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Callisto Pharmaceuticals Announces Appointment of New Members of the Board of Directors.


Business Editors/Health/Medical Writers

NEW YORK--(BUSINESS WIRE)--June 30, 2003

Certain Management Changes in Connection with the Merger Agreement

with Synergy Pharmaceuticals Inc.

Callisto Pharmaceuticals, Inc. (OTCBB OTCBB

See OTC Bulletin Board (OTCBB).
: CLSP CLSP Center for Language and Speech Processing
CLSP Cisco Learning Solutions Partner
CLSP Channel Load Sensing Protocol
CLSP Community Legal Services Program
CLSP Clinical Laboratory Sciences Program
CLSP Center for Law and Social Policy
) announced that in connection with its merger with Synergy Pharmaceuticals Inc., new members of the Board of Directors have been appointed and certain changes have been made to management.

The new Board of Directors consists of Gabriel M. Cerrone, the Acting Chairman of the Board, Christoph Bruening, Iain Ross, Edwin Snape and Albert J. Henry. In addition, Gary S. Jacob, Ph.D. has been appointed Acting Chief Executive Officer in addition to his duties as Chief Scientific Officer, Kunwar Shailubhai, Ph.D. has been appointed Executive Vice President and Head of Research and Development and Donald Picker, Ph.D. has been appointed Vice President, Drug Development.

Callisto is a biopharmaceutical company focused on the development of drugs to treat multiple myeloma, other cancers and osteolytic osteolytic adjective Causing bone breakdown  bone disease. Callisto's lead drug candidate, Atiprimod, is a small-molecule, orally available drug with antiproliferative and antiangiogenic an·ti·an·gi·o·gen·ic
adj.
Inhibiting the growth of blood vessels.


antiangiogenic
 activity. Atiprimod successfully completed Phase I clinical trials in rheumatoid arthritis patients and Callisto plans to enter Atiprimod in a safety and proof-of-principle clinical trial in multiple myeloma patients. Callisto intends to submit to the FDA FDA
abbr.
Food and Drug Administration


FDA,
n.pr See Food and Drug Administration.

FDA,
n.pr the abbreviation for the Food and Drug Administration.
 by August 2003 an IND to treat multiple myeloma patients. The drug is also being explored as an agent to treat osteolytic bone disease. In addition, Callisto has programs focused on the development of an analog of the human intestinal hormone, uroguanylin, to treat colon cancer, and drugs to protect against staphylococcal and streptococcal streptococcal /strep·to·coc·cal/ (-kok´al) pertaining to or caused by a streptococcus.
Streptococcal (Streptococcus)
Pertaining to any of the Streptococcus bacteria.
 bioweapons, as a protection against the devastating effects of toxic shock syndrome toxic shock syndrome (TSS). acute, sometimes fatal, disease characterized by high fever, nausea, diarrhea, lethargy, blotchy rash, and sudden drop in blood pressure. It is caused by Staphylococcus aureus, an exotoxin-producing bacteria (see toxin). . Callisto has two operating subsidiaries, Callisto Research Labs, LLC (Logical Link Control) See "LANs" under data link protocol.

LLC - Logical Link Control
 and Synergy Pharmaceuticals Inc.

Included in this release are "forward-looking: statements. Such statements are indicated by words such as "expect," "should," "anticipate" and similar words indicating uncertainty in facts and figures. Although Callisto believes that the expectations reflected in such forward-looking statements are reasonable, it can give no assurance that such expectations reflected in such forward-looking statements will prove to have been correct. Callisto's actual results could differ materially from those anticipated in the forward-looking statements as a result of various factors.
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Publication:Business Wire
Geographic Code:1USA
Date:Jun 30, 2003
Words:365
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