COC-ARV drug interactions.
COC-ARV Drug Interactions
Non-nucleoside reverse Effect of ARV Use on Effect of COC Use on
transcriptase COC Blood Levels ARV Blood Levels
Delavirdine Possibly increases No data
Efavirenz * Increases No change
Nevirapine Decreases No change
Amprenavir Increases Decreases
Atazanavir Increases No data
Indinavir Increases No data
Lopinavir + ritonavir Decreases No data
Nelfinavir Decreases No data
Ritonavir Decreases No data
Saquinavir No change No change
Zidovudine, stavudine, None expected None expected
Tenofovir No change No change
Enfurvitide None expected None expected
* Should not be given to women of childbearing potential unless
effective contraception can be ensured.
Note: The ARV combinations recommended by the World Health Organization
consist of two NsRTIs and either one NNRTI or one protease inhibitor.
Each of the pharmacokinetic studies that produced these data assessed
interactions between contraceptive hormones and a single ARV drug,
rather than the two- or three-drug combinations taken by the vast
majority of HIV-infected patients. In most cases, only one study has
been conducted for each drug, and most of the studies have not been
published in a peer-reviewed journal.
Sources: World Health Organization (WHO). Improving Access to Quality
Care in Family Planning: Medical Eligibility Criteria for Contraceptive
Use. Third Edition. Geneva, Switzerland: WHO, 2004. Available:
Up Antiretroviral Therapy in Resource-Limited Settings: Treatment
Guidelines for a Public Health Approach. Geneva, Switzerland: WHO,
2004; Center for HIV Information, University of California San
Francisco, School of Medicine. Interactions between ethinyl estradiol/
norethindrone acetate (Ortho-Novum, others) and antiretrovirals.
Database of Antiretroviral Drug Interactions,August 2005. Available: