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Clinical Data and Duke University in Pharmacogenomics Research and Commercialization Collaboration.


NEWTON, Mass. -- Clinical Data to Non-exclusively Share STRENGTH Studies Data With Duke Researchers in Return for First Right to Negotiate Commercial Licenses

Clinical Data, Inc. (NASDAQ NASDAQ
 in full National Association of Securities Dealers Automated Quotations

U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on
: CLDA CLDA California Lyme Disease Association ), a worldwide leader in providing comprehensive molecular and pharmacogenomics services as well as genetic tests to improve patient care, announced today that it has entered into a 5-year research collaboration agreement with the Institute for Genome Sciences & Policy (IGSP IGSP Institute for Genome Sciences and Policy (Genomics Institute)
IGSP Intercollegiate Graduate Statistics Program
IGSP Intergovernmental Solutions Program
IGSP Independent Gateway Service Provider
) at Duke University. Under terms of the agreement, Clinical Data's PGxHealth division will provide IGSP with non-exclusive, confidential access to its STRENGTH studies conducted to discover genetic variants associated with baseline lipid parameters and the response of these parameters to statins Statins
A class of drugs commonly used to lower LDL cholesterol levels.

Mentioned in: C-Reactive Protein
 (used to treat elevated levels of cholesterol). In return, Clinical Data receives the right to evaluate the commercial potential of any findings derived from studies where either the STRENGTH clinical and/or genetic databases are utilized in IGSP studies. Should Clinical Data be interested in any such findings, the Company also receives first right to negotiate a commercial license relating to relating to relate prepconcernant

relating to relate prepbezüglich +gen, mit Bezug auf +acc 
 any and all of the findings.

Researchers at Duke IGSP are planning a series of studies to find and validate associations between genetic variants and responses to drugs used for dyslipidemia (or "hypercholesterolemia Hypercholesterolemia Definition

Hypercholesterolemia refers to levels of cholesterol in the blood that are higher than normal.
Description

Cholesterol circulates in the blood stream. It is an essential molecule for the human body.
") in a family practice setting and are also carrying out similar studies in the areas of hypertension and asthma. Duke researchers, their staff and named collaborators will use PGxHealth's STRENGTH data to help plan, validate and analyze findings from these studies.

Carol Reed, M.D., Senior Vice President and Chief Medical Officer of Clinical Data, said, "We are very pleased to enter into this agreement with Duke IGSP, a true leader in medical innovations and genomic medicine genomic medicine Molecular medicine The application of molecular methods to clinical medicine; MM encompasses diagnostic methods–eg, Southern, Western, and Northern blot hybridizations, DNA signal amplification by PCR, and use of agents produced by . We expect that these new studies will deepen our understanding of how genetics plays a role in the efficacy of pharmaceutical products for hypercholesterolemia, potentially leading to improved efficacy and safety of treatments for these common chronic diseases."

David Goldstein David Goldstein is a radio talk show host and blogger in Seattle, Washington. He hosts "The David Goldstein Show" on Saturdays and Sundays on 710 KIRO. Goldstein first gained notoriety in 2003 for Initiative 831, which would have officially proclaimed Washington State political , Ph.D., of Duke IGSP, said, "This collaboration provides Duke with powerful leads generated by Clinical Data to identify and evaluate gene variants that make a real difference to how to better treat patients with hypercholesterolemia. In addition, with Clinical Data's commercial footprint in this area, they make an ideal partner for us to advance genomics into medical practice. We are pleased to have reached this agreement in which patients and physicians, as well as both parties, have the potential for significant benefit."

Drew Fromkin, Executive Vice President of Clinical Data, said, "IGSP research will open up new commercialization opportunities derived both from our investment in STRENGTH and from the research expertise and strong scientific capabilities of the Duke University investigators. We are very excited about this opportunity, PGxHealth's role in advancing this research, and the relationship that has been established with Duke University and its leadership."

As previously announced, the Clinical Data STRENGTH studies involved evaluating the response of 679 patients to atorvastatin atorvastatin /ator·va·stat·in/ (ah-tor?vah-stat´in) an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used as the calcium salt in the treatment of hypercholesterolemia and other forms of dyslipidemia. , pravastatin pravastatin /prav·a·stat·in/ (prav´ah-stat?in) an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used as the sodium salt in the treatment of hypercholesterolemia and other forms of dyslipidemia and to lower the , simvastatin simvastatin /sim·va·stat·in/ (sim´vah-stat?in) an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used in the treatment of hypercholesterolemia and other forms of dyslipidemia and to lower the risks associated , lovastatin lovastatin /lo·va·stat·in/ (lo´vah-stat?in) an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used in the treatment of hypercholesterolemia and other forms of dyslipidemia and to lower the risks associated with  and cerivastatin cerivastatin Baycol® Cardiology Cholesterol-lowering, HMG-CoA reductase inhibitor/statin for managing hypercholesterolemia and mixed dyslipidemia; it ↑ HDL-C and ↓ LDL-C; withdrawn from the market as it was linked to rhabdomyolysis. See Statin. ; and genotyped approximately 175 genes. Approximately 700 additional patients were evaluated at baseline. Clinical Data researchers have completed SNP- and haplotype-based association analyses of response to statins as measured by changes in lipid parameters and for baseline variables.

About the Institute for Genome Sciences & Policy at Duke University

The Duke Institute for Genome Sciences & Policy conducts focused research in the areas of pharmacogenetics Pharmacogenetics Definition

Pharmacogenetics is the study of how the actions of and reactions to drugs vary with the patient's genes.
Description
, genomic medicine, population genomics, evolutionary genomics, genome technology, computational biology Not to be confused with Biologically-inspired computing.
Computational biology is an interdisciplinary field that applies the techniques of computer science, applied mathematics, and statistics to address problems inspired by biology.
, bioinformatics, genome ethics, law, and policy. Through interdisciplinary investigations, the IGSP uses genome sciences and policy together to understand and improve human health, life and experience. The IGSP partners with industry to develop and translate novel therapies and predictive biomarkers into clinical research and practice to optimize efficiency, effectiveness and success in bringing the right therapy to the right patient at the right time. For more information, go to www.genome.duke.edu.

