Cyberkinetics to Participate in NIH Grant for Development of Implants for Restoring Neurological Function.$6.5 Million, Five-Year Grant Advances BrainGate Technology to Help Paralyzed par·a·lyze
tr.v. par·a·lyzed, par·a·lyz·ing, par·a·lyz·es
1. To affect with paralysis; cause to be paralytic.
2. To make unable to move or act: paralyzed by fear. People Regain Lost Function
FOXBOROUGH, Mass.; PROVIDENCE, R.I. and CLEVELAND -- Cyberkinetics Neurotechnology Systems, Inc. (OTCBB OTCBB
See OTC Bulletin Board (OTCBB). : CYKN; "Cyberkinetics"), Brown University, and the Cleveland FES (Functional Electrical Stimulation Functional electrical stimulation (commonly abbreviated as FES) is a technique that uses electrical currents to activate nerves innervating extremities affected by paralysis resulting from spinal cord injury (SCI), head injury, stroke or other neurological disorders, ) Center at the Case Western Reserve University announced that they will act as a consortium pursuant to a five-year, $6.5 million grant from the National Institutes of Health (NIH "Not invented here." See digispeak.
NIH - The United States National Institutes of Health. ) to support the development of Cyberkinetics' BrainGate Neural Interface System (BrainGate System). The grant was awarded by the National Institute of Biomedical bi·o·med·i·cal
1. Of or relating to biomedicine.
2. Of, relating to, or involving biological, medical, and physical sciences. Imaging and Bioengineering bioengineering
Application of engineering principles and equipment to biology and medicine. It includes the development and fabrication of life-support systems for underwater and space exploration, devices for medical treatment (see and the National Institute of Child Health and Human Development, both constituents of the NIH. The goal of the BrainGate System is to provide a reliable, fully implantable and wireless neuroprosthesis that enables paralyzed people to use their own limbs to perform tasks such as eating, drinking, and controlled breathing, as well as to regain bowel and bladder function.
According to according to
1. As stated or indicated by; on the authority of: according to historians.
2. In keeping with: according to instructions.
3. the terms of the grant, Cyberkinetics may receive up to $2.5 million of the total grant award during the five-year period covered by the agreement. The grant represents non-dilutive funding for the development of the BrainGate System.
"We are extremely gratified grat·i·fy
tr.v. grat·i·fied, grat·i·fy·ing, grat·i·fies
1. To please or satisfy: His achievement gratified his father. See Synonyms at please.
2. that the NIH recognizes that the BrainGate technology holds promise in the effort to improve the lives of people with central nervous system injuries and disorders," noted John P. Donoghue John P. Donoghue (born 1957) is an American politician from Maryland and a member of the Democratic Party. He is currently serving in his 5th term in the Maryland House of Delegates, representing Maryland's District 2C in Washington County. , Ph.D., Chief Scientific Officer of Cyberkinetics and Director of the Brain Science Program at Brown University. "Having already demonstrated proof-of-concept for the BrainGate technology to enable paralyzed people to control a wide range of external devices for enhancing independence and increasing mobility, this grant is designed to further develop the BrainGate implant."
"This award is an important step in Cyberkinetics' strategy to utilize non-dilutive grant funding to support development of the BrainGate technology," added Timothy R. Surgenor, President and Chief Executive Officer of Cyberkinetics. "We believe this grant, the second major NIH grant award for the BrainGate System developed by Brown University and Cyberkinetics, is a significant endorsement by the NIH. The award underscores the potential value of our technology to someday offer paralyzed people increased independence and control of their lives."
"The Cleveland FES Center The Cleveland FES Center provides a critical mass dedicated to the advancement of neuro-augmentation and neuro-prosthetic solutions, developing technological solutions that improve the quality of life of individuals with neruological or musculoskeletal impairments through the use of , through collaborative projects, advances the study and integration of FES technologies, and applies them to real human needs," stated P. Hunter Peckham, Ph.D., Executive Director of the Cleveland FES Center and Professor of Biomedical Engineering Biomedical engineering
An interdisciplinary field in which the principles, laws, and techniques of engineering, physics, chemistry, and other physical sciences are applied to facilitate progress in medicine, biology, and other life sciences. and Orthopaedics at Case Western Reserve University. "It is heartwarming heart·warm·ing or heart-warm·ing
1. Causing gladness and pleasure.
2. Eliciting sympathy and tender feelings: a heartwarming tale.
Adj. 1. to hear the personal stories from research volunteers with FES implants whose quality of life is tremendously improved with restored function."
