Cholecystokinin and Its Antagonists in Pain Management.9780789028921 Cholecystokinin cholecystokinin /cho·le·cys·to·ki·nin/ (CCK) (-ki´nin) a polypeptide hormone secreted in the small intestine that stimulates gallbladder contraction and secretion of pancreatic enzymes. and its antagonists in pain management. McCleane, Gary. Haworth Medical Press 2006 145 pages $19.95 Paperback Haworth series in clinical pain and symptom palliation pal·li·ate tr.v. pal·li·at·ed, pal·li·at·ing, pal·li·ates 1. To make (an offense or crime) seem less serious; extenuate. 2. QP572 Cholecystokinin (CCK (Complimentary Code Keying) A direct sequence spread spectrum (DSSS) coding method used in the 802.11b wireless LAN standard for 5.5 and 11 Mbps. The slower 1 and 2 Mbps specifications use Barker coding which has a chip rate of 11 compared to 8 in CCK. ) is the regulatory peptide hormone Peptide hormones are a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. Like other proteins, peptide hormones are synthesized from amino acids according to an mRNA template, which is itself synthesized from a DNA found primarily in the gastro-intestinal tract that works as a neurotransmitter neurotransmitter, chemical that transmits information across the junction (synapse) that separates one nerve cell (neuron) from another nerve cell or a muscle. Neurotransmitters are stored in the nerve cell's bulbous end (axon). throughout the nervous system. Consultant and physician McCleane examines here the benefits of CCK antagonists working with opioids as a pain control therapy, starting by describing the role of opioids alone, the characteristics of CCK and its function as a "gut peptide,", its use as a central nervous system peptide, central effects of CCK, factors that increase central CCK representation, CCK as an antiopioid peptide, CCK receptor antagonists and whether they influence opioid-derived antiniciception, whether CCK antagonists reduce tolerance to some of the effects of opioids, whether the CCK-opioid combination is safe, the results of human studies, and other potential uses, as in biliary colic, pancreatitis and anxiolysis. ([c]20062005 Book News, Inc., Portland, OR) |
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