About Clinical Data, Inc.

Clinical Data, Inc. is a worldwide leader in providing comprehensive molecular and pharmacogenomics services as well as genetic tests to improve patient care. The Company, founded in 1972, is organized under three worldwide divisions segmented by service offerings and varying client constituents: PGxHealth(TM); Cogenics(TM); and Vital Diagnostics(TM). Clinical Data's Therapeutic Diagnostics(TM) division, PGxHealth, builds upon existing assets and know-how acquired from Genaissance Pharmaceuticals in the areas of genomics-based, genetic tests and therapeutic efficacy and safety biomarker development for drug utilization. PGxHealth plans to develop and introduce novel Therapeutic Diagnostics in some instances in combination with new and existing therapeutics. Clinical Data's Pharmacogenomics and Molecular Services(TM) division, Cogenics, consolidates the operations of Genaissance Pharmaceuticals, Inc., Lark Technologies, Inc. and Icoria, Inc., each acquired during 2005, and Genome Express SA, acquired in 2006. Cogenics provides a comprehensive range of molecular and pharmacogenomics services to pharmaceutical, biotech, academia, agricultural, and government clients. These services are offered in both research and regulated environments and have applications across the lifecycle of pharmaceutical product development including pharmacovigilance requirements post-launch. Clinical Data's Vital Diagnostics division consolidates the operations of Clinical Data Sales & Service, Inc., Vital Scientific NV, Vital Diagnostics Pty. Ltd., and Electa Lab s.r.l. This division serves the clinical laboratory in the traditional in-vitro diagnostics market worldwide with a focus on the physician's office, hospital and small-to-medium sized laboratory segments. With customers in approximately 100 countries, Vital Diagnostics has achieved a leading market share for instruments and reagents sold into moderately complex physicians' office laboratories within the United States United States, officially United States of America, republic (2005 est. pop. 295,734,000), 3,539,227 sq mi (9,166,598 sq km), North America. The United States is the world's third largest country in population and the fourth largest country in area. . Clinical Data currently employs a staff of over 430. The Company is headquartered in Newton, Massachusetts The City of Newton in Middlesex County, Massachusetts, is an important residential suburb of Boston, which abuts it on the east. According to the 2000 census, the population of the Newton was 83,829, making it the tenth largest city in the state.  with operations in Texas, Connecticut, RTP (1) (Rapid Transport Protocol) The protocol used in IBM's High Performance Routing (HPR) system.

(2) (Realtime Transport Protocol) An IP protocol that supports real time transmission of voice and video.
 - North Carolina North Carolina, state in the SE United States. It is bordered by the Atlantic Ocean (E), South Carolina and Georgia (S), Tennessee (W), and Virginia (N). Facts and Figures


Area, 52,586 sq mi (136,198 sq km). Pop.
, Rhode Island Rhode Island, island, United States
Rhode Island, island, 15 mi (24 km) long and 5 mi (8 km) wide, S R.I., at the entrance to Narragansett Bay. It is the largest island in the state, with steep cliffs and excellent beaches.
, and California as well as internationally in the UK, France, the Netherlands, Italy and Australia. Furthermore, Clinical Data has numerous distribution, licensing, development and other collaborations with key partners.

SAFE HARBOR Safe Harbor

1. A legal provision to reduce or eliminate liability as long as good faith is demonstrated.

2. A form of shark repellent implemented by a target company acquiring a business that is so poorly regulated that the target itself is less attractive.
 STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM ACT The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  OF 1995

This press release contains certain forward-looking information and statements that are intended to be covered by the safe harbor for forward looking statements provided by the Private Securities Litigation Reform Act of 1995. Forward-looking statements are statements that are not historical facts. Words such as "expect(s)", "feel(s)", "believe(s)", "will", "may", "anticipate(s)" and similar expressions are intended to identify forward-looking statements. These statements include, but are not limited to, statements about our ability to successfully integrate the operations, business, technology and intellectual property obtained in our recent acquisitions; our ability to obtain regulatory approval for, and successfully introduce our new products; our ability to expand our long-term business opportunities; our ability to maintain normal terms with our customers and partners; financial projections and estimates and their underlying assumptions; and statements regarding future performance. Such statements are subject to certain risks and uncertainties, the effects of which are difficult to predict and generally beyond the control of the Company, that could cause actual results to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include, but are not limited to, whether Clinical Data will be able to develop or acquire additional products and attract new business and strategic partners; competition from pharmaceutical, biotechnology and diagnostics companies; the strength of our intellectual property rights; the effect on the Company's operations and results of significant acquisitions or divestitures made by major competitors; the Company's ability to achieve expected synergies and operating efficiencies in all of its acquisitions, and to successfully integrate its operations; and those risks discussed and identified by Clinical Data in its public filings with the U.S. Securities and Exchange Commission. Readers are cautioned not to place undue reliance on these forward-looking statements that speak only as of the date hereof. Clinical Data does not undertake any obligation to republish revised forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. Readers are also urged to carefully review and consider the various disclosures in Clinical Data's SEC reports, including but not limited to its Annual Report on Form 10-KSB for the fiscal year ended March 31, 2005, and fiscal 2005 and 2006 quarterly reports on Forms 10-QSB and 10-Q.
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Publication:Business Wire
Geographic Code:1USA
Date:May 12, 2006
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