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Clinical Data Launches PGxHEALTH(TM) and COGENICS(TM); PGxHEALTH Engaged in Discovery of Biomarkers and Introducing Therapeutic Diagnostics(TM).


NEWTON, Mass. -- COGENICS Provides a Broad Range of Pharmacogenomics and Molecular Services

VITAL DIAGNOSTICS Continues Focus and Performance in Traditional Diagnostics Market

Clinical Data, Inc. (NASDAQ NASDAQ
 in full National Association of Securities Dealers Automated Quotations

U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on
: CLDA CLDA California Lyme Disease Association ), a worldwide leader in providing comprehensive molecular and pharmacogenomics services as well as clinical diagnostics to improve patient care, announced today further refinement of its organizational structure This article has no lead section.

To comply with Wikipedia's lead section guidelines, one should be written.
. The company's business units now include three divisions: PGxHEALTH(TM), COGENICS(TM) and VITAL DIAGNOSTICS(TM).

Clinical Data continues to integrate its molecular and pharmacogenomics services, reflecting its completion and integration of a series of strategic acquisitions in 2005. The PGxHEALTH and COGENICS divisions collectively position Clinical Data among the largest, independent providers of pharmacogenomics and clinical diagnostics services in the world.

The Company is dedicated to using a variety of scientific methods (e.g. genotyping, sequencing, gene expression, bioinformatics, and metabolomics) to improve drug development, enhance patient outcomes and reduce the total cost of care. The following business structure furthers Clinical Data's commitment to its clients as highlighted in the Company's new tag line, "From Targeted Science to Better Healthcare(TM)."

--PGxHEALTH - Introducing Therapeutic Diagnostics(TM): PGxHEALTH builds upon existing assets acquired from Genaissance Pharmaceuticals in the areas of genomics-based, clinical diagnostics, therapeutic efficacy and safety biomarker development for drug utilization. The division has commenced a pivotal Phase III clinical trial Noun 1. phase III clinical trial - a large clinical trial of a treatment or drug that in phase I and phase II has been shown to be efficacious with tolerable side effects; after successful conclusion of these clinical trials it will receive formal approval from the  for Vilazodone, a novel compound being studied for treatment of depression, to be used in combination with a genomics based efficacy biomarker. The division is also responsible for the development of a safety biomarker for use with the anti-psychotic clozapine clozapine /clo·za·pine/ (klo´zah-pen) a sedative and antipsychotic agent; used in the treatment of schizophrenia.

clo·za·pine
n.
 and of genetic markers for cardiac channelopathies including Familial Long QT Syndrome The long QT syndrome (LQTS) is a heart condition associated with prolongation of repolarisation (recovery) following depolarisation (excitation) of the cardiac ventricles. It is associated with syncope (fainting) and sudden death due to ventricular arrhythmias.  (LQTS LQTS Long QT interval syndrome, see there ), Brugada Syndrome Brugada syndrome Cardiology A condition in which people with no known heart problems or defects suffer sudden cardiac death or aborted sudden cardiac death EKG Right bundle branch block, persistent ST-segment elevation in V1 to V3 unexplained by electrolyte , Short QT Syndrome Short QT syndrome is a genetic disease of the electrical system of the heart. It consists of a constellation of signs and symptoms, consisting of a short QT interval interval on EKG (≤ 300 ms) that doesn't significantly change with heart rate, tall and peaked T waves, and a  (STQS), and related syndromes.

PGxHEALTH utilizes its expertise and infrastructure to discover genetic markers that assist healthcare providers in determining the most efficacious and safe therapeutics for patients and, in some instances, an individual's propensity for a given disease. The company intends to develop and introduce novel Therapeutic Diagnostics(TM) in combination with new and existing therapeutics. Therapeutic Diagnostics (TM) are clinical diagnostics that utilize unique genetic markers or sets of genetic markers to determine which individuals will experience optimal benefit from specific therapies. Optimization of therapy for individuals will, in turn, result in the most desirable clinical outcomes for patients and their caregivers while also leading to reductions in the total cost of care for those who are paying for the care including but not limited to payors, employers and consumers.

