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Cell Signaling Technology Announces the Availability of PhosphoScan(R) Profiling Technology and PhosphoSite(R) Knowledgebase to Academic Researchers.

DANVERS, Mass. -- Cell Signaling Technology, Inc. (CST CST
1. Central Standard Time

2. convulsive shock treatment

CST Central Standard Time

Noun 1.
) announced today that it will make PhosphoScan[R] Profiling, CST's proprietary technology based on immunoaffinity purification and tandem mass spectrometry Tandem mass spectrometry, also known as MS/MS, involves multiple steps of mass spectrometry selection, with some form of fragmentation occurring in between the stages. , and information within PhosphoSite[R], CST's knowledgebase focused on phosphorylation phosphorylation, chemical process in which a phosphate group is added to an organic molecule. In living cells phosphorylation is associated with respiration, which takes place in the cell's mitochondria, and photosynthesis, which takes place in the chloroplasts.  of the mammalian proteome pro·te·ome
The complete set of proteins that are produced by the genes of an organism.


the entire complement of proteins produced by a cell.
, available to academic and non-profit researchers.

CST will offer a non-exclusive, non-commercial, royalty-free license to its PhosphoScan[R] patent rights to researchers at academic and not-for-profit institutions. PhosphoScan[R], a proprietary process for identifying specific protein-modification sites, is a versatile technology that enables investigators to identify hundreds of specific protein modification sites in a single experiment. While this technology has primarily been used to characterize phosphorylated and acetylated sites, it can also be used to study all protein modifications. Development of this technology has been supported by CST and multiple SBIR SBIR Small Business Innovation Research (program/grant)
SBIR Space Based Infra-Red
SBIR Speaker-Boundary Interference
SBIR Site Backsurface-referenced Ideal Plane/Range (silicon wafers) 
 grants from the NIH "Not invented here." See digispeak.

NIH - The United States National Institutes of Health.
. CST will continue to commercialize PhosphoScan[R]/AcetylScan[R] technology to corporate entities through research services, alliances and licensing opportunities.

Additionally, the public information related to protein modification sites in PhosphoSite[R] ( will be available to academic and corporate researchers. The public information includes non-redundant sites published in low-throughput papers, high-throughput papers and previously unpublished high-quality MS/MS MS/MS Tandem Mass Spectroscopy
MS/MS Multistage Mass Spectrometry
 sites made public only in PhosphoSite[R]. Regular releases of PhosphoSite[R] data sets will be provided upon request to interested researchers. PhosphoSite[R] is a comprehensive and widely used bioinformatics resource containing experimentally determined sites of phosphorylation in the mammalian proteome. The information in PhosphoSite[R] is curated and edited by Cell Signaling Technology scientists with advanced degrees and years of research experience in signaling and experimental biology. The development of PhosphoSite[R] has been supported by SBIR funding from the NIH and by CST.

"We hope that access to CST's PhosphoScan[R] Profiling technology and the information in PhosphoSite[R] will help accelerate the pace of biomedical research, including the discovery of novel mechanisms of disease, novel biomarkers and potential drug targets," said Michael Comb, Ph.D., the company's CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. .

About Cell Signaling Technology, Inc.

Cell Signaling Technology, Inc. is a worldwide leader in the development and commercialization of phospho-specific antibodies and assays for kinase and pathway analysis, as well as novel discovery technologies such as PhosphoScan[R]. CST's phospho-specific antibodies are validated in multiple assay platforms and are critical reagents in all stages of pharmaceutical drug discovery and development. PhosphoScan[R] leverages CST's core capabilities in antibody development to deliver insight into cellular phosphorylation and acetylation acetylation /acet·y·la·tion/ (ah-set?i-la´shun) introduction of an acetyl radical into an organic molecule.

 profiles enabling more efficient and informative kinase drug discovery and clinical development. Information on CST can be obtained at the Company's website at
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Publication:Business Wire
Date:Oct 31, 2007
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