Cell Signaling Technology Announces Pilot Study for Chiron Corporation to Evaluate CST's PhosphoScan Platform for Kinase Inhibitor Phosphoproteomic Profiling.BEVERLY, Mass. -- Cell Signaling Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as Technology, Inc. (CST CST abbr. 1. Central Standard Time 2. convulsive shock treatment CST Central Standard Time Noun 1. ) announced today an agreement with Chiron Corporation to perform a pilot study employing CST's PhosphoScan(TM) technology to identify phosphorylation phosphorylation, chemical process in which a phosphate group is added to an organic molecule. In living cells phosphorylation is associated with respiration, which takes place in the cell's mitochondria, and photosynthesis, which takes place in the chloroplasts. sites and prospective biomarkers of protein tyrosine kinase tyrosine kinase An enzyme intimately linked to signal transduction–ST, either as a receptor-type TK, which participates in transmembrane signaling, or as an intracellular TK, participating in ST to the nucleus; ↑ or ↓ TK activity is associated with (PTK PTK Phi Theta Kappa PTK Protein Tyrosine Kinase (insulin receptor) PTK Polskiego Towarzystwa Kardiologicznego (Polish Cardiac Society) PTK Phototherapeutic Keratectomy PTK Pairwise Transient Key ) targets. CST's PhosphoScan(TM) phospho-proteomics technology enables the determination of cellular PTK phospho-profiles (Phospho-Signatures(TM)) and can provide direct insight into disease mechanisms and kinase target function. It is based on patent-pending methodologies combining immunoaffinity purification and mass spectroscopy. The phospho-profiles discovered with PhosphoScan(TM) may enable biomarker assays for target validation and kinase inhibitor pharmacodynamics pharmacodynamics /phar·ma·co·dy·nam·ics/ (-di-nam´iks) the study of the biochemical and physiological effects of drugs and the mechanisms of their actions, including the correlation of their actions and effects with their chemical and efficacy. The PhosphoScan(TM) technology was recently described in the journal, Nature Biotechnology (Rush J. et al, Nat. Biotechnol. 23, 94-101 (2005)). "CST is excited about the opportunity to apply its PhosphoScan(TM) technology within the context of Chiron's oncology therapeutic programs to phospho-profile kinase target activation and inhibition, which CST believes could provide information valuable to Chiron," said Christopher Bunker, CST's Director of Business Development. About Cell Signaling Technology, Inc. Cell Signaling Technology, Inc. has expertise and the market leadership position in the development and commercialization of phospho-specific antibodies and assays for kinase and pathway analysis. CST's phospho-specific antibodies are validated in multiple assay platforms and are critical reagents in all stages of pharmaceutical drug discovery and development. CST has leveraged its antibody core capabilities to develop PhosphoScan(TM), a superior phospho-proteomics platform to enable more efficient and informative kinase drug discovery and clinical development. CST's extensive experience using PhosphoScan(TM) has yielded in-depth tyrosine kinase Phospho-Signatures(TM), and with CST's expertise in immunoassay Immunoassay An assay that quantifies antigen or antibody by immunochemical means. The antigen can be a relatively simple substance such as a drug, or a complex one such as a protein or a virus. development, CST can translate information from PhosphoScan(TM) into validated biomarker assays. CST is commercializing the PhosphoScan(TM) technology through research alliances and licensing opportunities. Information on CST can be obtained at the Company's website at www.cellsignal.com |
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