Charles River Laboratories Implements BioTrove High-Throughput SNP Genotyping System.WILMINGTON, Mass. -- Charles River Laboratories International, Inc. (NYSE NYSE See: New York Stock Exchange : CRL CRL - Carnegie Representation Language. Carnegie Group, Inc. Frame language derived from SRL. Written in Common LISP. Used in the product Knowledge Craft. ), a premier global provider of solutions that advance the drug discovery and development process, announces that it has adopted the OpenArray(TM) SNP SNP Scottish National Party Noun 1. SNP - (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is altered; SNPs are usually considered to be point mutations that have been evolutionarily Genotyping System from BioTrove. The BioTrove OpenArray platform will be used in Charles River's rigorous genetic quality control process. Using this high-throughput genotyping platform, Charles River will be able to rapidly analyze thousands of samples for SNP analysis per month, ensuring researchers the congenicity of their inbred in·bred adj. 1. Produced by inbreeding. 2. Fixed in the character or disposition as if inherited; deep-seated. inbred said of offspring produced by inbreeding. and first generation hybrid strains used in biomedical bi·o·med·i·cal adj. 1. Of or relating to biomedicine. 2. Of, relating to, or involving biological, medical, and physical sciences. studies. The OpenArray platform produces thousands of parallel PCR PCR polymerase chain reaction. PCR abbr. polymerase chain reaction Polymerase chain reaction (PCR) reactions for SNP analysis utilizing standard homogeneous assays. Now, researchers may rapidly test validated SNPs of interest against hundreds or even thousands of DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. samples. "We have been impressed with the BioTrove OpenArray platform in many ways. The BioTrove's flexibility, strong genotyping performance, and throughput capabilities make quality control testing of multiple samples possible using many more genetic markers. In addition, the OpenArrays can be formatted in any configuration to provide for future applications," said Dr. Bruce Elder, Director of Corporate Rodent Genetics at Charles River Laboratories. "We are pleased to be working with a market leader like Charles River. Their implementation of high-throughput sample genotyping will enable them to quickly respond to their customers' needs today with the ability to expand as their genetic testing Genetic Testing Definition A genetic test examines the genetic information contained inside a person's cells, called DNA, to determine if that person has or will develop a certain disease or could pass a disease to his or her offspring. services continue to grow," said Alan Carter, Chief of Commercial Operations. About Charles River Laboratories Charles River Laboratories, based in Wilmington, Massachusetts, U.S., is a global provider of solutions that advance the drug discovery and development process. Our leading-edge products and services are designed to enable our clients to bring drugs to market faster and more efficiently. Backed by our rigorous, best-in-class procedures and our proven data collection, analysis and reporting capabilities, our products and services are organized into three categories spanning every step of the drug development pipeline: Research Models and Services, Preclinical Services, and Clinical Services. Charles River's customer base includes all of the major pharmaceutical companies and many biotechnology companies, government agencies and leading hospitals and academic institutions. Charles River's 8,400 employees serve clients in more than 50 countries. For more information on Charles River, visit our website at www.criver.com. About BioTrove BioTrove offers two innovative platform technologies that dramatically increase the throughput of SNP genotyping and pharmaceutical screening. The OpenArray(TM) platform enables genomics researchers to generate up to hundreds of thousands of data points per day. The flexible format of the OpenArray(TM) plate allows researchers to adjust to their changing needs in sample and assay numbers. Additionally, the nanoliter scale of this flexible system makes high-throughput genotyping economical. RapidFire(TM) Lead Discovery enables drug developers to analyze samples using ultra high-throughput mass spectrometry mass spectrometry or mass spectroscopy Analytic technique by which chemical substances are identified by sorting gaseous ions by mass using electric and magnetic fields. in less than 8 seconds per sample. This technology enables difficult targets (lipids, fatty acids, phospholipids, steroids, and prostaglandins Prostaglandins Prostaglandins are produced by the body and are responsible for inflammation features, such as swelling, pain, stiffness, redness and warmth. ) to be tested using a high-throughput, native detection method. |
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