Cellectis bioresearch Launches cGPS[R] Custom - the World's First Line of Kits for Targeted Gene Integration in Native Cell Lines.ROMAINVILLE Romainville is a commune in the eastern suburbs of Paris, France. It is located 7.2 km. (4.5 miles) from the center of Paris. History On July 24, 1867, a part of the territory of Romainville was detached and merged with a part of the territory of Pantin and a part of the , France -- Parc Biocitech -- Cellectis bioresearch bi·o·re·search n. Research in the biological sciences. , a subsidiary of the genome genome: see genetics. genome all the genetic content contained within an organism. An organism's genome is made up of molecules of deoxyribonucleic acid (DNA) that form long strands that are tightly wound into chromosomes, which are found in the engineering company Cellectis SA (Paris:ALCLS), announced today that it has launched cGPS([R]) Custom, a new line of kits for targeted gene integration in native cell lines. This is a breakthrough technology that will enable life science researchers to customize their own cell lines. "cGPS([R]) Custom is the first tool of its kind and with its introduction to the market, researchers will no longer have to buy modified cell lines for performing targeted integration. With cGPS([R]) Custom, they can customize their existing cell lines, offering greater research freedom and considerable time savings", highlighted Marc Le Bozec, CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. of Cellectis bioresearch. The cGPS([R] )Custom line has been developed by leveraging a major innovation from Cellectis SA: modified-specificity meganucleases. Meganucleases are "DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. scissors scissors Cutting instrument or tool consisting of a pair of opposed metal blades that meet and cut when the handles at their ends are brought together. Modern scissors are of two types: the more usual pivoted blades have a rivet or screw connection between the cutting ends " capable of recognizing and cutting a single genomic genomic pertaining to a genome. genomic clone see clone. genomic DNA the DNA sequences making up the genome of an individual. genomic library see gene bank. site with a high degree of accuracy. Each cGPS([R]) Custom kit contains a modified-specificity meganuclease for integrating a gene of interest at a unique, native genomic site in a given cell line. This first product in the cGPS([R]) Custom line enables the generation of stable CHO-K1 clones within a month and has a targeted integration rate of over 90%. In addition, cGPS([R]) Custom kits will allow researchers to continue using their existing cell lines, thus maximizing prior experience. "Our cGPS([R]) and cGPS([R]) Custom products are significantly expanding access to a technology that was previously restricted to a handful of specialists." added Luc Selig, VP Sales & Marketing at Cellectis bioresearch. "Most gene expression experiments are based on transient A malfunction that occurs at random intervals and lasts for a short duration such as a spike or surge in a power line or a memory cell that intermittently fails. See spike and power surge. transient - 1. gene expression because random gene integration previously required considerable time and effort and there was no guarantee of success. The targeted integration cGPS([R]) (cellular Genome Positioning System) lines of products eliminate these issues and are opening up a broad spectrum of new opportunities - not only in fundamental research but also in drug screening and biomanufacturing." About Cellectis bioresearch Cellectis bioresearch was incorporated as a subsidiary of Cellectis SA (Alternext: ALCLS) in June 2008. It provides life science researchers with genome customization kits for rapid, efficient gene integration at a precise genomic position in a given cell type. Two lines of targeted integration kits - cGPS[R] (cellular Genome Positioning System) and cGPS([R]) Custom - are available commercially. For further information about Cellectis bioresearch and to purchase the kits visit www.cellectis-bioresearch.com |
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