Cell Signaling Technology Announces Pilot Study for Aventis to Employ PhosphoScan Platform for Kinase Phosphoproteomics Analysis.BEVERLY, Mass. -- Cell Signaling Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as Technology, Inc. (CST CST abbr. 1. Central Standard Time 2. convulsive shock treatment CST Central Standard Time Noun 1. ) announced today an agreement with Aventis to perform a pilot study employing CST's PhosphoScan(TM) technology to identify phosphorylation phosphorylation, chemical process in which a phosphate group is added to an organic molecule. In living cells phosphorylation is associated with respiration, which takes place in the cell's mitochondria, and photosynthesis, which takes place in the chloroplasts. sites and prospective biomarkers of protein tyrosine kinase tyrosine kinase An enzyme intimately linked to signal transduction–ST, either as a receptor-type TK, which participates in transmembrane signaling, or as an intracellular TK, participating in ST to the nucleus; ↑ or ↓ TK activity is associated with (PTK PTK Phi Theta Kappa PTK Protein Tyrosine Kinase (insulin receptor) PTK Polskiego Towarzystwa Kardiologicznego (Polish Cardiac Society) PTK Phototherapeutic Keratectomy PTK Pairwise Transient Key ) targets. CST's PhosphoScan(TM) phospho-proteomics technology is a patent-pending methodology combining immunoaffinity purification and mass spectroscopy to determine cellular PTK phosphorylation profiles (TKSignatures(TM)). Biomarkers that are discovered with PhosphoScan(TM) may enable target validation and profiling assays to monitor kinase targeted therapeutic pharmacodynamics pharmacodynamics /phar·ma·co·dy·nam·ics/ (-di-nam´iks) the study of the biochemical and physiological effects of drugs and the mechanisms of their actions, including the correlation of their actions and effects with their chemical and efficacy. "Aventis's integrated kinase program and deep kinase target portfolio provide an ideal context for CST's PhosphoScan(TM) platform to deliver biomarkers of kinase activation-state and inhibition," said Christopher Bunker, CST's Director of Business Development. "These TKSignatures(TM) can provide critical information to enable the development of novel and proprietary assays of efficacy and pharmacodynamics. CST superiority in antibody and immunoassay Immunoassay An assay that quantifies antigen or antibody by immunochemical means. The antigen can be a relatively simple substance such as a drug, or a complex one such as a protein or a virus. development is fully integrated with PhosphoScan, and this can enable CST to translate PhosphoScan discoveries into validated biomarker assays for Aventis." CST's PhosphoScan(TM) platform is a robust and superior methodology for elucidating TKSignatures of protein tyrosine kinase targets. PhosphoScan TKSignatures have been discovered for multiple disease models and targets, and CST has used it to identify thousands of novel phosphorylation sites. About Cell Signaling Technology, Inc. Cell Signaling Technology, Inc. has expertise and the market leadership position in the development and commercialization of phospho-specific antibodies and assays for kinase and pathway analysis. CST's phospho-specific antibodies are validated in multiple assay platforms and are critical reagents in all stages of pharmaceutical drug discovery and development. CST has leveraged its antibody core capabilities to develop PhosphoScan(TM), a superior phospho-proteomics platform that will enable more efficient and informative kinase drug discovery, clinical development, as well as companion diagnostic validation. More information on CST can be obtained at the Company's website at www.cellsignal.com |
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