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CombinatoRx Announces Senior Management Updates.


CAMBRIDGE, Mass. -- CombinatoRx, Incorporated (NASDAQ NASDAQ
 in full National Association of Securities Dealers Automated Quotations

U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on
: CRXX) today announced the promotion of Daniel Grau to the newly created position of Chief Operating Officer Chief Operating Officer (COO)

The officer of a firm responsible for day-to-day management, usually the president or an executive vice-president.
 and the retirement of Dr. Jan Lessem as Chief Medical Officer, effective January 31, 2007.

"It is my pleasure to promote Dan to COO. Our philosophy at CombinatoRx is to promote high achieving senior leaders from within," said Alexis Borisy, President and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. . "Dan has demonstrated his leadership at CombinatoRx across multiple important disciplines at the company and has played a key role in building our product portfolio to where we are today. I feel fortunate to have such a strong management team."

As Chief Operating Officer, Daniel Grau will be responsible for the areas of therapeutic program management, new products, strategic marketing, medical affairs, business development, alliance management and informatics Same as information technology and information systems. The term is more widely used in Europe. . He will continue to report to Alexis Borisy, President and CEO. Mr. Grau has been a key member of the CombinatoRx management team, most recently as Senior Vice President of Commercial Operations. In addition to his role in the operations of the business, he also negotiated a broad portfolio of deals that have provided the Company with significant R&D funding and product rights. He joined CombinatoRx in 2001 with diverse experiences ranging from pharmaceutical marketing, new product launch, lifecycle management and business development. Mr. Grau earned his B.A. from Davidson College Davidson College

Private liberal arts college in Davidson, North Carolina, U.S., founded in 1837. It is affiliated with the Presbyterian church, though its approach to learning is nonsectarian. Women were first admitted in 1972.
, holds M.A., M.A.R. and M.Phil. degrees from Yale University Yale University, at New Haven, Conn.; coeducational. Chartered as a collegiate school for men in 1701 largely as a result of the efforts of James Pierpont, it opened at Killingworth (now Clinton) in 1702, moved (1707) to Saybrook (now Old Saybrook), and in 1716 was  and is the recipient of the Andrew J. Mellon Fellowship in the Humanities.

Jan Lessem, M.D., Ph.D. has made significant contributions in his role as Chief Medical Officer. Dr. Lessem was instrumental in the advancement of CombinatoRx from a start-up drug discovery company to an organization with an extensive clinical product portfolio. Under his leadership, the Company has moved seven products into Phase 2 clinical development in three years. Dr. Lessem will continue as a consultant to CombinatoRx.

"I am thankful to Dr. Lessem for his years of dedication and service to CombinatoRx and am pleased to have his ongoing involvement in the Company beyond his retirement," said Alexis Borisy, President and CEO.

About CombinatoRx

CombinatoRx, Incorporated (CRXX) is pioneering the new field of synergistic synergistic /syn·er·gis·tic/ (sin?er-jis´tik)
1. acting together.

2. enhancing the effect of another force or agent.


syn·er·gis·tic
adj.
1.
 combination pharmaceuticals and has a broad product portfolio in phase 2 clinical development. Going beyond traditional combinations, CombinatoRx creates product candidates with novel mechanisms of action striking at the biological complexities of human disease. The lead programs in the CombinatoRx portfolio are advancing into later stage clinical trials based on the strength of multiple positive phase 2a trial results. This portfolio is internally generated from the CombinatoRx proprietary drug discovery technology which provides a renewable and previously untapped source of novel drug candidates. The Company was founded in 2000 and is located in Cambridge, Massachusetts This article is about the city of Cambridge in Massachusetts. For the English university town, see Cambridge, England. For other places, see Cambridge (disambiguation).
Cambridge, Massachusetts is a city in the Greater Boston area of Massachusetts, United States.
. To learn more about CombinatoRx please visit www.combinatorx.com.

Forward-Looking Statement forward-looking statement

A projected financial statement based on management expectations. A forward-looking statement involves risks with regard to the accuracy of assumptions underlying the projections.
 

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  of 1995 concerning CombinatoRx, its product candidates and their clinical potential, its plans for its product candidates, its formulation efforts, its business plans and its drug discovery technology. These forward-looking statements about future expectations, plans and prospects of CombinatoRx involve significant risks, uncertainties and assumptions, including risks related to the unproven unproven Dubious, nonscientific, not proven, quack, questionable, unscientific adjective Relating to that which has not been validated by reproducible experiments or other scientific methods for determining effect or efficacy  nature of the CombinatoRx drug discovery technology, the Company's ability to initiate and successfully complete clinical trials of its product candidates, risks associated with developing modified-release formulations of its product candidates, assumptions regarding the mechanism of action of our product candidates, potential difficulty and delays in obtaining regulatory approval for the sale and marketing of its product candidates, the Company's ability to obtain additional funding for its research and development and those other risks that can be found in the "Risk Factors" section of the CombinatoRx Annual Report Form 10-K Form 10-K

A report required by the SEC from exchange-listed companies that provides for annual disclosure of certain financial information.


Form 10-K

See 10-K.
 on file with the Securities and Exchange Commission and the other reports that CombinatoRx periodically files with the Securities and Exchange Commission. Actual results may differ materially from those CombinatoRx contemplated by these forward looking statements. CombinatoRx does not undertake to update any of these forward-looking statements to reflect a change in its views or events or circumstances that occur after the date of this release.

[c] 2007 CombinatoRx, Incorporated. All rights reserved.
COPYRIGHT 2007 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2007, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:Jan 16, 2007
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