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CepTor Reports Significant Reduction of Multiple Sclerosis (MS) Symptoms with Oral Delivery of Neurodur in EAE Model.


Results of Animal Testing Using Company's MS Compound Published in the Journal of Neuroimmunology

HUNT VALLEY, Md. -- CepTor Corporation (OTC OTC

See: Over-the-counter.


OTC

See over-the-counter market (OTC).
 BB:CEPO), a biopharmaceutical company focusing on cell-targeted therapeutic products for neuromuscular and neurodegenerative diseases, today announced that the results of Neurodur testing in the Experimental Autoimmune Encephalomyelitis Experimental autoimmune encephalomyelitis (EAE) is an animal model of brain inflammation. It is an inflammatory demyelinating disease of the central nervous system (CNS).  (EAE EAE

1. experimental allergic encephalomyelitis.

2. enzootic abortion of ewes.
) mouse model, the standard animal model used for MS testing, were published in the Journal of Neuroimmunology. The data indicated that the reduction of clinical symptoms of MS in EAE mice treated with oral Neurodur were statistically significant.

Alfred Stracher, Ph.D., Distinguished University Professor of Biochemistry at the State University of New York (body) State University of New York - (SUNY) The public university system of New York State, USA, with campuses throughout the state.  Downstate and co-inventor of the technology, along with Dr. Leo Kesner, Professor Emeritus, stated, "This demonstrates three very important principles: Neurodur can be readily delivered orally; it is extremely effective (p<0.005) in reducing MS symptoms and; represents the proof of principle as a potential therapeutic for MS." Dr. Stracher added, "We also found that Neurodur prevented demyelination demyelination /de·my·elin·a·tion/ (de-mi?e-li-na´shun) destruction, removal, or loss of the myelin sheath of a nerve or nerves. Called also myelinolysis.  (the primary cause of the symptoms of MS) and inflammatory infiltration in a dose and time-dependent manner."

The Chairman and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  of CepTor, Bill Pursley, said, "The nice thing about the standard EAE model is that it allows you to directly address meaningful, clinical (functional) endpoints. These are exciting data in an important indication. This also demonstrates the breadth of our platform technology, cell targeted calpain cal·pain  
n.
A proteolytic enzyme that is regulated by the concentration of calcium ions.



[Probably cal(cium) + p(rote)a(se) + -in.]
 inhibition, in one of several neurodegenerative diseases where the up regulation of calpain plays a key role in the pathophysiology of the disease."

About CepTor Corporation

CepTor Corporation is a development-stage biopharmaceutical company engaged in the discovery, development, and commercialization of proprietary, cell-targeted therapeutic products for the treatment of neuromuscular and neurodegenerative diseases with a focus on orphan diseases. CepTor's primary efforts are currently focused on moving its lead product, Myodur, into clinical trials for Duchenne muscular dystrophy Duchenne muscular dystrophy (DMD)
The most severe form of muscular dystrophy, DMD usually affects young boys and causes progressive muscle weakness, usually beginning in the legs.
. The Company's broad platform technology also includes the development of products for multiple sclerosis (MS), chronic inflammatory demyelinating polyneuropathy Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated inflammatory disorder of the peripheral nervous system but often can have central nervous system involvement. The disorder is sometimes called chronic relapsing polyneuropathy.  (CIDP) and amyotrophic lateral sclerosis amyotrophic lateral sclerosis (ALS) (ā'mīətrōf`ik, sklĭrō`sĭs) or motor neuron disease,  (ALS). More information about CepTor can be found at www.ceptorcorp.com.

The press release contains forward-looking statements. These statements are subject to known and unknown risks and uncertainties that may cause actual future experience and results to differ materially from the statements made. These statements are based on our current beliefs and expectations as to such future outcomes. Drug discovery and development involves a high degree of risk. Factors that might cause such a material difference include, among others, uncertainties related to the ability to attract and retain partners for our technologies, the identification of lead compounds, the successful preclinical development thereof, the completion of clinical trials, the FDA review process and other government regulation on our ability to successfully develop and commercialize drug candidates, competition from other pharmaceutical companies, product pricing and third party reimbursement. The Company disclaims any obligation to update any forward-looking statement as a result of developments occurring after the date of this press release.
COPYRIGHT 2006 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2006, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:Oct 12, 2006
Words:490
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