Calcium and vitamin D.

Nutraceutical: Calcium and vitamin D

Indication: Weight gain (postmenopausal women)

Source: Arch Intern Med, May 14, 2007;167(9):893-902.

Research: A randomized, double-blind, placebo-controlled trial was performed with 36,282 postmenopausal women, aged 50 to 79 years, who were already enrolled in the dietary modification and/or hormone therapy arms of the Women's Health Initiative clinical trial. Women were randomized at their first or second annual visit to receive a dose of 1000 mg of elemental calcium plus 400IU of cholecalciferol (vitamin D) or placebo daily. Change in body weight was ascertained annually for an average of 7 years.

Results: Women receiving calcium plus cholecalciferol supplements vs. women receiving placebo had a minimal but consistent favorable difference in weight change. After 3 years of follow-up, women with daily calcium intakes less than 1200 mg at baseline who were randomized to supplements were 11% less likely to experience small weight gains (1-3 kg) and 11% less likely to gain more moderate amounts of weight. The greatest benefits were seen in women who began the study with inadequate calcium intakes--those consuming less than the current recommendation of 1200 mg of calcium per day. As a result, researchers believe these latest findings do not justify altering current dietary recommendations, and that postmenopausal women should continue to be advised to consume 1.200 mg a day of calcium.