Coming soon, a sureshot way to treat constipation.Byline: ANI Washington, April 9 (ANI): Suffering from constipation? Well, help is on the way - a team of researchers has identified a potential drug target to make it a lot easier to go to the bathroom, especially when all other methods fail. They have discovered a group of nerve ending receptors, which, when stimulated, causes the bowels to pass waste, and the specific receptor needed to activate bowel clearance. Also, they tested chemicals that work with those receptors, providing a blueprint for the development of new laxatives Laxatives Definition Laxatives are products that promote bowel movements. Purpose Laxatives are used to treat constipation—the passage of small amounts of hard, dry stools, usually fewer than three times a week. . "We hope that the receptor identified by our study would be exploited more in the design of drugs to treat constipation," said Bindu Chandrasekharan, a researcher from Emory University Emory University (ĕm`ərē), near Atlanta, Ga.; coeducational; United Methodist; chartered as Emory College 1836, opened 1837 at Oxford. It became Emory Univ. in 1915 and in 1919 moved to Atlanta. who was involved in the study. The study involved two groups of mice, focusing on a type of receptor also present on human nerves
The adenosine A1 receptor has been found to be ubiquitous throughout the entire body. ). The first group of mice had normal adenosine receptors on these nerves and normal bowel movements. The second group of mice completely lacked these adenosine receptors and showed familiar signs of constipation. The researchers started with simple experiments such as comparing the wet weight, dry weight, and water content in the stools of both groups. The mice were also made to drink a dye not absorbed by the body to see how it passed or did not pass. In addition, the researchers used microscopic lasers to separate the nerve cells nerve cell n. 1. See neuron. 2. The body of a neuron without its axon and dendrites. from the bowel to determine exactly where the receptors are located. Then they tested various chemicals that can activate or inhibit the nerve receptors. Gerald Weissmann, M.D, Editor-in-Chief of The FASEB FASEB Federation of American Societies for Experimental Biology Journal, said: "Here's why: First, we can look forward to a solution to what is sometimes a serious problem, especially infants and the elderly. Second, it's the first definitive proof that these receptors, the adenosine receptors, control bowel function. This discovery promises to yield agents that will permit us to sit down and ease up in the middle of a busy day." The study has been published online in The FASEB Journal. (ANI) Copyright 2009 Asian News International The Asian News International (ANI) agency provides multimedia news to China and 50 bureaus in India. It covers virtually all of South Asia since its foundation and presently claims, on its official website, to be the leading South Asia-wide news agency. (ANI) - All Rights Reserved. Provided by Syndigate.info an Albawaba.com company |
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