Chirality in drug research.9783527310760 Chirality chirality (kī·ralˑ·i·tē), n the “handedness” property of organic compounds (containing an asymmetrical carbon) that gives rise to structures that in drug research. Ed. by Eric Francotte and Wolfgang Lindner. Wiley-VCH 2006 351 pages $175.00 Hardcover Methods and principles in medicinal chemistry RS429 A growing number of pharmaceutical drugs are chiral chi·ral adj. Of or relating to the structural characteristic of a molecule that makes it impossible to superimpose it on its mirror image. chi·ral (referring to a molecules that are non-superimposable upon their mirror-images) because of their unique pharmacological properties. Following a history of chirality in drugs, Francotte (director and head of separations, Novartis Institutes for BioMedical Research, Switzerland) and Lindner (analytical chemistry, U. of Vienna, Austria) present three chapters discussing synthesis of chiral drugs. An industrial perspective is given on the stereoselective synthesis of drugs, aspects of chirality in natural products drug discovery are examined, and biotransformation biotransformation /bio·trans·for·ma·tion/ (-trans?for-ma´shun) the series of chemical alterations of a compound (e.g., a drug) occurring within the body, as by enzymatic activity. methods for preparing chiral drugs and drug intermediates are presented. The next five chapters discuss separations, offering treatments of resolution of chiral drugs and drug intermediates by crystallization Crystallization The formation of a solid from a solution, melt, vapor, or a different solid phase. Crystallization from solution is an important industrial operation because of the large number of materials marketed as crystalline particles. , isolation and production of optically pure drugs by enantioselective (able to select one of a chiral pair) chromatography, stereoselective chromatographic chro·mat·o·graph n. An instrument that produces a chromatogram. tr.v. chro·mat·o·graphed, chro·mat·o·graph·ing, chro·mat·o·graphs To separate and analyze by chromatography. methods for drug analysis, capillary electrophoresis coupled to mass spectrometry mass spectrometry or mass spectroscopy Analytic technique by which chemical substances are identified by sorting gaseous ions by mass using electric and magnetic fields. for chiral drugs analysis, and chiral molecular tools for preparation of enantiopure alcohols and simultaneous determination of their absolute configurations by x-ray crystallography or anisotrophy methods. The final chapter reviews software and literature research on chirality in modeling, chirality in docking, and chiral ligand-receptor interaction and symmetry. ([c]20072005 Book News, Inc., Portland, OR) |
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