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Clinical trials really pay off.


A new study finds that large-scale human trials of new treatments in medicine have the potential to pay rich dividends--huge economic benefits from improved quality of life.

S. Claiborne Johnston and his colleagues at the University of California, San Francisco Coordinates:   evaluated all 28 trials that the National Institute of Neurological Diseases Noun 1. neurological disease - a disorder of the nervous system
nervous disorder, neurological disorder

disorder, upset - a physical condition in which there is a disturbance of normal functioning; "the doctor prescribed some medicine for the disorder";
 and Stroke (NINDS NINDS Neurology A multicenter, double blinded, randomized trial–National Institute of Neurological Disorders and Stroke which evaluated the effects of tPA therapy in Pts with stroke. See Thrombolytic therapy, tPA. ) in Bethesda, Md. had ever funded to test the efficacy of new drugs or procedures. They focused on the eight trials for which there were data on a therapy's use and impact. Adding the ensuing en·sue  
intr.v. en·sued, en·su·ing, en·sues
1. To follow as a consequence or result. See Synonyms at follow.

2. To take place subsequently.
 years' cost of the therapies in this group boosted their cumulative total cost to $3.6 billion.

The estimated return on that investment was an additional 470,000 years of improved quality of life for people receiving these treatments, the neurologists This is a list of the most important neurologists, with their dates of birth and death and nationality.
  • Théophile Alajouanine 1890 - 1980 France
  • Alois Alzheimer 1864 - 1915 Germany
  • Joseph Babinski 1857 - 1932 France
  • Wladimir Bechterew 1857 - 1927 Russia
 report in the April 22 Lancet. At $40,000 per year of improved quality of life--a low figure for such estimates by economists--net benefits from just eight trials yielded dividends worth more than $15 billion. The researchers note that the cost of all 28 NINDS trials totaled only $335 million.

"I had assumed there would be some benefit, but I was shocked at how great it was," Johnston says. Indeed, his team found that NINDS' average investment in a trial "was returned through health benefits within 1.2 years" of its completion.--J. R.
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Title Annotation:SCIENCE & SOCIETY
Publication:Science News
Article Type:Brief article
Geographic Code:1USA
Date:May 6, 2006
Words:224
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