==================================================
    Weighted
     average shares
     outstanding     58,290,651  39,555,872   56,852,402   34,325,636
                    ==================================================