Cell Signaling Technology Announces Partnership with AstraZeneca to Identify Biomarkers for Kinase Inhibitor Lead Compounds.Business Editors/Health/Medical Writers/High-Tech Writers BIOWIRE2K BEVERLY, Mass. & LONDON--(BUSINESS WIRE)--June 7, 2004 Cell Signaling Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as Technology, Inc. (CST CST abbr. 1. Central Standard Time 2. convulsive shock treatment CST Central Standard Time Noun 1. ) announced today an agreement with AstraZeneca to perform a pilot study profiling select AstraZeneca compounds with CST's Global Phospho-Signature(TM) technology to discover novel, informative biomarkers of protein tyrosine kinase tyrosine kinase An enzyme intimately linked to signal transduction–ST, either as a receptor-type TK, which participates in transmembrane signaling, or as an intracellular TK, participating in ST to the nucleus; ↑ or ↓ TK activity is associated with (PTK PTK Phi Theta Kappa PTK Protein Tyrosine Kinase (insulin receptor) PTK Polskiego Towarzystwa Kardiologicznego (Polish Cardiac Society) PTK Phototherapeutic Keratectomy PTK Pairwise Transient Key ) target inhibition. CST's Global Phospho-Signature (GPS(TM)) phospho-proteomics technology is a patent-pending methodology combining immunoaffinity purification and mass spectroscopy mass spectroscope n. Any of various devices that use magnetic fields, electric fields, or both to determine the masses of isotopes in a sample by producing a mass spectrum. to determine cellular PTK phosphorylation phosphorylation, chemical process in which a phosphate group is added to an organic molecule. In living cells phosphorylation is associated with respiration, which takes place in the cell's mitochondria, and photosynthesis, which takes place in the chloroplasts. profiles (TKSignatures(TM)). Biomarkers that are discovered with GPS(TM) may enable the development of profiling assays to monitor targeted therapeutic pharmacodynamics pharmacodynamics /phar·ma·co·dy·nam·ics/ (-di-nam´iks) the study of the biochemical and physiological effects of drugs and the mechanisms of their actions, including the correlation of their actions and effects with their chemical and efficacy. "AstraZeneca's kinase-targeted therapeutics provided an excellent context in which to demonstrate the value of CST's Global Phospho-Signature(TM) capabilities," said Christopher Bunker, CST's Director of Business Development. "The TKSignatures of kinase targets and kinase inhibitor response can provide information to enable the development of valuable and proprietary biomarker assays. CST integrated capabilities in antibody and immunoassay Immunoassay An assay that quantifies antigen or antibody by immunochemical means. The antigen can be a relatively simple substance such as a drug, or a complex one such as a protein or a virus. development will be available to AstraZeneca to rapidly translate GPS discoveries into validated biomarker assays." CST's Global Phospho-Signature(TM) platform is the most comprehensive methodology for elucidating TKSignatures of protein tyrosine kinase targets. GPS TKSignatures have been discovered for multiple disease models and targets, and CST has identified thousands of novel phosphorylation sites. About Cell Signaling Technology, Inc. Cell Signaling Technology, Inc. has expertise and the market leadership position in the development and commercialization of phospho-specific antibodies and assays for kinase and pathway analysis. CST's phospho-specific antibodies are validated in multiple assay platforms and are critical reagents in all stages of pharmaceutical drug discovery and development. CST has leveraged its antibody core capabilities to develop a superior phospho-proteomics platform that will be offered to enable more efficient and informative clinical trial design and strategic Rx/Dx partnership opportunities. More information on CST can be obtained at the Company's website at www.cellsignal.com. About AstraZeneca AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. It is one of the world's leading pharmaceutical companies with healthcare sales of over $18.8 billion and leading positions in sales of gastrointestinal, oncology, cardiovascular, neuroscience and respiratory products. AstraZeneca is listed in the Dow Jones Sustainability Index (Global and European) as well as the FTSE FTSE A company that specializes in index calculation. Although not part of a stock exchange, co-owners include the London Stock Exchange and the Financial Times. Notes: The FTSE is similar to Standard & Poor's in the United States. 4Good Index. Worldwide, AstraZeneca has six major research and development sites, four discovery facilities and a clinical research site, in total, employing more than 11,500 R&D staff members in Canada, France, India, Japan, Sweden, United Kingdom and the United States. For more information about AstraZeneca, please visit http://www.astrazeneca.com. |
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