CombiMatrix Announces Commercial Launch of CustomArray, a Fully Customizable DNA Array Platform.Business Editors/Health/Medical Writers BIOWIRE2K NEWPORT BEACH Newport Beach, residential and resort city (1990 pop. 66,643), Orange co., S Calif., on Newport Bay and the Pacific Ocean; inc. 1906. It is a popular seaside resort and yachting center. Manufactures include electrical and medical equipment, computers, boats, and adhesives. , Calif.--(BUSINESS WIRE)--Nov. 6, 2003 Acacia Research Corporation (Nasdaq:CBMX)(Nasdaq:ACTG ACTG Acting ACTG AIDS Clinical Trial Group ACTG Actuating/Actuator ) announced today that its CombiMatrix Group will launch CustomArray(TM), the first fully customizable DNA microarray DNA microarray A small solid support, usually a membrane or glass slide, on which sequences of DNA are fixed in an orderly arrangement. DNA microarrays are used for rapid surveys of the expression of many genes simultaneously, as the sequences contained on a platform, in the first quarter of 2004. A select group of beta customers will be provided CustomArray(TM) products in the 4th quarter of 2003, and these products will be available to the worldwide life sciences community in March 2004. "The CustomArray(TM) microarray platform provides fast turnaround of new, custom designed microarrays allowing users to maintain critical research momentum," said Dr. Amit Kumar, President and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. of CombiMatrix. "Flexibility to change array content rapidly will support pharmaceutical, biotechnology and diagnostic companies to more efficiently identify, assess, and validate new drug candidates or biological markers for further development." CustomArrays(TM) are semiconductor based arrays (approx. 1cm2) integrated on a standard 1" x 3" slide format. CustomArrays(TM) contain in-situ synthesized oligonucleotides, prepared using CombiMatrix's patented virtual flask technology. CustomArrays(TM) require standard hybridization hybridization /hy·brid·iza·tion/ (hi?brid-i-za´shun) 1. crossbreeding; the act or process of producing hybrids. 2. molecular hybridization 3. techniques and can be read with most commercial fluorescent detection reader systems. CustomArrays(TM) will initially be offered with 1,000 sites followed by 13,000 sites per 1cm2, anticipated to be released in the 2nd quarter of 2004. CombiMatrix custom arrays can be delivered to customers within a few days. Customers will have the ability to order fully customizable arrays in quantities as small as a single array. CustomArray(TM) features the following unique characteristics: -- No upfront subscription, special equipment, or design fees -- Any genome (over 1,100 organisms have been sequenced) -- Any genes or probe sequences -- Oligonucleotide lengths of choice -- Multiple genomes on the same chip -- Multiple oligonucleotide lengths on the same chip -- Many other customizable parameters are also available In addition to the CustomArray(TM) platform, CombiMatrix will also offer a series of catalog arrays. Customers will have access to CombiMatrix's suite of software applications for probe design, probe layout, and data extraction Data extraction is the act or process of retrieving (binary) data out of (usually unstructured or badly structured) data sources for further data processing or data storage (data migration). . Target Specifier(TM) software allows the user to specify lists of probes that will be built on an array. The user can drag and drop A graphical user interface (GUI) capability that lets you perform operations by moving the icon of an object with the mouse into another window or onto another icon. For example, files can be copied or moved by dragging them from one folder to another. files to specify lists of their own custom probes. They can also specify lists of genes for which they would like probes designed, and the Probe-Design System(TM) will automatically design probes according to according to prep. 1. As stated or indicated by; on the authority of: according to historians. 2. In keeping with: according to instructions. 3. various user-selected parameters such as length and melting temperature Melting temperature may refer to:
In the future, CombiMatrix will make available desktop array synthesizers for sites that want in-house array production capability. ABOUT ACACIA RESEARCH CORPORATION Acacia Research Corporation comprises two operating groups, Acacia Technologies
The CombiMatrix group is developing a platform technology to rapidly produce customizable active biochips, which are semiconductor-based tools for use in identifying and determining the roles of genes, gene mutations and proteins. CombiMatrix's technology has a wide range of applications including DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. synthesis/diagnostics, siRNA synthesis, drug discovery, and immunochemical im·mu·no·chem·is·try n. The chemistry of immunologic phenomena, as of antigen-antibody reactions. im detection. CombiMatrix provides DNA arrays to researchers under the CustomArray(TM) brand. CombiMatrix's Express Track(sm) drug discovery program is a systems biology approach, using its technology, to target common viral diseases with siRNA compounds. The initial focus of Express Track(sm) are the following viral diseases: Virus Collaborator SARS NIAID/USAMRIID HIV type 1 irsiCaixa -- Dr. Bonaventura Clotet HIV type 2 To Be Announced West Nile virus To Be Announced Human Papillomavirus type 16 To Be Announced Human Herpes 8 (Kaposi's sarcoma) To Be Announced Smallpox (Variola) To Be Announced Influenza virus A To Be Announced Influenza virus B To Be Announced Hepatitis C To Be Announced CombiMatrix is also establishing applications of its arrays through other partnerships as follows:
Project Collaborator
Cancer Diagnosis (Lymphoma) University of Washington/Rational
Diagnostics
Parasite
Leishmania Seattle Biomedical Research Institute
Trypasonoma Seattle Biomedical Research Institute
The Acacia Technologies group licenses its Digital Media Transmission ("DMT See DSL. ") technology to media and electronics companies. The DMT technology covers the transmission and receipt of digital audio and digital video content, commonly known as audio on-demand, video on-demand, and audio/video streaming, and is supported by 5 U.S. and 17 international patents. Acacia Research-Acacia Technologies (Nasdaq:ACTG) and Acacia Research-CombiMatrix (Nasdaq:CBMX) are both classes of common stock issued by Acacia Research Corporation and are intended to reflect the performance of the respective operating groups and are not issued by the operating groups. Information about Acacia Research Corporation and the Acacia Technologies group is available at www.acaciaresearch.com. Information about the CombiMatrix group is available at www.combimatrix.com. Safe Harbor Safe Harbor 1. A legal provision to reduce or eliminate liability as long as good faith is demonstrated. 2. A form of shark repellent implemented by a target company acquiring a business that is so poorly regulated that the target itself is less attractive. Statement under the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and of 1995: This news release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. These statements are based upon our current expectations and speak only as of the date hereof. Our actual results may differ materially and adversely from those expressed in any forward-looking statements as a result of various factors and uncertainties, including the recent economic slowdown affecting technology companies, our ability to successfully develop products, rapid technological change in our markets, changes in demand for our future products, legislative, regulatory and competitive developments and general economic conditions. Our Annual Report on Form 10-K Form 10-K A report required by the SEC from exchange-listed companies that provides for annual disclosure of certain financial information. Form 10-K See 10-K. , recent and forthcoming Quarterly Reports on Form 10-Q Form 10-Q See 10-Q. , recent Current Reports on Forms 8-K and 8-K/A, and other SEC filings discuss some of the important risk factors that may affect our business, results of operations and financial condition. We undertake no obligation to revise or update publicly any forward-looking statements for any reason. |
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