Clinomics issued patent for frozen tissue microarrays.Clinomics Biosciences, Inc. (Frederick, MD), a leading developer and provider of systems biology Systems biology, a field of study in the biosciences, focuses on the systematic study of complex interactions in biological systems. Particularly from 2000 onwards, the term is used widely in the biosciences, and in a variety of contexts. products and services, announced the issuance of a United States United States, officially United States of America, republic (2005 est. pop. 295,734,000), 3,539,227 sq mi (9,166,598 sq km), North America. The United States is the world's third largest country in population and the fourth largest country in area. patent that enables the design and production, for the first time, of Frozen Tissue Microarrays Tissue microarrays (also TMAs) consist of paraffin blocks in which up to 1000 separate tissue cores are assembled in array fashion to allow simultaneous histological analysis. . (United States Patent 6,534,307). "We are very excited about the issuance of this patent," stated Patrick J. Muraca, Ph.D., Co-founder and President, of Clinomics. "Our patented technology allows Clinomics to accurately, reproducibly and rapidly produce tissue microarrays using frozen tissues, and all the time the tissue samples remain frozen." It has long been known that frozen tissue samples are superior to "fixed" (paraffin-embedded) tissue samples in pharmaceutical research. When human cells in tissue are maintained as frozen, the viability and intactness of the RNA RNA: see nucleic acid. RNA in full ribonucleic acid One of the two main types of nucleic acid (the other being DNA), which functions in cellular protein synthesis in all living cells and replaces DNA as the carrier of genetic , DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. and protein within the tissue is preserved, assuring reliable results when analyzing the tissue for the presence of specific gene and protein "targets." Clinomics is developing Frozen tissue microarrays for a variety of applications, in gene and protein target characterization studies, immunohistochemistry and quantitative genomic genomic pertaining to a genome. genomic clone see clone. genomic DNA the DNA sequences making up the genome of an individual. genomic library see gene bank. analysis. "As a specific example of the utility of our frozen tissue microarrays," continued Dr. Muraca, "when Antibodies are characterized with our frozen tissue microarrays, they will not need to undergo what is known as "antigen retrieval," a process that often causes variation in antibody staining staining /stain·ing/ (stan´ing) 1. artificial coloration of a substance to facilitate examination of tissues, microorganisms, or other cells under the microscope. For various techniques, see under stain. 2. in fixed (paraffin-embedded) tissues." Founded in 1998, Clinomics is a leader in the field of human systems biology -- the development of products and services that give researchers access to biological samples representing a broad base of human disease and conditions, for use in the discovery and characterization of disease-specific gene and protein targets used in Pharmaceutical development. Clinomics Biosciences, Inc. +1-413-445-5599 www.clinomicsbio.com |
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