Cold Spring Harbor Laboratory obtains United States patent.Cold Spring Harbor Laboratory  The Cold Spring Harbor Laboratory (Cold Spring Harbor, NY) has patented
proteins are identified from human breast tumor tumor: see neoplasm. cell lines (MDA-MB-231,
T-47D and T-47D/Met) that interact specifically with the
substrate-trapping mutant (programming) mutant - Microsoft's term for a mutex which is generally used in user mode but can also be used in kernel mode. According to this terminology a mutex is only used in kernel mode.["Microsoft Windows NT Workstation Resource Kit"]. form of Density Enhanced Phosphatase-1 (DEP-1). These proteins include the functional component p120 catenin (p120.sup.ctn), the adaptor protein An adaptor protein is a protein which is accessory to main proteins in a signal transduction pathway. These proteins tend to lack any intrinsic enzymatic activity themselves but instead mediate specific protein-protein interactions that drive the formation of protein complexes. Gab 1, and the HGF/SF receptor Met. The invention relates to isolated complexes comprising DEP-1 polypeptides in specific association with Met, Gab 1, or p120.sup.ctn, identified herein as DEP-1 substrate polypeptides. Screening assays for agents that alter DEP-1 interaction with DEP-1 substrate polypeptides are also disclosed, as are methods for altering biological signals in cells that are transduced via DEP-1 pathways. (US 7,205,121) |
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