Cancer Vaccine Research Is Coming To Fruition, With A Number Of Products Now In Phase III Trials And 15 Therapeutic Cancer Vaccines Realistically Expected To Launch By 2013.DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/research/eb249c/cancer_vaccine_dev) has announced the addition of the "Cancer Vaccine The term cancer vaccine is often used to describe a process whereby a person's immune system is coaxed into recognizing and destroying malignant cells without harming normal cells. Developments to 2013 + Cancer Vaccine Tracker" report to their offering. The launch of Sanofi Pasteur Sanofi pasteur is the vaccine division of sanofi-aventis Group. It is the largest company in the world devoted entirely to vaccines. History In 2004, Aventis merged with and into Sanofi. The new sanofi-aventis Group became the world's 3rd largest pharmaceutical company. MSD's Gardasil and GSK's Cervarix has propelled cancer vaccines Cancer vaccines A treatment that uses the patient's immune system to attack cancer cells. Mentioned in: Pancreatic Cancer, Exocrine from research obscurity to a key area of commercial and clinical interest. But can the sector capitalise on these gains and really fulfil its promise? By 2010, the global cancer market is expected to generate sales in excess of US$60 billion due to growth in the sales of existing innovative products and the launch of nearly 60 new products which will account for around 30% of total drug launches. But where do cancer vaccines fit into this outlook? At present, prophylactic vaccines dominate the cancer vaccine sector following the recent launches of Sanofi Pasteur MSD's Gardasil and GlaxoSmithKline's Cervarix. We expect that sales of these vaccines will break through US$4 billion by 2011. While there is no therapeutic vaccine therapeutic vaccine Immunology A vaccine–eg, Salk's Remune™ intended to treat a viral infection by stimulating the immune system. See Vaccine therapy. market, so to speak of, at present, it has the potential to mirror the growth seen in the monoclonal antibody monoclonal antibody, an antibody that is mass produced in the laboratory from a single clone and that recognizes only one antigen. Monoclonal antibodies are typically made by fusing a normally short-lived, antibody-producing B cell (see immunity) to a fast-growing market, and reach sales in excess of US$5 billion by 2012. This prediction may be optimistic and is highly dependent on vaccines being approved for major cancer indications - no small challenge taking the development history of the sector. While no new therapeutic cancer vaccine has been approved recently the product pipeline has changed substantially, shifting from one filled with vaccines at the Phase I and II stage, to a more mature pipeline reflecting a shift in development towards the later stages. This is a consequence, not only of the age of the pipeline, but of the difficulties and pitfalls that therapeutic cancer vaccine development faces. Many vaccines have fallen by the wayside for one reason or another. Indeed the rush to join this area of research has waned slightly with the realisation that products are harder to bring to market than first anticipated. Cancer vaccine research is coming to fruition, with a number of products now in Phase III trials and 15 therapeutic cancer vaccines realistically expected to launch by 2013 Despite the challenges faced by the sector, we predict that by 2010, there will be six new therapeutic cancer vaccine approvals, led by Favrille's FavId for B-cell non-Hodgkin's lymphoma non-Hodg·kin's lymphoma n. Any of various malignant lymphomas characterized by the absence of Reed-Sternberg cells. Non-Hodgkin's lymphoma . This number looks set to increase quickly with the possibility of 21 vaccines being launched by the end of 2013, although 15 seems a more realistic scenario given the historic failure rate for therapeutic cancer vaccines in Phase III development. These products look set to target some of the "big" cancers, with launches for vaccines against renal cell carcinoma renal cell carcinoma or hypernephroma Malignant tumour of the cells that cover and line the kidney. It usually affects persons over age 50 who have vascular disorders of the kidneys. It seldom causes pain, unless it is advanced. , melanoma, prostate, non-small cell lung and colorectal cancer colorectal cancer Malignant tumour of the large intestine (colon) or rectum. Risk factors include age (after age 50), family history of colorectal cancer, chronic inflammatory bowel diseases, benign polyps, physical inactivity, and a diet high in fat. . But there are many challenges ahead It is still