Clinical Data is already developing and delivering clinical diagnostics based on its own intellectual property, in-licensing additional intellectual property and partnering with pharmaceutical, biotechnology, and academic institutions, all with the goal of marketing new clinical diagnostics with an emphasis on targeted therapies. Utilizing its HAP HAP. An old word which signifies to catch; as, "to hap the rent," to hap the deed poll." Techn. Dict. h.t. (TM) Database as a resource for biomarker and SNP SNP Scottish National Party

Noun 1. SNP - (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is altered; SNPs are usually considered to be point mutations that have been evolutionarily
 identification along with other available resources, PGxHEALTH has an advantage with respect to its own marker discovery efforts as well as for its initiatives with partners.

Today, PGxHEALTH has or is pursuing the development of tests in the CNS See Continuous net settlement.

CNS

See continuous net settlement (CNS).
, cardiovascular, and oncology fields.

--COGENICS - Comprehensive Pharmacogenomics and Molecular Services(TM): COGENICS' business and lab operations are represented by the combined operations, sales and marketing infrastructure of Genaissance Pharmaceuticals, Inc., Lark Technologies, Inc. and Icoria, Inc. The division provides a comprehensive range of in-house molecular and pharmacogenomics services to pharmaceutical, biotech, academia, agricultural, and government clients. These services are offered in both research and regulated environments. Furthermore, these services have applications across the lifecycle of pharmaceutical product development, including pharmacovigilance requirements post launch.

The division's service offerings include DNA DNA: see nucleic acid.
DNA
 or deoxyribonucleic acid

One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes.
 and RNA RNA: see nucleic acid.
RNA
 in full ribonucleic acid

One of the two main types of nucleic acid (the other being DNA), which functions in cellular protein synthesis in all living cells and replaces DNA as the carrier of genetic
 extraction; genotyping on a variety of platforms; sequencing; gene expression and pathway analysis; tissue laser dissection; and biorepository. In addition, the COGENICS division utilizes know-how and products from PGxHEALTH in support of clinical trials including development of protocols and informed consents for genetic testing Genetic Testing Definition

A genetic test examines the genetic information contained inside a person's cells, called DNA, to determine if that person has or will develop a certain disease or could pass a disease to his or her offspring.
 and genotype-phenotype association analysis for the discovery of biomarkers for COGENICS' clients. COGENICS also assists its clients in the application of pharmacogenetics Pharmacogenetics Definition

Pharmacogenetics is the study of how the actions of and reactions to drugs vary with the patient's genes.
Description
 in evaluation of the proarrhythimic or QT-prolonging potential of molecules in development, as recommended in the draft guideline ICHE ICHE Illinois Christian Home Educators (Russell, IL)
ICHE Infection Control and Hospital Epidemiology (journal)
ICHE International Conference on Higher Education
14, currently in Step 5 of implementation. (International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH See Intel Hub Architecture. ), http://www.ich.org/).

COGENICS currently runs and has in development numerous GLP-validated and research assays. These assays cover key SNPs relating to target identification, drug development activities and ultimately drug usage in specific populations and apply to both biologics and small molecules in all therapeutic areas. Along with its marketing focus, the COGENICS business unit has extensive experience working with the market leading platform providers including Affymetrix, Agilent, ABI Abi (ā`bī) [short for Abijah], in the Bible, King Hezekiah's mother.


(Application Binary Interface) A specification for a specific hardware platform combined with the operating system.
 and others for its sequencing, genotyping and gene expression services.

Additionally, Clinical Data has a group that will focus on metabolomic profiling that leverages its expertise and multi-platform technologies to address the growing need for mechanism-based biomarkers in drug development and medical care. This group has the capabilities to measure and interpret biochemical changes biochemical changes (bī·ō·keˈmik·  in cells, tissues and biofluids using mass spectrometry mass spectrometry
 or mass spectroscopy

Analytic technique by which chemical substances are identified by sorting gaseous ions by mass using electric and magnetic fields.
 and advanced informatics.

