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Charles River Laboratories Names Scientific Advisory Board; Board of Scientists Will Strengthen Scientific and Technology Opportunities for Company.


Business Editors/Health/Medical Writers

BIOWIRE2K

WILMINGTON, Mass.--(BUSINESS WIRE)--Nov. 13, 2003

Charles River Laboratories (NYSE NYSE

See: New York Stock Exchange
:CRL CRL - Carnegie Representation Language.

Carnegie Group, Inc. Frame language derived from SRL. Written in Common LISP. Used in the product Knowledge Craft.
), a leading provider of pre-clinical research products and services to pharmaceutical and biotechnology companies, announces the formation of its Scientific Advisory Board. The mission of this six member board is to provide advice, counsel and input with regard to potential new areas of growth to further enhance the Company's portfolio of high-end products and services. The appointments are: Geoffrey M. Duyk, M.D., Ph.D., of Exelixis Pharmaceuticals, Inc.; Joseph J. Catino, Ph.D., of Bayer Corporation; William S. Hancock, Ph.D., D.Sc., of the Barnett Institute at Northeastern University; Brian Huber, Ph.D., of GlaxoSmithKline; Colin McKerlie, D.V.M., D.V.Sc., M.R.C.V.S., of The Hospital for Sick Children; and, Jill Mesirov, Ph.D., of the Whitehead Institute.

James C. Foster James Clifford Foster is the chairman and chief executive officer of Charles River Laboratories, Inc., an international company that works on the drug discovery and development process. , Chairman, President and Chief Executive Officer of Charles River, said, "We are very excited to have these world class experts on our Scientific Advisory Board to help guide Charles River's success. They will play a vital role in advising us on technologies we currently use and new technologies for licensing, as well as advising us on potential acquisitions. Their technical expertise and scientific judgment will provide valuable insights, benefiting our customers in the pharmaceutical and biotech industries, academia, and government."

Chairman

Geoffrey M. Duyk, M.D., Ph.D.

President, Research and Development and Chief Scientific Officer

Director, Board of Directors

Exelixis Pharmaceuticals, Inc.

Dr. Duyk leads a 550+ person group focused on the discovery and development of small molecule therapeutics. Prior to joining Exelixis in 1977, he was Vice President of Genomics at Millennium where he was responsible for building and leading the informatics, automation, DNA sequencing and genotyping groups as well as the mouse and human genetics Human genetics

A discipline concerned with genetically determined resemblances and differences among human beings. Technological advances in the visualization of human chromosomes have shown that abnormalities of chromosome number or structure are surprisingly
 group. Prior to his tenure at Millennium, Dr. Duyk was an Assistant Professor at Harvard Medical School Harvard Medical School (HMS) is one of the graduate schools of Harvard University. It is a prestigious American medical school located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts.  while also serving as a Co- Principal Investigator at the National Institutes of Health. Dr. Duyk continues to be a member of numerous NIH "Not invented here." See digispeak.

NIH - The United States National Institutes of Health.
 panels and oversight committees focused on the planning and execution of the human genome project.

Members

Joseph J. Catino, Ph.D.

Senior Vice President, Research, Bayer Corporation

With 23 years of pharmaceutical experience, Dr. Catino has particular expertise in biotechnology, gene therapy and small molecule drug discovery. Under his leadership, eight pre-clinical candidates for the treatment of oncology and metabolic diseases have been delivered from the Bayer Research Center. Dr. Catino was involved in the highly successful collaboration between Bayer Corporation and Millennium Pharmaceuticals in the pursuit of genomic targets. Dr. Catino is also on the Board of Directors and Executive Committee of CURE, Connecticut United Research Excellence.

William S. Hancock, Ph.D., D.Sc.

Bradstreet Chair in Bioanalytical Chemistry

Barnett Institute and Department of Chemistry

Northeastern University

Dr. Hancock served on the faculty of Chemistry and Biochemistry of Massey University, New Zealand New Zealand (zē`lənd), island country (2005 est. pop. 4,035,000), 104,454 sq mi (270,534 sq km), in the S Pacific Ocean, over 1,000 mi (1,600 km) SE of Australia. The capital is Wellington; the largest city and leading port is Auckland. . After coming to the U.S., he was a visiting scientist at the Bureau of Drugs, Food and Drug Administration, in Washington D.C., then Director of Analytical Chemistry at Genentech, Inc., and Principal Laboratory Scientist at Hewlett-Packard Laboratories before joining ThemoFinnigan in 2000. He is an Adjunct Professor in the Department of Chemical Engineering of Yale, University. Dr. Hancock is the President of the California Separation Science Council. He has published over 160 articles, 34 review chapters, 7 books and holds 9 patents. He has recently agreed to be the senior editor of the new American Chemical Society's publication, Journal of Proteome pro·te·ome
n.
The complete set of proteins that are produced by the genes of an organism.



proteome

the entire complement of proteins produced by a cell.
 Research.

