Creatine (Creapure). (Nutraceuticals Research).Nutraceutical: Creatine creatine /cre·a·tine/ (kre´ah-tin) an amino acid occurring in vertebrate tissues, particularly in muscle; phosphorylated creatine is an important storage form of high-energy phosphate. (Creapure[R]) Indication: Myotonic dystrophy Myotonic Dystrophy Definition Myotonic dystrophy is a progressive disease in which the muscles are weak and are slow to relax after contraction. type 1 (DM1) Source: J Neurol 2002 Dec; 249(12):1717-22. Research: The safety and efficacy of creatine monohydrate mon·o·hy·drate n. A compound, such as calcium chloride monohydrate, that contains one molecule of water. (Cr) was assessed in myotonic dystrophy (DM1) in a double-blind, cross-over trial. Thirty-four patients with defined DM1 were randomized ran·dom·ize tr.v. ran·dom·ized, ran·dom·iz·ing, ran·dom·iz·es To make random in arrangement, especially in order to control the variables in an experiment. to receive Cr and placebo for eight weeks (10.6 g day 1-10, 5.3 g day 11-56) in one of two treatment sequences. Results: There was no significant improvement using manual and quantitative muscle strength, daily life activities and patients' own global assessment comparing verum with placebo administration. Cr supplementation was well tolerated without clinically relevant side effects, but did not result in significant improvement of muscle strength or daily-life activities. |
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