Clodronate for the Treatment of Osteoarthritis: Positive Results for Abiogen Pharma.Business Editors & Health/Medical Writers BIOWIRE2K PISA Pisa (pē`sä), city (1991 pop. 98,928), capital of Pisa prov., Tuscany, N central Italy, on the Arno River. It is now c.6 mi (9.7 km) from the Tyrrhenian Sea, which once reached the city. , Italy--(BUSINESS WIRE)--Oct. 2, 2002 Dichloromethylene bisphosphonate (Cl2MBP (Manchester Bus Powered) A synchronous transmission standard used in industrial networks. It provides 31.25 Kbps over a two-wire connection that delivers power in the bus and intrinsic safety. ), or clodronate, is a compound which can, potentially, counteract some pathogenetic factors of osteoarthritis. In the osteoarthritis, hydroxyapatite hydroxyapatite /hy·droxy·ap·a·tite/ (-ap´ah-tit) an inorganic calcium-containing constituent of bone matrix and teeth, imparting rigidity to these structures. crystals also appear to play an important role for the progression of the inflammatory damage. Clodronate, as other bisphosphonates, shares the activities of an inorganic pyrophosphate pyrophosphate /py·ro·phos·phate/ (-fos´fat) a salt of pyrophosphoric acid. py·ro·phos·phate n. Abbr. PP A salt or ester of pyrophosphoric acid. : high affinity for solid phase calcium phosphate and, consequently, for hydroxyapatite. Nevertheless, additional actions on metabolic events in cells involved in the turnover of cartilage, as well as on inflammatory reactions, have been observed. Experimental reports show that clodronate is capable of stimulating the biosynthesis of collagen and proteoglycans proteoglycans (prō´tēōglī´kans), n.pl the mucopolysaccharides bound to protein chains occurring in the extracellular matrix of connective tissue. and to inhibiting both prostaglandins production in calvaria calvaria /cal·va·ria/ (kal-var´e-ah) [L.] the domelike superior portion of the cranium, comprising the superior portions of the frontal, parietal, and occipital bones. cal·var·i·a n. pl. cells cultures and interleukin 1 synthesis in vivo. Moreover, clodronate showed anti-inflammatory properties in adjuvant arthritis model, and reduced free radical production by human activated neutrophils. These experimental results represent the rationale for testing the clinical efficacy and tolerability of locally administered clodronate, in the treatment of osteoarthritis. Some pilot clinical trials have also demonstrated the safety and the potential effectiveness of clodronate in knee osteoarthritis. At present, Abiogen Pharma is commencing phase II clinical development, with the aim of confirming these preliminary positive results. Abiogen Pharma S.p.A has a history of research in Osteoarticular Metabolism, obtaining great success with the discovery of molecules from the Bisphosphonates ( Etidronate, Clodronate, Alendronate alendronate /alen·dro·nate/ (ah-len´dro-nat) a bisphosphonate calcium-regulating agent used in the form of the sodium salt to inhibit the resorption of bone in the treatment of osteitis deformans, osteoporosis, and hypercalcemia related , Neridronate). --30--fg/ne/uk*
CONTACT: Abiogen Pharma S.p.A., Pisa
Fabrizia Stagni, +39.050.3154.265
Fax: +39.050.3154.155
Email: Fabrizia.stagni@abiogen.it
KEYWORD: ITALY INTERNATIONAL EUROPE
INDUSTRY KEYWORD: BIOTECHNOLOGY MEDICAL PHARMACEUTICAL PRODUCT
SOURCE: Abiogen Pharma S.p.A.
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