Company Profile for BioLeap, LLC.BioLeap offers a highly cost-effective lead identification and optimization service using the next generation of structure-based design. * BioLeap's technology determines the location, orientation, and binding affinities of chemical moieties in relation to a target protein. These are used to build or modify ligands that achieve design goals such as potency, bioavailability bioavailability /bio·avail·a·bil·i·ty/ (bi?o-ah-val?ah-bil´i-te) the degree to which a drug or other substance becomes available to the target tissue after administration. bi·o·a·vail·a·bil·i·ty n. , selectivity selectivity /se·lec·tiv·i·ty/ (se-lek-tiv´i-te) in pharmacology, the degree to which a dose of a drug produces the desired effect in relation to adverse effects. selectivity 1. , or insensitivity to mutations. * This information allows our chemists to access a very large chemical diversity that is relevant to the target receptor. * By predicting the impact on affinity of chemical modifications In biochemistry, chemical modification is the technique of chemically reacting a protein or nucleic acid with chemical reagents. Chemical modification can have several goals, such as
* With a small number of compounds, it is economical to do a broader range of bioassays, such as in vitro in vitro /in vi·tro/ (in ve´tro) [L.] within a glass; observable in a test tube; in an artificial environment. in vi·tro adj. In an artificial environment outside a living organism. , cell, and ADME ADME Absorption, Distribution, Metabolism, and Excretion ADME Association of Destination Management Executives ADME Active Duty Medical Extension assays, at each stage of optimization. This results in faster optimization and more information from each cycle. Bio-assays early = an immediate focus on drugability = higher success; Less wet chemistry = more "shots on goal" per dollar invested; Without HTS HTS Heights HTS Harmonized Tariff System HTS High Throughput Screening (biomolecular assay screening) HTS High-Throughput Screening (Pharmaceutical Industry) HTS Harmonized Tariff Schedule or virtual library screening.
Company: >
BioLeap, LLC
>
Headquarters Address: >
346A Lurgan Road
>
New Hope, PA 18938
>
Main Telephone: >
2153712874
>
Website: >
www.bioleap.com
>
Type of Organization: >
Private
>
Industry: >
Biotechnology
>
Key Executives: >
EVP: Gerald Evans
>
Public Relations >
Contact: >
Gerry Evans
Phone: >
2153712874
Email: >
ghe@bioleap.com
|
|
||||||||||||
Printer friendly
Cite/link
Email
Feedback
Reader Opinion