Center for Risk and Integrated Sciences.The Center for Risk and Integrated Sciences (CRIS) is charged with guiding NIEHS NIEHS National Institute of Environmental Health Sciences (NIH, DHHS) extramural extramural /ex·tra·mu·ral/ (-mur´il) situated or occurring outside the wall of an organ or structure. extramural situated or occurring outside the wall of an organ or structure. research in three main areas: hazardous substance research, "omics" research, and the development and application of emerging technologies in the environmental health sciences. The CRIS program administrators provide service in these areas under the leadership of William A. Suk SUK Sveriges Unga Katoliker (Swedens Young Catholics) . CRIS's oldest program, the Superfund Basic Research Program The Superfund Basic Research Program (SBRP) was created within the National Institute of Environmental Health Sciences in 1986 under the Superfund Amendments and Reauthorization Act (SARA). (SBRP SBRP Superfund Basic Research Program SBRP Schachbund Rheinland-Pfalz SBRP South Bend Raceway Park (North Liberty, IN) SBRP Scottish Borders Rural Partnership (UK) SBRP Special Bridge Replacement Program ), was established in 1986 under the Superfund Amendment and Reauthorization Act. It incorporates biomedical and nonbiomedical research within an interdisciplinary framework. It also has a strong emphasis on interdisciplinary training at the graduate and postdoctoral level; translation of research findings to the environmental and public health community; and the fostering of strong partnerships with the U.S. Environmental Protection Agency Environmental Protection Agency (EPA), independent agency of the U.S. government, with headquarters in Washington, D.C. It was established in 1970 to reduce and control air and water pollution, noise pollution, and radiation and to ensure the safe handling and and the Agency for Toxic Substances and Disease Registry The United States Agency for Toxic Substances and Disease Registry, (ATSDR) is an agency for the U.S. Department of Health and Human Services that is directed by a congressional mandate to perform specific functions concerning the effect on public health of hazardous . In 2000, the NIEHS established the National Center for Toxicogenomics (NCT NCT National Childbirth Trust NCT National Car Test NCT North Carolina Theatre NCT National Coordination Team NCT Northern California TRACON NCT Noise Cancellation Technology NCT Network Control and Timing NCT Nicotine Replacement Therapy ) and charged the Division of Extramural Research and Training with coordinating and harmonizing the Toxicogenomics Research Consortium (TRC TRC Noun (in South Africa) Truth and Reconciliation Commission: a commission which encourages people who committed human rights abuses or acts of terror during the apartheid era to reveal the truth about their crimes in return for immunity from prosecution ), the extramural component of the NCT. Under this rubric, CRIS coordinates the institute's extramural efforts to define how the entire genetic complement of an organism responds to environmental agents. The NIEHS has also recognized the need to explore the biological complexity encoded by the genome by focusing on protein products and metabolic profiling. Accordingly, in support of the goal of reducing risk of exposure, CRIS has assumed the responsibility for fostering the development of portfolios of proteomics and metabolomics research. As these fields evolve, CRIS is positioned to transition this portfolio into the realm of systems biology. In the emerging technology arena, CRIS represents the NIEHS in several trans-NIH program areas including bioengineering, nanosciences, and bioinformatics. Among the areas currently being emphasized are nanoscale technologies (including their potential applications in assessing exposure and risk) and the mechanisms by which exposure leads in the development and progression of disease. CRIS coordinates activities and fosters cooperation on a national and international scale to enhance research efforts in reduce the uncertainty of risk, Toward that end, CRIS manages international programs on chemical safety and health, and coordinates environmental health programs in developing countries. Editor's note: This is the second in a series of articles describing the four extramural program branches at the NIEHS. CRIS Staff William Suk, PhD, MPH-DIRECTOR | suk@niehs.nih.gov TRC, SBRP, international programs Davide Balshaw, PhD-PROGRAM ADMINISTRATOR | balshaw@niehs.nih.gov Emerging technologies, systems biology, proteomics Claudia Thmopson, PhD-PROGRAM ADMINISTRATOR | thompson1@niehs.nih.gov Biomakers of exposure, susceptibility, and effect; SBRP; chemical mixtures Brenda Weis, PhD-PROGRAM ADMINISTRATOR | weis@neihs.nih.gov TRC, toxicogenomics, metabolomics Beth Anderson--PROGRAM ANALYST | tainer@niehs.nih.gov SBRP, Superfund, Small Business Innovation Research program Kathy Ahlmark--TECHNICAL INFORMATION SPECIALIST | ahlmark@niehs.nih.gov SBRP |
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