CRUCELL/DSM SIGN LICENSING PACT WITH MITSUBISHI PHARMA.

Dutch biotechnology company Crucell N.V. (Euronext, NASDAQ: CRXL) has announced that allied contract manufacturer DSM Biologics has signed a PER.C6 research license agreement with the Japanese pharmaceutical company Mitsubishi Pharma Corporation. This license agreement allows Mitsubishi to use the PER.C6 cell line for production of certain recombinant therapeutic proteins. This license agreement is the second license agreement signed by DSM Biologics with a Japanese company recently.

Under the terms of the agreement, Mitsubishi will make an upfront payment and pay annual maintenance fees. Further financial details were not disclosed.

About CrucellP Crucell N.V. is a biotechnology company focused on developing vaccines and antibodies that prevent and treat infectious diseases, including Ebola, influenza, malaria, West Nile virus and rabies. The company's development programs include collaborations with Sanofi Pasteur for influenza vaccines, the U.S. National Institutes of Health for Ebola and malaria vaccines, and GlaxoSmithKline (GSK), Walter Reed Army Institute of Research and New York University for a malaria vaccine. Crucell's products are based on its innovative PER.C6 technology, which offers a safer, more efficient way to produce biopharmaceuticals. The company licenses its PER.C6 technology to the biopharmaceutical industry on a mostly non- exclusive basis. Licensees and partners include DSM Biologics, GSK, Centocor/J&J and Merck & Co., Inc. Crucell is headquartered in Leiden, The Netherlands, and is listed on the Euronext and NASDAQ stock exchanges (ticker symbol CRXL).

For more information, visit http://www.crucell.com.

About DSM Biologics

DSM Biologics, a business unit of the DSM Pharmaceutical Products business group, is one of the world's leading contract manufacturers of biopharmaceutical products, the latest generation of drugs, mainly on the basis of native molecules and produced with the help of cell cultures. The company is renowned for its experience in the use of a broad range of cell culture systems (microbial and mammalian) and its expertise in the field of purification techniques. The company has an exclusive license to use the high-producing PER.C6 human cell line as a production platform for recombinant proteins and monoclonal antibodies. Established in 1986, DSM Biologics operates two manufacturing facilities, one in Groningen, the Netherlands (ca. 550 liters fermentor capacity and 2,400 m2) and one in Montreal, Quebec, Canada (ca. 6,000 liters fermentor capacity and presently 6,500 m2).

For more information, visit http://www.dsmbiologics.com.

DSM Biologics is represented by Asahi Glass Co., Ltd. in Japan.

About Mitsubishi

Mitsubishi Pharma Corporation is a global research-driven pharmaceutical company targeting the therapeutic areas of cardiovascular and metabolic diseases, psychiatric and central nervous system diseases, immunological and respiratory diseases, and cancer and hepatic disease. The company was founded by the merger between former Welfide Corporation and Mitsubishi-Tokyo Pharmaceuticals, Inc., on October 1, 2001. Mitsubishi Pharma Corporation has established a strong drug discovery infrastructure to engage in the development of innovative new drugs.

For more information, visit http://www.m-pharma.co.jp.