Cell Signaling Technology Announces Continuation of Collaboration with AstraZeneca to Provide CST's PhosphoScan(R) Platform for Kinase Inhibitor Proteomic Profiling.DANVERS, Mass. -- Cell Signaling Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as Technology, Inc. (CST CST abbr. 1. Central Standard Time 2. convulsive shock treatment CST Central Standard Time Noun 1. ) announced today a third agreement with AstraZeneca under which it will continue to perform CST's PhosphoScan(R) technology to identify phosphorylation phosphorylation, chemical process in which a phosphate group is added to an organic molecule. In living cells phosphorylation is associated with respiration, which takes place in the cell's mitochondria, and photosynthesis, which takes place in the chloroplasts. profiles and prospective biomarkers of kinase targeted lead compounds. CST's PhosphoScan(R) proteomics technology is a patent-pending strategy that enables the discovery of drug target phospho-profiles (Phospho-Signatures(TM)) in cells and disease tissues. The PhosphoScan(R) technology involves immunoaffinity purification and mass spectroscopy mass spectroscope n. Any of various devices that use magnetic fields, electric fields, or both to determine the masses of isotopes in a sample by producing a mass spectrum. and was described in the journal Nature Biotechnology Nature Biotechnology (Nat Biotechnol; ISSN 1087-0156) is an academic journal covering the science and business of biotechnology. Nature Biotechnology is a continuation of Bio/technology (Biotechnology (NY) (Rush J. et al, Nat. Biotechnol. 23, 94-101 (2005)). The Phospho-Signatures(TM) discovered using PhosphoScan(R) may enable biomarker biomarker /bio·mark·er/ (bi´o-mahr?ker) 1. a biological molecule used as a marker for a substance or process of interest. 2. tumor marker. bi·o·mark·er n. 1. assays for target validation and therapeutic kinase inhibitor clinical development. "Our on-going relationship with AstraZeneca has enabled to CST apply its phosphoproteomics capabilities to deliver valuable information supporting AstraZeneca's kinase inhibitor programs," said Christopher Bunker, CST's Director of Business Development. "PhosphoScan(R) has provided value to our partners as well as to CST's internal cancer research programs, particularly in understanding tyrosine kinase tyrosine kinase An enzyme intimately linked to signal transduction–ST, either as a receptor-type TK, which participates in transmembrane signaling, or as an intracellular TK, participating in ST to the nucleus; ↑ or ↓ TK activity is associated with activation and inhibitor mechanism of action. CST has in addition recently implemented methods for serine/threonine kinase PhosphoScan(R) profiling, as well as quantification strategies, which further enhance CST's ability to focus on the most relevant biomarkers of kinase target activation and inhibition. AstraZeneca can also benefit, under our agreement, from CST's expertise in antibody and immunoassay Immunoassay An assay that quantifies antigen or antibody by immunochemical means. The antigen can be a relatively simple substance such as a drug, or a complex one such as a protein or a virus. development for biomarkers discovered using PhosphoScan(R)." About Cell Signaling Technology Cell Signaling Technology is the market leader in the development and commercialization of phospho-specific antibodies and assays for kinase and pathway analysis. CST's phospho-specific antibodies are validated in multiple assay platforms and are critical reagents in all stages of pharmaceutical drug discovery and development. PhosphoScan(R) leverages CST's core capabilities in antibody development to deliver unparalleled insight into cellular phosphorylation profiles enabling more efficient and informative kinase drug discovery and clinical development. CST is commercializing the PhosphoScan(R) technology through research alliances and licensing opportunities. More information can be obtained at the Company's website www.cellsignal.com |
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