About the BrainGate Neural Interface System
The BrainGate Neural Interface System is a proprietary, investigational brain-computer interface (BCI BCI Bat Conservation International
BCI Brain-Computer Interface
BCI Business Continuity Institute
BCI Business Cycle Indicators
BCI Banco de Credito e Inversiones (Chilean bank)
BCI Bell Canada International ) consisting of an internal sensor to detect brain cell activity and external processors that convert brain signals into a computer-mediated output under the person's own control. The sensor is a tiny silicon chip about the size of a baby aspirin baby aspirin Therapeutics A popular term for a formulation that contains 81 or less mg of aspirin, used to ↓ blood coagulability. See Aspirin. with one hundred electrodes, each thinner than a human hair, that can detect the electrical activity of neurons. The sensor is implanted on the area of the brain responsible for movement, the motor cortex motor cortex
The region of the cerebral cortex influencing movements of the face, neck and trunk, and arm and leg. Also called excitable area, motor area, Rolando's area. , where it detects and transmits neural signals to computers that analyze the signals.
The ultimate goal of the BrainGate System development program is to create a safe, effective and unobtrusive universal operating system to enable those with motor impairments to quickly and reliably control a wide range of devices, including computers, assistive technologies and medical devices, simply by thinking. In addition, the underlying neural sensing technology is being developed to enable detection, prediction and prevention of epileptic seizures. The fundamental groundwork for this human clinical work was conducted in the Donoghue Lab at Brown University and made possible by preclinical funding from the National Institute of Neurological Disorders and Stroke The National Institute of Neurological Disorders and Stroke is a part of the U.S. National Institutes of Health.
The NINDS conducts and supports research on brain and nervous system disorders. Created by the U.S. .
Through funding from the National Center for Medical Rehabilitation Research and the National Institute of Child Health and Human Development, Cyberkinetics is already working with collaborators at Case Western Reserve University and the Cleveland FES Center to develop a neuroprosthesis designed to work with the BrainGate System to restore partial arm and hand function to individuals with paralysis caused by spinal cord injury Spinal Cord Injury Definition
Spinal cord injury is damage to the spinal cord that causes loss of sensation and motor control.
Approximately 10,000 new spinal cord injuries (SCIs) occur each year in the United States. .
About FES (Functional Electrical Stimulation)
FES is a method of applying low level electrical currents to the body to restore or improve function. A heart pacemaker is one example of an FES System. Another example of an FES System is one which employs an electrical current to restore movement by initiating muscle contractions in paralyzed extremities. The main components of an FES system are the electrodes, the stimulator, and sensors or switches. When FES is used to move muscles, current that pulses in the electrodes causes the weakened or paralyzed muscles to contract. Electrodes may be placed on the surface of the skin or implanted under the skin. The stimulator controls the strength and timing of the low-level pulses that flow to the electrodes. The sensors or switches control the starting and stopping of the pulses supplied by the stimulator. To be truly practical, an FES system needs to correct for changes in the environment and day-to-day changes in the user's body via a feedback method that can adjust the stimulation so that it accomplishes the desired movement. Some FES systems are currently available to consumers, others are undergoing clinical evaluation clinical evaluation Medtalk An evaluation of whether a Pt has symptoms of a disease, is responding to treatment, or is having adverse reactions to therapy , and many are still in development. In the future, neuroprosthetic devices such as the one being developed under this contract will combine FES technology with direct control by the human brain to offer a fully functioning closed loop limb movement system for persons with upper extremity upper extremity
The shoulder, arm, forearm, wrist, or hand. Also called superior limb, thoracic limb. paralysis.
About the Cleveland FES Center
The Cleveland Functional Electrical Stimulation (FES) Center, a consortium of the Department of Veterans Affairs, Case Western Reserve University, and MetroHealth Medical Center, provides innovative options for restoring neurological health and function by developing advanced technologies and integrating them into clinical care. The Center's focus is to improve people's lives by supporting fundamental research in the neuro-muscular sciences, developing new technologies and methods, performing clinical evaluation and feasibility testing, and promoting the wide-spread deployment of new technologies through professional education and commercial partnerships. More information about the Cleveland FES Center is available at http://fescenter.case.edu.
About Cyberkinetics Neurotechnology Systems, Inc.
Cyberkinetics Neurotechnology Systems, Inc., a leader in the neurotechnology industry, is developing neural stimulation, sensing and processing technology to improve the lives of those with severe paralysis resulting from spinal cord injuries, neurological disorders and other conditions of the nervous system. Cyberkinetics' product development pipeline includes: Andara[TM] OFS (OFS, Norcross, GA, www.ofsbrightwave.com) A manufacturer of optical fibers and interconnect equipment. Formerly the Optical Fiber Solutions (OFS) Group of Lucent, OFS was turned into a stand-alone company acquired by Furukawa Electric in 2001. [TM] Therapy for acute spinal cord injury, an investigative device designed to stimulate nerve repair and restore sensation and motor function; the BrainGate System, an investigative device designed to provide communication and control of a computer, assistive devices, and, ultimately, limb movement; and a pilot program in the detection and prediction of seizures due to Epilepsy. Additional information is available at Cyberkinetics' website at http://www.cyberkineticsinc.com.
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