not clear how best to use cancer vaccines with respect to disease stage and in combination with other therapies. How should clinical trials be designed so that the endpoints reflect the actions of the vaccines? It looks likely that when therapeutic cancer vaccines finally make their way on to the market and into clinical use it will be alongside current therapies as part of combination regimens that keep cancer in check. The current vaccines in development do not seem to be the "magic bullet (jargon) magic bullet - (Or "silver bullet" from vampire legends) A term widely used in software engineering for a supposed quick, simple cure for some problem. E.g. "There's no silver bullet for this problem". " for cancer that many had hoped they would be. Instead they look set to occupy a much needed place in the growing choice of treatments that are needed to keep cancer under control. The problems faced by the sector are illustrated by Dendreon's Provenge. Everything was right: a biotech company getting a vaccine approved for a major indication in a large market. However, this was not to be, as the FDA FDA abbr. Food and Drug Administration FDA, n.pr See Food and Drug Administration. FDA, n.pr the abbreviation for the Food and Drug Administration. ruled that additional survival data was needed, signalling another setback for a sector that has seen its fair share of failures and false dawns. But it was also a timely reminder for developers that the path to market for therapeutic cancer vaccines is not going to be an easy one. Companies must now focus on conducting well-designed trials with achievable but robust endpoints in suitable patient populations, and perhaps even consider combination trials with other therapies. Who are the players and products in the race to launch? This report critically assesses the candidates in their wider market context This insightful and data-rich management report Cancer Vaccine Developments to 2013, fully evaluates the products and their developers. In more than 180 pages, the report provides a complete review of the market and its likely development to 2013. The report answers key questions... * Who's developing what, and with whom? * What are the prospects for Gardasil achieving US$1.6 billion sales by 2011? * Which products are likely to launch in 2009 and 2010? * Why do some cancer vaccines fail? * Which company is leading the race to develop a breast cancer vaccine? * What cancer vaccines are there in Phase II/III for lung, breast, prostate and colorectal cancer? * What unique regulatory hurdles must cancer vaccines overcome? Incorporating information from our extensive cancer databases, case studies and direct contact with developers, the report provides unique insight, forecasts, product launch predictions and much, much more. Essential reading for investors, developers and industry professionals! Cancers covered * Brain * Breast * Gastrointestinal * Genito-urinary * Gynaecological adj. 1. Of or pertaining to gynecology; same as gynecological. Adj. 1. gynaecological - of or relating to or practicing gynecology; "gynecological examination" gynecologic, gynecological * Haematological Adj. 1. haematological - of or relating to or involved in hematology hematologic, hematological * Lung * Melanoma/Sarcoma Types of cancer vaccine * Antigen/adjuvant vaccines * Whole-cell tumour vaccines * Dendritic cell dendritic cell n. 1. A cell that has branching processes. 2. Any of the cells in the neural crest of the embryonic ectoderm having extensive processes and developing early as producers of melanin. vaccines * Viral vectors and DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. vaccines * Idiotype id·i·o·type n. A determinant that confers on an immunoglobulin molecule an antigenic individuality that is analogous to the individuality of the molecule's antibody activity. vaccines This report includes the CANCER VACCINE TRACKER If you need to stay in touch with the latest developments in cancer vaccines, then you should use the unique online service Cancer Vaccine Tracker. Updated on an ongoing basis, the Tracker will keep you up-to-date with the very latest product, regulatory, company and research developments. Available to buyers of the online edition of this report. For more information visit http://www.researchandmarkets.com/research/eb249c/cancer_vaccine_dev Source: Espicom Business Intelligence Introduction Espicom Business Intelligence is a publisher of independent and impartial information and analysis services focusing on the pharmaceutical and medical device markets. Ltd |
|
||||||||||||||
Printer friendly
Cite/link
Email
Feedback
Reader Opinion