Cellular crosstalk contributes to asthma, pulmonary hypertension.Byline: ANI Washington, Aug 18 (ANI): Crosstalk between cells lining the lung (epithelial cells Epithelial cells Cells that form a thin surface coating on the outside of a body structure. Mentioned in: Corneal Transplantation ) and airway smooth muscle cells could be linked to lung diseases, such as asthma and pulmonary hypertension Pulmonary Hypertension Definition Pulmonary hypertension is a rare lung disorder characterized by increased pressure in the pulmonary artery. The pulmonary artery carries oxygen-poor blood from the lower chamber on the right side of the heart (right . Already, it is known that such crosstalk is important in lung development. Researchers at the University of Pennsylvania (body, education) University of Pennsylvania - The home of ENIAC and Machiavelli. http://upenn.edu/. Address: Philadelphia, PA, USA. , Philadelphia, have now molecularly characterized one crosstalk pathway in mice, which could provide potential new therapeutic targets for treating individuals with lung diseases, such as asthma and pulmonary hypertension, which are caused, at least in part, by affects on airway smooth muscle cells. The team, led by Edward Morrisey and Ethan David Cohen For other persons named David Cohen, see David Cohen (disambiguation). David Cohen (November 13, 1914 - October 3, 2005), was an American politician, noted for his service in the administration of President Franklin D. , used numerous in vivo in vivo /in vi·vo/ (ve´vo) [L.] within the living body. in vi·vo adj. Within a living organism. in vivo adv. gain- and loss-of-function approaches to demonstrate that a Wnt7b/Tnc/Pdgfr crosstalk pathway was important for mouse smooth muscle development. They also showed that lung epithelial cells exclusively express Wnt7b and the developing airway smooth muscle cells express Pdgfr. Particularly, expression of the components of this crosstalk pathway was upregulated in a mouse model of asthma and humans with pulmonary hypertension. Thus indentifying the Wnt/Tnc/Pdgfr crosstalk pathway is equally important in both lung development and adult lung disease. (ANI) Copyright 2009 Asian News International The Asian News International (ANI) agency provides multimedia news to China and 50 bureaus in India. It covers virtually all of South Asia since its foundation and presently claims, on its official website, to be the leading South Asia-wide news agency. (ANI) - All Rights Reserved. Provided by Syndigate.info an Albawaba.com company |
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