Cancer vaccines lead to long-term survival for skin cancer patients.Byline: ANI Washington, July 29 (ANI): In a new study, researchers have shown that patient-specific cancer vaccines Cancer vaccines A treatment that uses the patient's immune system to attack cancer cells. Mentioned in: Pancreatic Cancer, Exocrine can lead to long-term survival for patients with metastatic Metastatic The term used to describe a secondary cancer, or one that has spread from one area of the body to another. Mentioned in: Coagulation Disorders metastatic pertaining to or of the nature of a metastasis. melanoma, whose disease had been minimized by other therapies.atient-specific cancer vaccines are derived from patients' own cancer cells and immune cells. "There is continued interest in developing new therapies for melanoma patients with recurrent or distant metastatic disease at the time of diagnosis because there are no systemic therapies that can be relied upon to cure them. Patients with metastatic melanoma are at high risk for additional metastases Metastasis (plural, metastases) A tumor growth or deposit that has spread via lymph or blood to an area of the body remote from the primary tumor. Mentioned in: Malignant Melanoma and death," said Dr. Robert O. Dillman, executive medical and scientific director at the Hoag Cancer Center and lead investigator for the study. For the study, 54 patients with regionally recurrent or distant metastatic melanoma were injected with a vaccine that included each patient's own immune cells (dendritic cells) and 500 micrograms of granulocyte-colony stimulating factor (GM-CSF GM-CSF granulocyte-macrophage colony-stimulating factor. Granulocyte/macrophage colony stimulating factor (GM-CSF) A substance produced by cells of the immune system that stimulates the attack upon foreign cells. ), an immune stimulator, three times a week and then monthly for five months for a total of up to eight injections. The researchers then obtained patient's dendritic cells from their peripheral blood peripheral blood Cardiology Blood circulating in the system/body , and mixed them with a cell culture of the patient's own melanoma cells that had been self-renewing and proliferating in the laboratory. The patient-specific vaccine is designed to stimulate the patient's immune system immune system Cells, cell products, organs, and structures of the body involved in the detection and destruction of foreign invaders, such as bacteria, viruses, and cancer cells. Immunity is based on the system's ability to launch a defense against such invaders. to react against tumour stem cells stem cells, unspecialized human or animal cells that can produce mature specialized body cells and at the same time replicate themselves. Embryonic stem cells are derived from a blastocyst (the blastula typical of placental mammals; see embryo), which is very young or early progenitor cells that can create new depots of cancer throughout the body. Data showed that the projected five-year survival rate was 54 percent at a median follow up of 4.5 years (range 2.4 to 7.4) for the 30 surviving patients. The results were found to be superior to those observed following vaccination with irradiated tumour cells in 48 melanoma patients in a previous trial. Eight patients in the dendritic cell vaccine study experienced remarkable long-term, progression-free survival after completing the vaccine therapy, even though they had widely metastatic disease and/or repeated appearance of new metastases despite various therapies. The vaccine treatment was well tolerated, with most patients experiencing mild skin irritation and redness at the injection site. "The one-year and projected five-year survival rates of 85% and 54%, respectively, are remarkable for melanoma patients with documented metastatic disease. This study is extremely encouraging and shows the potential these types of personalized cancer vaccines have for patients diagnosed with metastatic melanoma," said Dillman. The study has been published in Cancer Biotherapy biotherapy /bio·ther·a·py/ (-ther´ah-pe) biological therapy. bi·o·ther·a·py n. Treatment of disease with biologicals, such as vaccines. and Radiopharmaceuticals. (ANI) Copyright 2009 Asian News International The Asian News International (ANI) agency provides multimedia news to China and 50 bureaus in India. It covers virtually all of South Asia since its foundation and presently claims, on its official website, to be the leading South Asia-wide news agency. (ANI) - All Rights Reserved. Provided by Syndigate.info an Albawaba.com company |
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