Comparative Mouse Genomics Centers Consortium (CMGCC): mouse models to improve understanding of the biological significance of human polymorphisms.The CMGCC is a multidisciplinary, multi-institutional component of the Environmental Genome Project genome project 1 The Human Genome Project, see there 2. A general term for a coordinated research initiative for mapping and sequencing the genome of any organism (EGP (1) (Exterior Gateway Protocol) A broad category of routing protocols that are designed to span different autonomous systems. Contrast with IGP. (2) (Exterior Gateway P ). This program commenced in 2001 to develop resources in transgenic trans·ge·nic adj. 1. Of, relating to, or being an organism whose genome has been altered by the transfer of a gene or genes from another species or breed: transgenic mice. 2. and knockout mouse knock·out mouse n. A transgenic mouse that has been genetically engineered to exhibit mutations in specific genes. models based on single nucleotide polymorphisms Noun 1. single nucleotide polymorphism - (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is altered; SNPs are usually considered to be point mutations that have been evolutionarily successful enough to recur in a (SNPs) in human environmentally responsive genes. The specific goals of the CMGCC are to * identify functional SNPs that are relevant to human environmental health; * develop transgenic and knockout mouse models based on functional human SNPs in environmental response genes; * validate mouse models by genotypic genotypic emanating from or pertaining to genotype. genotypic selection selection of breeding stock on the basis of known inherited characteristics. and phenotypic phe·no·type n. 1. a. The observable physical or biochemical characteristics of an organism, as determined by both genetic makeup and environmental influences. b. characterizations; * understand the mechanism(s) of SNP SNP Scottish National Party Noun 1. SNP - (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is altered; SNPs are usually considered to be point mutations that have been evolutionarily functionality and its relationship to disease susceptibility through exposure assessment studies on variant mouse models; and * develop databases that incorporate findings and share information and resources with the scientific community. Currently, the CMGCC has 54 transgenic or knockout mouse models at varying stages of construction and characterization (with regard to genotyping Genotyping refers to the process of determining the genotype of an individual with a biological assay. Current methods of doing this include PCR, DNA sequencing, and hybridization to DNA microarrays or beads. and phenoytping) for use as SNPs mice. Mouse repositories housing available mouse lines are the Mutant Mouse Regional Repository Centers (MMRRC MMRRC Mutant Mouse Regional Resource Center ) (http://www.mmrrc.org/index.html) and the Mouse Models of Human Cancer Consortium Mouse Repository (MMHCC) (http://mouse.ncifcrf.gov/). The 19 mouse models available from either the MMHCC or the MMRRC are listed in the table below. There are an additional 19 mouse models available directly from CMGCC investigators. Contact Frederick Tyson, PhD | tyson2@niehs.nih.gov
Gene/polymorphism Mutation type
ATM Deletion mutation
mCAT Transgenic, mitochondrial targeted
WRN (K577M) Transgenic, SNP
Tcra/Tcrb Tg Transgenic point mutation
CycD1bK5(A870G/exon5) SNP transgenic
P53 (R270H) Conditional SNP
Fen1 Deletion mutation by gene targeting
creK5 Transgenic conditional Cre system
XpaCre Conditional deletion mutation by gene
targeting
P58ipk(tm-gfp) Deletion mutation by gene targeting
HB-Plap (AtoG) Transgenic
Mlh1\ Deletion mutation by gene targeting
Msh2 Deletion mutation by gene targeting
Msh3 Deletion mutation by gene targeting
Msh6 Deletion mutation by gene targeting
Aprt Deletion mutation by gene targeting
HB-Plap (G11) Transgenic
HB-Plap Transgenic
Prkr (TAG70) Transgenic, CMV
Projected use Status Repository
Deletion assessment Available MMRRC
Oxidative stress Available MMRRC
SNP assessment, cancer, diabetes Available MMRRC
Rheumatoid arthritis Available MMRRC
SNP assessment, skin cancer Available MMRRC
Cancer Available MMHCC (Jacks)
Tool, cancer Available MMHCC
Tool, cancer Available MMRRC
Tool, cancer, aging Available MMRRC
Tool, diabetes Available MMRRC
Tool, frame shift indicator mouse Available MMHCC
Tool, GI cancer Available MMHCC
Tool, GI cancer Available MMHCC
Tool, GI cancer Available MMHCC
Tool, GI cancer Available MMHCC
Tool, LOH indicator mouse Available MMHCC
Tool, transition indicator Available MMHCC
Tool, transition indicator Available MMHCC
Tool, translation regulation of DNA repair Available MMRRC
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