Chromatin Announces International Partnerships to Introduce Mini-Chromosomes into Canola.Business Editors/Health/Medical Writers BIOWIRE2K CHICAGO--(BUSINESS WIRE)--Jan. 21, 2004 Cibus Genetics, National Research Council of Canada's Plant Biotechnology Institute The Biotechnology Institute is an independent nonprofit organization founded to teach the public about the benefits of biotechnology. It was created in 1998 by the biotechnology industry and is located in Arlington, Virginia. to Show Viability of Custom-Made Chromosomes in Important Commercial Species Chromatin chromatin: see chromosome. Inc. announced today that it has entered into partnerships with the National Research Council Canada Plant Biotechnology Institute (NRC-PBI) and Cibus Genetics of San Diego, California “San Diego” redirects here. For other uses, see San Diego (disambiguation). San Diego is a coastal Southern California city located in the southwestern corner of the continental United States. As of 2006, the city has a population of 1,256,951. , to generate canola canola see brassicanapus. plants containing mini-chromosomes. The collaboration between Chromatin and Cibus and Chromatin and NRC-PBI are the first projects to introduce mini-chromosomes into a plant with significant commercial value. Canola and related crops are a $10 billion annual crop worldwide and are used for animal meal and for food oils and industrial oils, according to according to prep. 1. As stated or indicated by; on the authority of: according to historians. 2. In keeping with: according to instructions. 3. the Canola Council of Canada. Chromatin's proprietary mini-chromosome technology allows the simultaneous introduction of multiple genes into plants without disrupting the plant's own chromosomes. "Our technology is the first to produce plants with multi-gene cassettes that ensure stable and consistent gene expression," said Chromatin's CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. , Mich Hein. "While other technologies provide some of these attributes, the suite of opportunities promised by mini-chromosome technology is unrivaled." Alternatives to mini-chromosomes that are currently in use introduce one or a few genes randomly into a plant's chromosomes. Without mini-chromosomes, combining several genes together requires many years of plant breeding plant breeding, science of altering the genetic pattern of plants in order to increase their value. Increased crop yield is the primary aim of most plant-breeding programs; advantages of the hybrids and new varieties developed include adaptation to new agricultural , slowing the ability to introduce varieties with multiple desirable traits. In contrast, mini-chromosome technology enables "stacking" of genes to produce improved product quality and increased yield, as well as resistance to herbicides, insects and pathogens, in a single event that does not disrupt the plant's genome. As a result, mini-chromosomes could decrease time to market for engineered plants by 50 percent. "Mini-chromosome technology clearly addresses a number of important hurdles in the world of transgenics trans·gen·ics n. (used with a sing. or pl. verb) The study of or methodology used to create transgenic animals or plants. today," said Keith Walker, president of Cibus Genetics. "Ultimately I think mini-chromosomes could become the means of choice for adding traits to plants and could replace conventional transformation." Chromatin has entered into separate agreements with Cibus and NRC-PBI, though the two projects will mirror each other. Cibus and NRC-PBI, both recognized leaders in gene manipulation and cell culture and breeding systems, will regenerate re·gen·er·ate v. re·gen·er·at·ed, re·gen·er·at·ing, re·gen·er·ates v.tr. 1. To reform spiritually or morally. 2. To form, construct, or create anew, especially in an improved state. cells containing mini-chromosomes and develop them into mature plants. "NRC-PBI has a history of successful partnerships and collaborations. NRC-PBI's partnership with Chromatin will increase our scientific and technical capabilities in canola improvement and diversification," says Dr. Kutty Kartha, Director General of NRC-PBI. Chromatin's mini-chromosome technology was developed in the laboratory of the company's co-founder, Daphne Preuss, at the University of Chicago. Initially, the work with Cibus and NRC-PBI will demonstrate the viability of mini-chromosomes and will involve placing visible markers to detect and evaluate the chromosomes. However, subsequent experiments will involve the introduction of genes with commercial value, such as resistance to widely used herbicides. "This project demonstrates mini-chromosomes moving from the technical proof of principle phase and into commercial proof of principle," said Hein. "The partnerships allow all three organizations to leverage their technical expertise to find the most promising path moving a product concept to market." Results from the first phase of the collaboration between Chromatin, PBI PBI protein-bound iodine. PBI abbr. protein-bound iodine PBI, n See iodine, protein-bound. PBI protein-bound iodine. and Cibus are expected toward the end of first quarter of 2004. About NRC-PBI Recognized globally for research and innovation, Canada's National Research Council (NRC NRC abbr. 1. National Research Council 2. Nuclear Regulatory Commission Noun 1. NRC - an independent federal agency created in 1974 to license and regulate nuclear power plants ) is a leader in the development of an innovative, knowledge-based economy for Canada through science and technology. As part of the NRC, the NRC Plant Biotechnology Institute (NRC-PBI) conducts collaborative plant biotechnology research with universities, government agencies and industry, helping to transfer research to product development and commercialization. For more information go to: http://www.pbi-ibp.nrc-cnrc.gc.ca About Cibus Genetics Cibus Genetics is focused on developing innovative products in agriculture and specialty chemicals utilizing Genoplasty, a proprietary gene repair technology. Genoplasty is a unique site-specific mutagenesis mutagenesis /mu·ta·gen·e·sis/ (mu?tah-jen´e-sis) 1. the production of change. 2. the induction of genetic mutation. mu·ta·gen·e·sis n. pl. technology that allows precise changes to be inserted into target genes which may be used to introduce genetic improvements without the need for foreign DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. . In addition, the company has developed in-depth expertise in various crops in the area of in vitro in vitro /in vi·tro/ (in ve´tro) [L.] within a glass; observable in a test tube; in an artificial environment. in vi·tro adj. In an artificial environment outside a living organism. cell culture and regeneration. For further information contact the company at info@cibusgenetics.com. About Chromatin Chromatin, Inc., develops and markets novel proprietary technology that enables entire chromosomes to be designed and incorporated into plant cells. These engineered chromosomes make it possible for the first time to simultaneously introduce multiple genes into a plant cell while maintaining precise control of gene expression. Chromatin is employing these new genetic tools to design and market products that confer commercially valuable traits in plants, including improved nutritional and health characteristics, and can be used for industrial, agricultural and pharmaceutical product development. For more information go to www.chromatininc.com. |
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