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Corixa Announces Restructuring of Its South San Francisco Operations.


Business Editors, Health/Medical Writers

SEATTLE--(BW HealthWire)--May 23, 2002

Company to Focus Resources on Core Immunotherapeutic Development

Efforts and Related Operations

Corixa Corp. (Nasdaq:CRXA), a developer of immunotherapeutics, today announced the restructuring of its South San Francisco South San Francisco, city (1990 pop. 54,312), San Mateo co., W Calif.; inc. 1908. South San Francisco has several industrial parks; its manufactures include medical supplies and equipment, foods, paint, paper products, consumer goods, and clothing.  operations.

As a result of the restructuring, Corixa also announced:
-- The purchase of specific preclinical assets by Medarex, and associated
transfer of approximately 30 Corixa employees to Medarex to support those
programs (announced in a separate press release today)

-- An approximate 60 percent immediate reduction in Corixa's South San
Francisco workforce, including the elimination of unfilled open positions, as
well as select existing positions and those transferred to Medarex. Certain
additional South San Francisco employees will be retained for a short
transition period, and additional South San Francisco employees will be offered
positions at other Corixa locations.


These business decisions support Corixa's goal of focusing staff and financial resources on core immunotherapeutic development efforts and related operations.

The workforce reductions announced today will result in a second quarter charge of up to $2.5 million. In addition, Corixa expects to incur additional charges related to its leased facilities as it enters into potential sublease sublease n. the lease of all or a portion of premises by a tenant who has leased the premises from the owner. A sublease may be prohibited by the original lease, or require written permission from the owner.  arrangements. The workforce reduction and asset sale and related employee transfer are expected to result in annual cost savings of more than $30 million. Following the reductions announced today, Corixa will have approximately 375 employees at facilities in Seattle, South San Francisco and Hamilton, Montana Hamilton is a city in Ravalli County, Montana, United States. The population was 3,705 at the 2000 census. It is the county seat of Ravalli CountyGR6. History
Hamilton was founded by copper king Marcus Daly in the late 19th century.
.

"The actions taken today will help us focus on programs that we consider key to our success, including cancer and infectious disease Infectious disease

A pathological condition spread among biological species. Infectious diseases, although varied in their effects, are always associated with viruses, bacteria, fungi, protozoa, multicellular parasites and aberrant proteins known as prions.
 vaccines, selected antibodies, our growing adjuvant adjuvant /ad·ju·vant/ (aj?dbobr-vant) (a-joo´vant)
1. assisting or aiding.

2. a substance that aids another, such as an auxiliary remedy.

3.
 business, AGPs as monotherapies and rational treatments for autoimmune disease autoimmune disease, any of a number of abnormal conditions caused when the body produces antibodies to its own substances. In rheumatoid arthritis, a group of antibody molecules called collectively RF, or rheumatoid factor, is complexed to the individual's own gamma ," stated Steven Gillis, Ph.D. chairman and chief executive officer. "Further concentration of our efforts in these areas will strengthen our balance sheet and allow us to pursue priority programs more aggressively and efficiently."

Gillis added, "We will consolidate bench research and development operations at our Seattle facility. Our Montana location will continue to function as a manufacturing site for our adjuvant and AGP (Accelerated Graphics Port) A high-speed 32-bit port from Intel for attaching a display adapter to a PC. It provides a direct connection between the card and memory, and only one AGP slot is on the motherboard.  product lines, as well as selected fermentation-derived vaccines. The clinical and regulatory affairs Regulatory Affairs (RA), also called Government Affairs, is a profession within regulated industries, such as pharmaceuticals, medical devices, energy, and banking. Regulatory Affairs professionals usually have responsibility for the following general areas:
 teams in South San Francisco, both of which have been largely re-structured following the Coulter acquisition, will remain intact. The South San Francisco operation will also house key individuals responsible for various aspects of BEXXAR(R) manufacturing and logistics. While some staff at other locations will be asked to take over certain responsibilities associated with process development functions previously conducted in South San Francisco, a few additional employees may be added in the future to assist with these activities. Finally, the sales and marketing positions eliminated as a result of today's restructuring may be re-instated in the future, if developments merit."

The company is currently evaluating use of more cost effective facilities to accommodate the remaining employees in South San Francisco and is involved in active discussions regarding additional sublease agreements for Corixa's remaining facilities located at 600 and 630 Gateway Blvd. As a part of the agreement with Medarex, Medarex has agreed to sublease approximately 30,000 square feet of laboratory and office space at Corixa's South San Francisco 650 Gateway Blvd. facility subject to customary conditions.

Conference Call

Corixa will hold a conference call on May 24, 2002 at 8:30 a.m. EST EST electroshock therapy.

EST
abbr.
electroshock therapy
 to discuss today's announcements. To participate in the conference call, participants should dial 800-289-0496 (international dial 913-981-5519). A replay of the conference call will be available from 11:30 a.m. EST May 24th through midnight May 28th. To access the replay, please dial 888-203-1112 (international dial 719-457-0820), and enter passcode 366160. Or you can visit the investors section of Corixa's website at www.corixa.com.

About Corixa

Corixa is a developer of immunotherapeutics with a commitment to treating and preventing autoimmune diseases Autoimmune diseases
A group of diseases, like rheumatoid arthritis and systemic lupus erythematosus, in which immune cells turn on the body, attacking various tissues and organs.

Mentioned in: Complement Deficiencies, Premature Menopause
, cancer and infectious diseases infectious diseases: see communicable diseases.  by understanding and directing the immune system immune system

Cells, cell products, organs, and structures of the body involved in the detection and destruction of foreign invaders, such as bacteria, viruses, and cancer cells. Immunity is based on the system's ability to launch a defense against such invaders.
. Corixa is focused on immunotherapeutic products and has a broad technology platform enabling both fully integrated vaccine design and the use of its separate, proprietary product components on a standalone basis. Corixa currently has 18 programs in clinical development.

The company partners with numerous developers and marketers of pharmaceuticals, targeting products that are Powered by Corixa(TM) technology with the goal of making its potential products available to patients around the world. Corixa was founded in 1994 and is headquartered in Seattle, with additional operations in Hamilton, Mont., and South San Francisco. For more information, please visit Corixa's Web site at http://www.corixa.com/ or call the company's investor relations Investor relations

The process by which the corporation communicates with its investors.
 information line at 877-4CORIXA or 877-426-7492.

Corixa Forward Looking Statements

Except for the historical information presented, certain matters discussed in this press release are forward-looking statements forward-looking statement

A projected financial statement based on management expectations. A forward-looking statement involves risks with regard to the accuracy of assumptions underlying the projections.
. Forward-looking statements are based on the opinions and estimates of management at the time the statements are made. They are subject to certain risks and uncertainties that could cause actual results to differ materially from any future results, performance or achievements expressed or implied by such statements. Factors that could affect Corixa's actual results include, but are not limited to the currently projected cost savings associated with today's announcement not being achieved and the "Factors Affecting Our Operating Results, Our Business and Our Stock Price," described in Corixa's Quarterly Report on Form 10-Q Form 10-Q

See 10-Q.
 for the quarter ended March 31, 2002, copies of which are available from Corixa's investor relations department. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this release.
COPYRIGHT 2002 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2002, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Comment:Corixa Announces Restructuring of Its South San Francisco Operations.
Publication:Business Wire
Geographic Code:1USA
Date:May 23, 2002
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