Cell Signaling Technology Announces Pilot Study Employing; PhosphoScan(TM) Platform for Kinase Phosphoproteomics Analysis.BEVERLY, Mass. -- Cell Signaling Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as Technology, Inc. (CST CST abbr. 1. Central Standard Time 2. convulsive shock treatment CST Central Standard Time Noun 1. ) announced today an agreement with Johnson & Johnson Pharmaceutical Research & Development (J&JPRD JPRD Johnson Pharmaceutical Research Development, LLC JPRD Joint Program Requirement Document ), a division of Janssen Pharmaceutica, N.V, to employ CST's PhosphoScan(TM) technology to identify phosphorylation phosphorylation, chemical process in which a phosphate group is added to an organic molecule. In living cells phosphorylation is associated with respiration, which takes place in the cell's mitochondria, and photosynthesis, which takes place in the chloroplasts. sites and prospective biomarkers kinase targets. CST's PhosphoScan(TM) phospho-proteomics technology enables the determination of cellular phospho-profiles and can provide direct insight into disease mechanisms and kinase target function. It is based on patent-pending methodologies combining immunoaffinity purification and mass spectroscopy. PhosphoScan(TM) can enable biomarker discovery for target validation and kinase inhibitor pharmacodynamics pharmacodynamics /phar·ma·co·dy·nam·ics/ (-di-nam´iks) the study of the biochemical and physiological effects of drugs and the mechanisms of their actions, including the correlation of their actions and effects with their chemical and efficacy. "J&JPRD's targeted therapeutic programs and ability to integrate technologies to advance these programs provide an ideal context for PhosphoScan(TM)," said Christopher Bunker, CST's Director of Business Development. "We can deliver Phospho-Signatures(TM) of kinase target activation and inhibition, which may enable the development of proprietary biomarker assays. CST's exceptional capabilities in antibody and immunoassay Immunoassay An assay that quantifies antigen or antibody by immunochemical means. The antigen can be a relatively simple substance such as a drug, or a complex one such as a protein or a virus. development are fully integrated with PhosphoScan(TM), enabling CST to translate biomarker discoveries into validated, useable assays." About Cell Signaling Technology, Inc. Cell Signaling Technology, Inc. has expertise and the market leadership position in the development and commercialization of phospho-specific antibodies and assays for kinase and pathway analysis. CST's phospho-specific antibodies are validated in multiple assay platforms and are critical reagents in all stages of pharmaceutical drug discovery and development. PhosphoScan(TM) leverages CST's antibody capabilities to enable more efficient and informative kinase drug discovery and development. It is a superior methodology for elucidating phospho-profiles of protein kinase protein kinase /pro·tein ki·nase/ (pro´ten ki´nas) an enzyme that catalyzes the phosphorylation of serine, threonine, or tyrosine groups in enzymes or other proteins, using ATP as a phosphate donor. targets and has been employed to profile hundreds of disease models and primary human tumors for which many thousands of novel phosphorylation sites have been discovered. PhosphoScan(TM) was described in the journal, Nature Biotechnology (Rush J. et al, Nat. Biotechnol. 23, 94-101 (2005)). CST is commercializing PhosphoScan(TM) through research alliances and licensing opportunities. Information on CST can be obtained at the Company's website at www.cellsignal.com |
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