Charles River Proteomics Adopt Nonlinear Dynamics' Progenesis Discovery Informatics.

NEWCASTLE UPON TYNE, England, and WORCESTER, Mass. -- Nonlinear Dynamics, a leading provider of bioinformatics solutions, today announced that Charles River Proteomics Services, Inc., (CRPS) has adopted Nonlinear's Progenesis Discovery Informatics platform to support the gel-based component of its proteomic service offering.

Building on the well-established Progenesis range, Progenesis Discovery Informatics is the leading edge proteomics solution for automated high-throughput gel analysis, data mining and support of lab based research. The informatics module provides additional functionality to store, link and track huge quantities of gel-based proteomic data. It has a range of statistical features which generate complex expression and standard queries via a simple interface. Enhanced processing features identify statistically significant changes in protein expression derived from multiple experiments.

Dr. James Jersey, President of CRPS, said, "Our goal is to help clients improve and accelerate their drug discovery and development processes through a greater understanding of biology at the protein level. It is essential in our 2DE efforts for CRPS to have tools that provide ease of use, automation, excellent data visualization, accuracy, and, statistically objective based measures of differential expression requiring minimal intervention."

Dr. John Pirro, General Manager of CRPS, adds further, "Due to the high throughput of our 2DE services, CRPS and our clients require the most comprehensive solution with the flexibility to accommodate large sample sets across projects. Progenesis Discovery Informatics provides this complete solution."

John Spreadbury, Group Sales and Marketing Director of Nonlinear Dynamics, and CEO of Nonlinear USA Inc., said "CRPS has an excellent professional standing in the proteomics marketplace, and we are delighted they have chosen to adopt Progenesis Discovery Informatics. Nonlinear is committed to developing solutions that lead the market in terms of throughput, accuracy and reproducibility. We believe Progenesis Discovery Informatics delivers the complete protein informatics solution that gives service providers and their clients a positive edge in the quality and consistency of gel-based research."

About Nonlinear Dynamics Ltd

Established in 1989, Nonlinear Dynamics is a leading worldwide provider of bioinformatics solutions to the life science industry. The Company's innovative product portfolio comprises high-quality analysis and data mining tools for 1D and 2D electrophoresis gels and microarrays, the core technologies of genomics and proteomics. Nonlinear sells and supports its products through its UK headquarters, its USA office, and its global network of partners and OEM resellers.

About Charles River Proteomic Services, Inc.:

Charles River Proteomic Services (CRPS), a joint venture between Charles River Laboratories, Inc. and Proteome Systems Ltd., provides high-throughput contract proteomic research services to the biotech, pharmaceutical and diagnostic industries. Employing a variety of proven technologies in combination with a fully integrated and web-enabled informatic LIMS system, CRPS provides an unrivalled outsourcing transparency and greatly enhanced levels of both scientific and budgetary control to its sponsors. All services are strictly confidential, on a fee-for-service basis with no attached royalty or intellectual property agreements. CRPS aim to assist clients in discovering and developing drugs with greater speed, specificity, potency and more favourable side effect profiles through a better understanding of protein expression and function.

About Charles River Laboratories, Inc.:

Charles River Laboratories, based in Wilmington, Massachusetts, is a leading provider of critical research tools and integrated support services that enable innovative and efficient drug discovery and development. The Company is the global leader in providing the animal research models required in research and development for new drugs, devices and therapies. The Company also offers a broad and growing portfolio of biomedical products and contract services that enable customers to accelerate, increase and enhance the productivity and effectiveness of their drug discovery and development efforts. Charles River's customer base spans over 50 countries, and includes all of the major pharmaceutical and biotechnology companies, and leading hospital, academic and government institutions. The Company operates 82 facilities in 16 countries worldwide.