Chiroscience & Bristol-Myers Squibb in Cancer Collaboration.PRINCETON, N.J. and CAMBRIDGE, England--(BUSINESS WIRE)-- February 11, 1998-- BMS BMS abbr. Bachelor of Marine Science Licenses Two Innovative New Cancer Drugs Chiroscience Group plc (London Stock Exchange London Stock Exchange London marketplace for securities. It was formed in 1773 by a group of stockbrokers who had been doing business informally in local coffeehouses. : CRO.) and Bristol-Myers Squibb Bristol-Myers Squibb (NYSE: BMY), colloquially referred to as BMS, is a pharmaceutical corporation, formed by a 1989 merger between pharmaceutical companies Bristol-Myers Company, founded in 1887 by William McLaren Bristol and John Ripley Myers in Clinton, NY (both were Company (NYSE NYSE See: New York Stock Exchange :BMY BMY Bristol Myers Squibb ) today announce research and licensing agreements in the area of matrix metalloproteinase (MMP MMP Matrix Metalloproteinase (enzymes related to tissue healing/remodeling and cancer cell metastasis) MMP Mixed Member Proportional (New Zealand electoral system) MMP Multi-man Publishing ) inhibitors for the treatment of cancer. Bristol-Myers Squibb will license Chiroscience's MMP program, including the worldwide rights to two lead compounds designated D2163 and D1927. In addition, both companies have entered a three-year oncology research collaboration to discover new selective MMP inhibitors. Financial terms were not disclosed. According to according to prep. 1. As stated or indicated by; on the authority of: according to historians. 2. In keeping with: according to instructions. 3. the terms of the agreements, Chiroscience will receive development milestones for all products, as well as royalties on sales. In addition, Bristol-Myers Squibb will pay undisclosed access and research fees and will gain all rights to new and jointly selected MMP inhibitors that are developed for oncology; Chiroscience will retain the rights for MMP inhibitors in all other therapeutic areas. Matrix metalloproteinases are a family of enzymes over-expressed in tumor tissues and have been found to support the growth, invasion, and metastatic Metastatic The term used to describe a secondary cancer, or one that has spread from one area of the body to another. Mentioned in: Coagulation Disorders metastatic pertaining to or of the nature of a metastasis. process of developing tumors. D2163 and D1927 are potent oral inhibitors of these enzymes. D2163 entered Phase I clinical trials in England in December. D1927 is expected to enter Phase I clinical trials in March. It is expected that these second-generation MMP inhibitors will have an improved safety profile in humans, due to their selectivity, compared to other MMP inhibitors in development. This approach may also produce improvements in efficacy. The research collaboration between Chiroscience and Bristol-Myers Squibb will focus on understanding the role of MMPs in different tumors in order to develop additional MMP inhibitors with different selectivity profiles. Chiroscience's proprietary gene expression technology will be utilized to study enzyme profiles in human tumors. Said Dr. John Padfield, Chief Executive Officer of Chiroscience: "We are delighted to have licensed D2163 and D1927 to Bristol-Myers Squibb, the world's leading oncology company, and to have entered into a collaboration to discover new MMP inhibitors. These agreements validate our MMP program and provide real hope for more effective and well-tolerated treatments for many types of cancer. The agreements also recognize the leading position held by Chiroscience in its gene expression capabilities, as the proprietary genetic analysis technologies developed at our site in Seattle will be a major part of the research collaboration." "We are committed to the discovery and development of innovative treatments for cancer," said Dr. Peter S. Ringrose, President, Bristol-Myers Squibb Pharmaceutical Research Institute. "These agreements with Chiroscience underscore our strategic interest in the area of MMP inhibition and provide us with the opportunity to develop the novel drug candidates D2163 and D1927 as well as take a lead in understanding physiological mechanisms promoting the progression of cancer and the role of MMPs in this process." Notes: Chiroscience Group plc Chiroscience Group plc is an emerging pharmaceutical company, which uses its diverse technology platform to discover and develop novel medicines for improved healthcare. The Group has two principal activities, operating as Darwin Discovery and ChiroTech. Chiroscience is listed on the London Stock Exchange. Darwin Discovery embraces activities in Cambridge and Stevenage, England, and Seattle, Washington, including gene-based research and molecular biology molecular biology, scientific study of the molecular basis of life processes, including cellular respiration, excretion, and reproduction. The term molecular biology was coined in 1938 by Warren Weaver, then director of the natural sciences program at the Rockefeller , through chiral-based, combinatorial, medicinal, and process chemistries, to clinical development. It is engaged in the discovery and development of innovative small molecule drugs and related diagnostics with a therapeutic focus on autoimmune disease autoimmune disease, any of a number of abnormal conditions caused when the body produces antibodies to its own substances. In rheumatoid arthritis, a group of antibody molecules called collectively RF, or rheumatoid factor, is complexed to the individual's own gamma , cancer, inflammation, pain, and osteoporosis. ChiroTech provides chiral chi·ral adj. Of or relating to the structural characteristic of a molecule that makes it impossible to superimpose it on its mirror image. chi·ral technology services to customers within the pharmaceutical and related industries in support of Darwin Discovery's research and development programs. Bristol-Myers Squibb Bristol-Myers Squibb is a diversified worldwide health and personal care company whose principal businesses are pharmaceuticals, consumer products, nutritionals, and medical devices. It is a leading maker of innovative therapies for cardiovascular, metabolic and infectious diseases, central nervous system and dermatological disorders, and cancer. The company is a leader in consumer medicines, orthopedic devices, ostomy ostomy Surgical opening in the body, or the operation creating it, usually to allow discharge of wastes through the abdominal wall. It may be temporary, to relieve strain on damaged organs, or permanent, to replace normal channels congenitally missing or surgically removed care, wound management, nutritional supplements Nutritional Supplements Definition Nutritional supplements include vitamins, minerals, herbs, meal supplements, sports nutrition products, natural food supplements, and other related products used to boost the nutritional content of the diet. , infant formulas, and hair and skin care products. Visit Bristol-Myers Squibb on the World Wide Web at: http://www.bms.com CONTACT: Dr. Andy Richards, Director of Business Development Christine Soden, Finance Director Tel: +44 (0)171 831 3113 (February 11, 1998) Tel: +44 (0)1223 420430 (thereafeter) or Financial Dynamics Giles Sanderson Tel: +44 (0)171 831 3113 or Sciens Worldwide Julie McQuain Tel: (212) 477-0472 |
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