CareGuide/Patient Infosystems Announces 3-Year Contract Renewal with the State of Louisiana Office of Group Benefits.

CORAL SPRINGS, Fla. -- Patient Infosystems, Inc. (OTCBB: PATY) ("CareGuide/Patient Infosystems"), a health and care management company, today announced the renewal of its contract with the State of Louisiana Office of Group Benefits ("Louisiana OGB").

Since October 2003, CareGuide/Patient Infosystems has been providing utilization review and case management services for 60,000 State of Louisiana employees and their families. During this time, CareGuide/Patient Infosystems has achieved in excess of $25 Million dollars in savings for this group. This success can be attributed to CareGuide/Patient Infosystems' collaborative, proactive approach to medical management. A close working relationship with the Louisiana OGB staff over the past three years has allowed CareGuide/Patient Infosystems to provide the necessary support to ensure appropriate care of their members and effective communication and collaboration with contracted providers. The care management nurses have worked very closely with the Louisiana OGB providers to prevent inappropriate hospitalizations. When hospitalizations have been necessary, the nurses have assisted with discharge planning to ensure a safe return to their prior level of function, or to an alternatively appropriate level of care, continuously working to optimize the members' benefits while ensuring appropriate, cost-effective care.

With the success of these programs, the Louisiana OGB has renewed its contract with CareGuide/Patient Infosystems for an additional 3 years. Chris Paterson, CareGuide/Patient Infosystems' CEO stated, "Working together, CareGuide/Patient Infosystems and Louisiana OGB have saved significant healthcare dollars for the State. We are pleased with the opportunity to continue working with the Louisiana OGB in their efforts to control healthcare cost trend while maintaining and enhancing employee satisfaction with benefits."

The renewal of this contract was mentioned, without specific identification, in the press release issued by the Company on May 10, 2006.

ABOUT CAREGUIDE/PATIENT INFOSYSTEMS

CCS Consolidated, Inc. (d/b/a CareGuide) and Patient Infosystems have merged to create a uniquely positioned, single-source provider of information-based health and care management services. The company's technology platform translates population data into actionable information, leading to targeted interventions tailored to the individual. The company's multidisciplinary care management teams are focused on consistent execution of physician-guided evidence-based care planning, producing optimal health outcomes by empowering individuals and connecting a fragmented health care support system. Services include care management (telephonic and onsite), utilization management, disease management, complex care management, health risk assessments, maternity management, a 24-hour nurse help line, and provider quality improvement services. Any combination of available services can be fully integrated with one another or carved out to enhance a client's existing plan design. Visit www.careguide.com and www.ptisys.com for more information.

ABOUT LOUISIANA OFFICE OF GROUP BENEFITS

The Office of Group Benefits is the second largest payer of employer-sponsored health insurance claims in Louisiana. The self-insured, self-administered program provides life and health benefits to over 250,000 Louisiana plan members and their families.

SAFE HARBOR PROVISIONS

This release contains information about management's view of the company's future expectations, plans and prospects, our ability to reduce costs for our clients, to benefit their businesses and our ability to recognize our goals for 2006 that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995. Actual results may differ materially from historical results or those indicated by these forward-looking statements as a result of a variety of factors including, but not limited to, risks and uncertainties associated with the company's financial condition, its ability to sell its products, its ability to compete with competitors and the growth of the healthcare market as well as other factors that are discussed in Patient Infosystems' Annual Report on Form 10-KSB for the year ended December 31, 2005 filed with the SEC on March 31, 2006, in the Form 8-K/A filed with the SEC on March 8, 2006, in the Form 8-K filed with the SEC on May 11, 2006, in the Form SB-2 filed with the SEC on May 15, 2006 as well as other documents filed by Patient Infosystems with the SEC.