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Clinical pharmacology of therapeutic proteins.


Clinical pharmacology of therapeutic proteins.

Ed. by Iftekhar Mahmood.

Pine House Publishers


565 pages




Researchers from the US Food and Drug Administration describe how testing drugs that have been derived from biotechnology differs from testing conventional drugs. They begin by setting out the fundamentals in such areas as pharmacokinetics and pharmacodynamics pharmacodynamics /phar·ma·co·dy·nam·ics/ (-di-nam´iks) the study of the biochemical and physiological effects of drugs and the mechanisms of their actions, including the correlation of their actions and effects with their chemical , analytical methods, allometric scaling allometric scaling

scaling of dose rates of drugs, diet ratios to relative growth and size of each part of the animal, or each animal relative to the others.
, and non-clinical aspects of therapeutic proteins. Then they describe biologic products used in oncology, homeostasis homeostasis

Any self-regulating process by which a biological or mechanical system maintains stability while adjusting to changing conditions. Systems in dynamic equilibrium reach a balance in which internal change continuously compensates for external change in a feedback
, arthritis, and rheumatism rheumatism (r`mətĭzəm), general term for a number of disorders that cause inflammation and pain in muscles, bones, joints, or nerves. ; such types of products as monoclonal antibodies and therapeutic enzymes.

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Publication:SciTech Book News
Article Type:Book Review
Date:Dec 1, 2006
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