Carbon monoxide exposure and carboxyhemoglobin: response.In his letter, Donnay objects to the inclusion in our paper (Devine et al. 2002) of a table (Table 2) describing signs and symptoms associated with several levels of carbon monoxide exposure and carboxyhemoglobin carboxyhemoglobin /car·boxy·he·mo·glo·bin/ (-he´mo-glo?bin) hemoglobin combined with carbon monoxide, which occupies the sites on the hemoglobin molecule that normally bind with oxygen and which is not readily displaced from the molecule. (HbCO) blood saturation. This table presents a historical perspective on the known physical effects of CO. The information contained in it is very different from that summarized in the case report, which details subtle effects of chronic low-level CO exposure on behavioral and cognitive function. Our Table 2, which was not included in the initial submission of this paper to EHP, was added at the request of reviewers. It was felt that such a table would provide a comparison point regarding historical, longstanding beliefs about CO effects. In the case report, this knowledge is compared to more recent research and clinical reports of CO effects and their relationship to HbCO. We do not see a compelling reason for retracting the table from the paper, especially given the context of our presentation on subtle effects of CO. The authors declare they have no conflict of interest. REFERENCE Devine SA, Kirkley SM, Palumbo CL, White RF. MRI 1. (application) MRI - Magnetic Resonance Imaging. 2. MRI - Measurement Requirements and Interface. and neuropsychological neu·ro·psy·chol·o·gy n. The branch of psychology that deals with the relationship between the nervous system, especially the brain, and cerebral or mental functions such as language, memory, and perception. correlates of carbon monoxide exposure: a case report. Environ Health Perspect 110:1051-1055 (2002). Roberta F. White Department of Environmental Health Boston University School of Public Health Boston University School of Public Health (BUSPH) is Boston University's graduate School of Public Health. It is located in the heart of Boston University's Medical Campus in the South End neighborhood of Boston, Massachusetts. The Dean is Robert Meenan. Boston, Massachusetts E-mail: rwhite@bu.edu Sherral Devine The Framingham Study Framingham, Massachusetts Shalene Kirkley Department of Psychology University of Alabama The University of Alabama (also known as Alabama, UA or colloquially as 'Bama) is a public coeducational university located in Tuscaloosa, Alabama, USA. Founded in 1831, UA is the flagship campus of the University of Alabama System. Tuscaloosa, Alabama Carole Palumbo Department of Neurology Boston University School of Medicine Boston University School of Medicine (BUSM) is one of the graduate schools of Boston University. It is an American medical school located in the South End neighborhood of Boston, Massachusetts. Boston, Massachusetts |
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