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Chemicon International, Inc. Expands its Exclusive Agreement for Patented Compounds and Methods for Embryonic Stem - ES - Cell Research.


ATLANTA & MELBOURNE, Australia -- Serologicals Corporation (NASDAQ NASDAQ
 in full National Association of Securities Dealers Automated Quotations

U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on
: SERO SERO Southeast Regional Office
SERO Sekundaerrohstoffe (recycling, former GDR)
SERO Syringe Exchange Resources Online
SERO System Engineering/Engineer Release Order
SERO Site Emergency Response Organisation (nuclear) 
) announced today that Chemicon International, Inc., its wholly-owned subsidiary based in Temecula, CA, has expanded its exclusive worldwide agreement with Amrad Corporation Ltd (ASX ASX

See: Australian Stock Exchange
: AML AML - A Manufacturing Language , Melbourne, Australia) and The Walter and Eliza Hall Institute of Medical Research Coordinates:

The Walter and Eliza Hall Institute of Medical Research is one of Australia's foremost medical research institutes.
 (WEHI WEHI Walter and Eliza Hall Institute of Medical Research (Melbourne, Australia) , Melbourne, Australia). The new agreement provides Chemicon additional rights to further develop its proprietary embryonic stem cell Embryonic stem cells (ES cells) are stem cells derived from the inner cell mass of an early stage embryo known as a blastocyst. Human embryos reach the blastocyst stage 4-5 days post fertilization, at which time they consist of 50-150 cells.

ES cells are pluripotent.
 products, Leukemia Inhibitory Factor Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a chemical in cells that affects their growth and development. Function
LIF derives its name from its ability to induce the terminal differentiation of myeloid leukaemic cells.
 (LIF 1. (hardware) LIF - Low Insertion Force.
2. (file format) LIF - Logical Interchange Format.
) and ESGRO(R) into additional kits and combination products. This new agreement provides an important expansion of the initial license agreement covering LIF patent rights signed by Chemicon, Amrad and WEHI in 1999 to include additional fields of use in non-therapeutic fields.

The new license affirms Chemicon's exclusive rights to develop, manufacture, sublicense and distribute LIF and LIF based products in the research market worldwide and expands the company's ability to develop, manufacture and commercialize diagnostic products. The new exclusive license also gives Chemicon access to patents and applications that cover LIF production and uses in various biotechnology applications. Through this agreement, Chemicon expands its rights to access Amrad's LIF and embryonic stem cell intellectual property portfolio, which now totals 45 granted and 7 pending patents for both LIF and ESGRO(R) applications. Amrad has retained all other rights under the LIF patents and patent applications for therapeutic applications and associated research activities.

Chemicon is the exclusive manufacturer of recombinant murine murine /mu·rine/ (mur´en) pertaining to, derived from, or characteristic of mice or rats.

mu·rine
adj.
 and human LIF and LIF based stem cell culture supplements, such as ESGRO(R) for diagnostic and research applications. LIF products are widely used as tools for the in vitro development, maintenance, and expansion of different stem cell types, including embryonic, neural, and hematopoietic stem cells. Long-term maintenance of mouse and, in many cases, human embryonic stem cells requires specialized media containing recombinant LIF or ESGRO(R).

"We are pleased to have entered into this new agreement, which will allow us to introduce new, high-profile LIF based products for the stem cell research community," said Jeffrey D. Linton, President of Chemicon International. "The new license is an extension of our strong and successful long-term collaboration with Amrad and WEHI in the development, manufacture and commercialization of recombinant LIF and its improved formulations in non-therapeutic fields."

"This agreement is further testament to Amrad's continued strategy of focusing on its core capabilities associated with developing therapeutic products that modulate cytokine Cytokine

Any of a group of soluble proteins that are released by a cell to send messages which are delivered to the same cell (autocrine), an adjacent cell (paracrine), or a distant cell (endocrine).
 activity, and out-licensing non-core technologies to partners with the greatest ability to realize their maximum potential. Along with our academic colleagues at the WEHI, where LIF was first discovered, we are delighted to have expanded our agreement with Chemicon on LIF," said Dr. Pete Smith, CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  of Amrad Corporation.

Chemicon International, Inc. offers a broad range of research products, including specialty reagents, kits, antibodies, and custom products and services, to customers working in the areas of neuroscience, stem cell biology, cancer, and infectious disease research. It is also a leading supplier of monoclonal antibodies, conjugates, antibody blends and molecular-based detection kits for use in diagnostic laboratories. Chemicon focuses on basic and biomedical research, drug discovery, and diagnostics, allowing it to serve thousands of customers worldwide in the academic, clinical, biotechnology, and pharmaceutical sectors. Acquired in 2003, Chemicon is a Serologicals company, based in Temecula, CA.

For more information, please visit our website: www.chemicon.com.

Amrad (ASX: AML) is a drug discovery and development biotechnology company based in Melbourne, Australia. Amrad's core business is discovering and commercializing therapeutic drugs that modulate the activity of cytokines Cytokines
Chemicals made by the cells that act on other cells to stimulate or inhibit their function. Cytokines that stimulate growth are called "growth factors.
, with a strong focus on therapeutic antibodies. Amrad's current R&D portfolio includes projects in the therapeutic areas of cancer, asthma and rheumatoid arthritis.

More information can be found at www.amrad.com.au.

Serologicals Corporation (NASDAQ: SERO), headquartered in Atlanta, GA., is a global leader in developing and commercializing consumable biological products, enabling technologies and services in support of biological research, drug discovery, and the bioprocessing of life-enhancing products. Our customers include researchers at major life science companies and leading research institutions involved in key disciplines, such as neurology, oncology, hematology, immunology, cardiology, proteomics, infectious diseases, cell signaling and stem cell research. In addition, Serologicals is the world's leading provider of monoclonal antibodies for the blood typing industry.

Serologicals employs a total of more than 1,000 people worldwide in three Serologicals' companies: Chemicon International, headquartered in Temecula, CA, Upstate Group, LLC (Logical Link Control) See "LANs" under data link protocol.

LLC - Logical Link Control
, headquartered in Charlottesville, VA. and Celliance Corporation, headquartered in Atlanta, GA.

For more information, please visit our website: www.serologicals.com.

This release contains certain forward-looking statements within the meaning of the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  of 1995. Words or phrases such as "should result," "are expected to," "we anticipate," "we estimate," "we project" and similar expressions are intended to identify forward-looking statements. These statements are subject to certain risks and uncertainties that could cause actual results to differ materially from those expressed in any forward-looking statements. The risks and uncertainties include, among other things, Chemicon's ability to introduce new LIF-based products. You should not place undue reliance on forward-looking statements, since the statements speak only as of the date that they are made, and Serologicals undertakes no obligation to update these statements based on events that may occur after the date of this press release.

Serologicals is a registered trademark of Serologicals Royalty Company.
COPYRIGHT 2005 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2005, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Geographic Code:1USA
Date:Apr 5, 2005
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