CareGuide/Patient Infosystems, Inc. Announces Contract to Serve Medicaid Recipients in New York City.

CORAL SPRINGS, Fla. -- Patient Infosystems, Inc. (OTCBB: PATY) ("CareGuide/Patient Infosystems, Inc."), a health and care management company, today announced a $1.9 million contract with the New York State Department of Health for a two-year regional Medicaid demonstration project to address the complex healthcare needs of Fee-for-Service Medicaid enrollees in New York City. CareGuide/Patient Infosystems will provide disease and care management services for Congestive Heart Failure, Diabetes, Coronary Artery Disease, and Chronic Obstructive Pulmonary Disease. The Company was awarded the Manhattan Region for this project which includes Harlem, Morningside Heights and Hamilton Heights.

For these demonstration projects, the State was seeking innovative approaches to disease and care management in an effort to promote and support the physician/patient relationship for quality health care delivery, improved understanding of treatment options and increased patient involvement in managing their own care. These principles are at the foundation of CareGuide/Patient Infosystems' programs, which emphasize high-touch, personal interactions with participants and improved communication and collaboration among the care team. The State will evaluate each regional program in order to better understand the efficacy of the various care models.

Chris Paterson, CareGuide/Patient Infosystems' CEO, "New York State is showing a great commitment to the health and well being of its residents through these demonstration projects, and CareGuide/Patient Infosystems is excited to be part of such an important initiative. We understand the unique needs and challenges inherent in caring for this population and we are confident in our ability to engage the Medicaid recipients in New York City. Our objective will be to successfully connect individuals to the necessary resources for better care, and to work with them on key self management skills to improve their health, providing the necessary guidance to ensure success. We also believe our care model will lead to meaningful improvements in the health outcomes of these individuals and corresponding reductions in Medicaid expenditures."

"The merger of CareGuide and Patient Infosystems, Inc. created a strong platform from which to serve this program in New York City by providing a complete and integrated set of products to assist the chronically ill," according to Paterson. "The contract with the New York State Department of Health reflects our commitment to public sector pursuits in addition to commercial ventures."

ABOUT CAREGUIDE/PATIENT INFOSYSTEMS

CCS Consolidated, Inc. (d/b/a CareGuide) and Patient Infosystems have merged to create a uniquely positioned, single-source provider of information-based health and care management services. The company's technology platform translates population data into actionable information, leading to targeted interventions tailored to the individual. The company's multidisciplinary care management teams are focused on consistent execution of physician-guided evidence-based care planning, producing optimal health outcomes by empowering individuals and connecting a fragmented health care support system. Services include care management (telephonic and onsite), utilization management, disease management, complex care management, health risk assessments, maternity management, a 24-hour nurse help line, and provider quality improvement services. Any combination of available services can be fully integrated with one another or carved out to enhance a client's existing plan design. Visit www.careguide.com and www.ptisys.com for more information.

SAFE HARBOR PROVISIONS

This release contains information about management's view of the company's future expectations, plans and prospects, our ability to reduce costs for our clients, to benefit their businesses and our ability to recognize our goals for 2006 that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995. Actual results may differ materially from historical results or those indicated by these forward-looking statements as a result of a variety of factors including, but not limited to, risks and uncertainties associated with the company's financial condition, its ability to sell its products, its ability to compete with competitors and the growth of the healthcare market as well as other factors that are discussed in Patient Infosystems' Annual Report on Form 10-KSB for the year ended December 31, 2005 filed with the SEC on March 31, 2006 and in the Form 8-K/A filed with the SEC on March 8, 2006, as well as other documents filed by Patient Infosystems with the SEC.