CritiTech, Inc. Reports That Its Nano-Formulation of Paclitaxel is More Effective Than the Conventional Paclitaxel in a Mouse Model of Ovarian Cancer.Business Editors/Health & Medical Writers LAWRENCE, Kan.--(BW HealthWire)--March 26, 2002 CritiTech today reported on the first animal data studying its proprietary and novel nano-particle preparation of paclitaxel paclitaxel /pac·li·tax·el/ (pak?li-tak´sel) an antineoplastic that promotes and stabilizes polymerization of microtubules, isolated from the Pacific yew tree (Taxus brevifolia); . In a presentation today at the American Society of Clinical Pharmacology Clinical pharmacology is the science of drugs and their clinical use. It is underpinned by the basic science of pharmacology, with added focus on the application of pharmacological principles and methods in the real world. Therapeutics Annual Meeting in Atlanta, Georgia, March 24-27, 2002, Dr. Kathy Roby, Research Associate Professor of the Department of Anatomy and Cell Biology Cell biology The study of the activities, functions, properties, and structures of cells. Cells were discovered in the middle of the seventeenth century after the microscope was invented. , and an Associate Director of the Cell and Tissue Culture Core at the Center for Reproductive Sciences, at the University of Kansas The University of Kansas (often referred to as KU or just Kansas) is an institution of higher learning in Lawrence, Kansas. The main campus resides atop Mount Oread. Medical Center in Kansas City, Kansas Kansas City, Kansas (KCK) is the third largest city in the U.S. state of Kansas and the county seat of Wyandotte County (WyCo); it is part of the "Unified Government"[2] which also includes the cities of Bonner Springs and Edwardsville. , reported on enhanced survival in mice treated with CritiTech's nanopaclitaxel versus those treated with conventional paclitaxel. CritiTech's nanoparticulate paclitaxel significantly increased survival compared to control and paclitaxel-treated mice. Control mice survived 87 days and paclitaxel-treated mice survived 105 days. Significantly, up to 50% of the mice in the nanoparticulate paclitaxel groups were surviving at 162 days. Furthermore, the mice treated with the nanoparticulate paclitaxel exhibited no apparent toxicity to the highest dose. Treatment with nanoparticulate paclitaxel resulted in increased survival and reduced treatment-related toxicity in a mouse model of ovarian cancer ovarian cancer Malignant tumour of the ovaries. Risk factors include early age of first menstruation (before age 12), late onset of menopause (after age 52), absence of pregnancy, presence of specific genetic mutations, use of fertility drugs, and personal history of breast . Paclitaxel has shown promise in the treatment of ovarian cancer. However, toxicity, in part due to the insoluble nature of paclitaxel, remains a limitation to its use. The studies were undertaken to assess the effectiveness of a novel preparation of nanoparticulate paclitaxel in a mouse model of ovarian cancer. These preliminary data suggest that CritiTech's proprietary nanopaclitaxel formulation may have both safety and efficacy advantages over conventional paclitaxel. For a copy of the full abstract that has been submitted, contact Janet Good at jgood@crititech.com or 785/749-3919. CritiTech is a Kansas corporation currently conducting research and development in the production of fine drug particles, primarily through a process known as Precipitation with Compressed Antisolvent (PCA (tool, programming) PCA - A dynamic analyser from DEC giving information on run-time performance and code use. ). CritiTech has completed research on several compounds to improve water solubility by means of drug particle size reduction. This particle size reduction results in an increase of the effective surface area of the compound, thus enhancing its dissolution rate. |
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