Brian Huber, Ph.D.

Vice President of the Biology Division, Drug Discovery

GlaxoSmithKline

Dr. Huber's current responsibilities include efforts in virology virology, study of viruses and their role in disease. Many viruses, such as animal RNA viruses and viruses that infect bacteria, or bacteriophages, have become useful laboratory tools in genetic studies and in work on the cellular metabolic control of gene expression  with interest in HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States. , Hepatitis C Hepatitis C Definition

Hepatitis C is a form of liver inflammation that causes primarily a long-lasting (chronic) disease. Acute (newly developed) hepatitis C is rarely observed as the early disease is generally quite mild.
, HPV HPV human papillomavirus.

HPV
abbr.
human papilloma virus


Human papilloma virus (HPV) 
, Herpes; metabolic disease, in particular, diabetes, obesity, aging, and molecular pharmacology. Dr. Huber is a member of numerous scientific and scholarly societies such as the American Association for Cancer Research Wikipedia is not the place for advertisement or self-advertising.

The American Association for Cancer Research (AACR) is an organization based in Philadelphia, Pennsylvania, that focuses on all aspects of cancer research including basic, clinical and translational
 and the American Society for Pharmacology and Experimental Therapeutics. He is also a Fellow of the American College of Clinical Pharmacology and a Diplomate dip·lo·mate
n.
One who has received a diploma, especially a physician certified as a specialist by a board of examiners.


diplomate
(dip´l
 of the American Board of Clinical Pharmacology.

Colin McKerlie, D.V.M., D.V.Sc., M.R.C.V.S.

Research Scientist, Integrative Biology Research Program

The Hospital for Sick Children

Toronto, Canada

Dr. McKerlie's research endeavors encompass the pathology phenotype of knock-out, transgenic, and mutagenized animals; rodent models of genetic and infectious lung disease; and, comparative pathology. He is Vice President of the Toronto Centre for Phenogenomics, one of the largest research centers for mouse models of human disease. Dr. McKerlie is also associated with the Samuel Lunenfeld Research Institute The Samuel Lunenfeld Research Institute of Mount Sinai Hospital (Toronto), Ontario, Canada was established in 1985 by an endowment from the Lunenfeld and Kunin families. It comprises 31 principal investigators, has a budget of C$90 million (2005/6), has 225 trainees and over 550 , one of the world's leading academic centers in biomedical research, particularly in functional genomics and the development of genomic tools including a priority program that focuses on transgenic mouse and embryonic stem cell Embryonic stem cells (ES cells) are stem cells derived from the inner cell mass of an early stage embryo known as a blastocyst. Human embryos reach the blastocyst stage 4-5 days post fertilization, at which time they consist of 50-150 cells.

ES cells are pluripotent.
 technologies to generate animal models of human disease.

Jill P. Mesirov, Ph.D.

Associate Director and Chief Informatics Officer

Director, Bioinformatics and Computational Biology Program

Whitehead Institute for Biomedical Research

Whitehead/MIT Center for Genome Research

In her current role, Dr. Mesirov is one of the leading contributors to the Human Genome Project. She is responsible for the bioinformatics, computational biology, and research computing program for the Center. She is also adjunct professor of bioinformatics at Boston University. Dr. Mesirov has spent many years working in high-performance computing and the development of parallel algorithms relevant to problems that arise in science, engineering and business applications. Among her many honors, Dr. Mesirov is a fellow of the American Association for the Advancement of Science American Association for the Advancement of Science (AAAS), private organization devoted to furthering the work of scientists and improving the effectiveness of science in the promotion of human welfare. . She also serves as an editor for several leading journals in computational science and applied mathematics.

About Charles River Laboratories

Founded nearly sixty years ago, Charles River Laboratories, based in Wilmington, Massachusetts, is a leading provider of critical research tools and integrated support services that enable innovative and efficient drug discovery and development. The Company is the global leader in providing the animal research models required in research and development for new drugs, devices and therapies. The Company also offers a broad and growing portfolio of biomedical bi·o·med·i·cal
adj.
1. Of or relating to biomedicine.

2. Of, relating to, or involving biological, medical, and physical sciences.
 products and services that enable customers to reduce cost, increase speed, and enhance productivity and effectiveness in drug discovery and development. Charles River's customer base spans over 50 countries, and includes all of the major pharmaceutical companies, biotechnology companies, and many leading hospitals and academic institutions. The Company operates 82 facilities in 16 countries worldwide.

Find out more about Charles River Laboratories at: www.criver.com
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Date:Nov 13, 2003
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