--VITAL DIAGNOSTICS - Making Diagnostics Accessible(TM): Vital Diagnostics is derived from the operations of Clinical Data Sales & Service, Inc., Vital Scientific NV, Vital Diagnostics Pty. Ltd., and Electa Lab s.r.l. This division is geared toward servicing the clinical laboratory in the traditional clinical in-vitro diagnostics (IVD (Interactive VideoDisc) See interactive video. ) market worldwide with a focus on the physician's office, hospital and small-to-medium sized laboratory segments. With customers in approximately 100 countries, VITAL DIAGNOSTICS has also achieved a leading market share for instruments and reagents sold into moderately complex physicians' office laboratories within the United States.

Drew Fromkin, Executive Vice President said, "Our decision to restructure Clinical Data's molecular services operations and create new branding for the organization reflects management's desire to better define the Company's distinct capabilities. This approach further enables the Company to develop focused offerings that meet the unique requirements of our diverse clientele. COGENICS is a strong, established business propelled by a comprehensive set of molecular and pharmacogenomics services, all of which are essential to aiding and improving drug development and related activities. PGxHEALTH is a new, growing and distinct business that employs advanced, molecular services and targeted science to discover novel efficacy and safety biomarkers. Our Company incorporates these findings into its Therapeutic Diagnostics with the intention of using these tests to optimize drug utilization in specific populations and achieve improved clinical outcomes, which ultimately reduces the total cost of care. We are all very excited about Clinical Data's current set of assets as a strong foundation for these two divisions and the opportunity to provide our clients and the healthcare industry with these valuable, innovative solutions."

SAFE HARBOR Safe Harbor

1. A legal provision to reduce or eliminate liability as long as good faith is demonstrated.

2. A form of shark repellent implemented by a target company acquiring a business that is so poorly regulated that the target itself is less attractive.
 STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM ACT The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  OF 1995

This press release contains certain forward-looking information and statements that are intended to be covered by the safe harbor for forward looking statements provided by the Private Securities Litigation Reform Act of 1995. Forward-looking statements are statements that are not historical facts. Words such as "expect(s)", "feel(s)", "believe(s)", "will", "may", "anticipate(s)" and similar expressions are intended to identify forward-looking statements. Such statements are subject to certain risks and uncertainties, the effects of which are difficult to predict and generally beyond the control of the Company, that could cause actual results to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include, but are not limited to, whether Vilazodone will advance further in the clinical trials process; whether future clinical trials will warrant continued product development; whether and when, if at all, Vilazodone will receive final approval from the U.S. Food and Drug Administration or equivalent regulatory agencies, and for which indications; the extent to which genetic markers (haplotypes) are predictive of clinical outcomes and drug efficacy and safety; whether Vilazodone will be successfully marketed; whether Clinical Data will be able to develop or acquire additional products and attract new business and strategic partners; competition from pharmaceutical, biotechnology and diagnostics companies; the strength of our intellectual property rights; the effect on the Company's operations and results of significant acquisitions or divestitures made by major competitors; the Company's ability to achieve expected synergies and operating efficiencies in all of its acquisitions, and to successfully integrate its operations; and those risks discussed and identified by Clinical Data in its public filings with the U.S. Securities and Exchange Commission. Readers are cautioned not to place undue reliance on these forward-looking statements that speak only as of the date hereof. Clinical Data does not undertake any obligation to republish revised forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. Readers are also urged to carefully review and consider the various disclosures in Clinical Data's SEC reports, including but not limited to its Annual Report on Form 10-KSB for the fiscal year ended March 31, 2005, and fiscal 2005 and 2006 quarterly reports on Forms 10-QSB and 10-Q.

Internet Website: www.clda.com
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Date:Mar 1, 2006
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