Common food additive may increase lung cancer risk.Byline: ANI
Washington, Dec 30 (ANI): A diet high in inorganic phosphates, which are found in a variety of processed foods-including meats, cheeses, beverages, and bakery products-can increase the risk and spread of lung cancer lung cancer, cancer that originates in the tissues of the lungs. Lung cancer is the leading cause of cancer death in the United States in both men and women. Like other cancers, lung cancer occurs after repeated insults to the genetic material of the cell. , according to according to
1. As stated or indicated by; on the authority of: according to historians.
2. In keeping with: according to instructions.
3. a new study.
The study, using a mouse model, indicated that inorganic phosphates might speed growth of lung cancer tumours, and even contribute to the development of those tumours in individuals predisposed pre·dis·pose
v. pre·dis·posed, pre·dis·pos·ing, pre·dis·pos·es
a. To make (someone) inclined to something in advance: to the disease.
Conducted by Myung-Haing Cho, D.V.M., Ph.D., and his colleagues at Seoul National University Not to be confused with the University of Seoul.
Seoul National University (SNU) is a national research university in Seoul, South Korea. Founded in 1946, SNU was the first national university in South Korea, and served as a model for the many national and public , the study also suggested that dietary regulation of inorganic phosphates might play an important role in lung cancer treatment.
"Our study indicates that increased intake of inorganic phosphates strongly stimulates lung cancer development in mice, and suggests that dietary regulation of inorganic phosphates may be critical for lung cancer treatment as well as prevention," said Cho.
The study revealed that high levels of inorganic phosphates can stimulate non-small cell lung cancer Lung Cancer, Non-Small Cell Definition
Non-small cell lung cancer (NSCLC) is a disease in which the cells of the lung tissues grow uncontrollably and form tumors.
There are two kinds of lung cancers, primary and secondary. (NSCLC NSCLC non (or cancer).
NSCLC Non-small cell lung cancer, see there ) pathways.
"Lung cancer is a disease of uncontrolled cell proliferation in lung tissue, and disruption of signaling pathways in those tissues can confer a normal cell with malignant properties. Deregulation Deregulation
The reduction or elimination of government power in a particular industry, usually enacted to create more competition within the industry.
Traditional areas that have been deregulated are the telephone and airline industries. of only a small set of pathways can confer a normal cell with malignant properties, and these pathways are regulated in response to nutrient availability and, consequently, cell proliferation and growth," explained Cho.
He added: "Phosphate is an essential nutrient to living organisms, and can activate some signals. This study demonstrates that high intake of inorganic phosphates may strongly stimulate lung cancer development by altering those (signaling) pathways."
For the study, the researcher analysed lung cancer-model mice for four weeks.
The mice were randomly assigned to receive a diet of either 0.5 or 1.0 percent phosphate, a range roughly equivalent to modern human diets.
After four-weeks, the lung tissue was analysed to determine the effects of the inorganic phosphates on tumours.
"Our results clearly demonstrated that the diet higher in inorganic phosphates caused an increase in the size of the tumours and stimulated growth of the tumours," said Cho.
"The results of this study suggest that dietary regulation of inorganic phosphates has a place in lung cancer treatment, and our eventual goal is to collect sufficient information to accurately assess the risk of these phosphates," he said.
The study has been published in the January issue of the American Journal of Respiratory and Critical Care Medicine. (ANI)
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