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CYGX's Single-Stranded DNA Expression System is Highlighted at `Gene Odyssey' Conference.


Business Editors & Health/Medical Writers

HOUSTON--(BUSINESS WIRE)--Jan 16, 2001

CytoGenix Inc.(CYGX) Vice President of Research and Development, Jonathan F. Elliston, Ph.D., J.D., and Chief Research Scientist, Yin Chen, Ph.D. attended the "Gene Therapy 2001: A Gene Odyssey" Keystone Symposia held this past week, Jan. 6th through Jan. 11th, in Snowbird, Utah Snowbird is a locale based in Little Cottonwood Canyon in the Wasatch Range of the Rocky Mountains in Utah. It is perhaps most famous for the Snowbird ski resort, an alpine skiing and snowboarding area, which opened in December 1971. , to present the Company's most recent research studies on intracellular single-stranded DNA DNA: see nucleic acid.
DNA
 or deoxyribonucleic acid

One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes.
 expression of catalytic DNA in human lung The human lungs are the human organs of respiration.

Humans have two lungs, with the left being divided into two lobes and the right into three lobes. Together, the lungs contain approximately 1500 miles (2,400 km) of airways and 300 to 500 million alveoli, having a total
 cancer cells cells once believed to be peculiar to cancers, but now know to be epithelial cells differing in no respect from those found elsewhere in the body, and distinguished only by peculiarity of location and grouping.

See also: Cancer
.

One of the main attractions of this years conference was the inclusion of emerging technologies in the world of gene therapy. These "newcomer" sessions included CYGX's presentation entitled "Novel Intracellular Single-Stranded DNA Expression System: Production of c-raf RNA-cleaving DNA Enzyme" and received significant attention by the participants as well as the media who provided a news release on the novel technology that can be found at www.newscientist.com.

CYGX's research team showed how to utilize their intracellular DNA expression system to produce DNA enzymes against a particular protein within lung cancer lung cancer, cancer that originates in the tissues of the lungs. Lung cancer is the leading cause of cancer death in the United States in both men and women. Like other cancers, lung cancer occurs after repeated insults to the genetic material of the cell.  cells. Down regulation of these proteins resulted in cancer cell death. Dr. Elliston, one of the members of the CYGX research team commented, "Oligonucleotide-mediated therapeutic intervention is definitely an emerging technology in the world of gene therapy, and I am pleased that our unique single-stranded DNA expression system and its application to DNA enzymes that destroy cancer cells has caught the attention of not only researchers in the field but also the media."

CYGX is a Houston-based, biotechnology company pursuing research, development and commercialization of single-stranded DNA (ssDNA) technology. CYGX has developed proprietary intracellular expression system technology (TroVec(TM) and EnzSyn(TM)) to produce desired sequence-specific, ssDNA in individual cells for the purpose of triplex triplex /tri·plex/ (tri´pleks) triple or threefold.

triplex

triple or threefold.
, antisense antisense, DNA or RNA manipulated in a laboratory so that its components (nucleotides) form a complementary copy of normal, or "sense," messenger RNA (mRNA; see nucleic acid). , catalytic DNA and aptamer applications. Basic research is being conducted in the CytoGenix Laboratory in Houston with additional studies underway through sponsored research agreements with various universities and medical research facilities throughout the United States.

SAFE HARBOR Safe Harbor

1. A legal provision to reduce or eliminate liability as long as good faith is demonstrated.

2. A form of shark repellent implemented by a target company acquiring a business that is so poorly regulated that the target itself is less attractive.
: Except for statements of historical fact, the statements in this press release are forward-looking. Such statements are subject to a number of risks and uncertainties that could cause actual results to differ materially from the statements made. These factors include, but are not limited to, general economic conditions, risks associated with the acceptance of new products, competition and other factors more fully detailed in the company's filings with the Securities and Exchange Commission.
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No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2001, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:Jan 16, 2001
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